Protein Alignment Klp3A and Kif2a

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001361656.1
• Gene: Kif2a / 16563
• MGIID: 108390
• Length: 743
• Species: Mus musculus
• Alignment Length: 533
• Identity: 152/533 - (28%)
• Similarity: 244/533 - (45%)
• Gaps: 93/533 - (17%)

  Fly     5 DPSCVAVALRVRPLVQSELD-RGCRIAVERSAD----GAPQVTVN-----RNESYTYNYVFDIDD 59
            |...:.|.:|.|||.:.|.. :...:....|.|    ..|:..|:     .|:::.::|.||...
Mouse   219 DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSA 283

  Fly    60 SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDD-HVGVIPRAVHDIFTA 123
            ..:.::....:..|:.:......|..||||||||||:|||..|:|...| ..|:...|..|:|..
Mouse   284 PNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLM 348

  Fly   124 IAEMQ-SEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVT 187
            :.:.. .:....|..:|.|:|..:.:||.:.||:.:.   :.:.|.::.:.||.|..|...:.|.
Mouse   349 LKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRV---LEDGKQQVQVVGLQEREVKCVEDVL 410

  Fly   188 DHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVAT-KLDGKQSVTTSRFNLVDLAGSERCSKTLA 251
            ..:..|::.|....|:.|..||||||:|.:.|... ||.||       |:|:||||:||.:.| :
Mouse   411 KLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGK-------FSLIDLAGNERGADT-S 467

  Fly   252 SGDRFK--EGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDS-LGGNSITLMIACVS 313
            |.||..  ||..|||.||||...|.|||..:.  :.|:|.||||::|:|| :|.||.|.|||.:|
Mouse   468 SADRQTRLEGAEINKSLLALKECIRALGRNKP--HTPFRASKLTQVLRDSFIGENSRTCMIATIS 530

  Fly   314 PADYNVAETLSTLRYADRALQI-----------------KNKPVVNLDPHAAEVNMLKDVIQKLR 361
            |...:...||:|||||:|..:.                 ...|..:.|..:..:..:|:    |.
Mouse   531 PGMASCENTLNTLRYANRVKEFGISPSDIPFSQGGGSRPDLSPSYDYDDFSPSITRVKE----LT 591

  Fly   362 VELLSGGKM-------SSSLISAVGAAGLGAIP--------CEES-------LAGSMANAAEIQR 404
            |...:.|.:       .|.:.......|:|:.|        ||::       |.......:::..
Mouse   592 VNPAAAGDVHPIMHHPPSQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVE 656

  Fly   405 LKEQVRTLQDRNRKLQQEL-----HQSLLDLTEK----------EMRAHIAEQAHD---KLRSHV 451
            ::|||  ::|.....|:.:     .::||::||:          ::.| |.||..|   :||..|
Mouse   657 MEEQV--VEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEA-ILEQKIDILTELRDKV 718

  Fly   452 SELKNKLDQREQA 464
            ...:..|.:.|||
Mouse   719 KSFRAALQEEEQA 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	117/361 (32%)
		Smc	<453..>985	CDD:440809	4/12 (33%)
		Metallothio	<1071..1115	CDD:395080
Kif2a	NP_001361656.1	KISc_KIF2_like	222..550	CDD:276818	117/340 (34%)