Protein Alignment Klp3A and Kif1a

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_006529218.1
• Gene: Kif1a / 16560
• MGIID: 108391
• Length: 1800
• Species: Mus musculus
• Alignment Length: 1238
• Identity: 303/1238 - (24%)
• Similarity: 494/1238 - (39%)
• Gaps: 355/1238 - (28%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNE------SYTYNYVF-------DID-D 59
            |.||:||||....|:.|..:..::.|  |:....||..:      |::::|.:       ||: .
Mouse     6 VKVAVRVRPFNSREMSRDSKCIIQMS--GSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYA 68

  Fly    60 SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAI 124
            |||.::....:..::....||||.|.||||||:||:|||   ......|..|:||:...|:|:.|
Mouse    69 SQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTM---MGKQEKDQQGIIPQLCEDLFSRI 130

  Fly   125 AEMQSE-FRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTELVVTSAQQ 185
            .:..:: ..::|..|::|:|.|:..||.:.|  :|..:.:||  :.::.|   .|::|.|||...
Mouse   131 NDTTNDNMSYSVEVSYMEIYCERVRDLLNPK--NKGNLRVRE--HPLLGPYVEDLSKLAVTSYND 191

  Fly   186 VTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTT---SRFNLVDLAGSERCS 247
            :.|.:..|:..|.||||.||||||||||:|.:.....:.|.:.::||   |:.:|||||||||..
Mouse   192 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERAD 256

  Fly   248 KTLASGDRFKEGVNINKGLLALGNVINALG---SG-------QAAGYIPYRQSKLTRLLQDSLGG 302
            .|.|.|.|.|||.||||.|..||.||:||.   ||       :...:||||.|.||.||:::|||
Mouse   257 STGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGG 321

  Fly   303 NSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELL-- 365
            ||.|.|:|.:||||.|..||||||||||||.||:...::|.||:...:..|||.:.:|| :||
Mouse   322 NSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLR-DLLYA 385

  Fly   366 -------------SGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAE-----------IQRLK 406
                         .|.|::::|:....::.|.|:   .|.|.|:::..|           |:|||
Mouse   386 QGLGDITDTNTVPGGPKLTNALVGMSPSSSLSAL---SSRAASVSSLHERILFAPGSEEAIERLK 447

  Fly   407 EQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQA-------------HDKLRSHVSELKNKL 458
            |..:.:.:.|...:::|.::  :....|..|.:||..             ..|...|:
Mouse   448 ETEKIIAELNETWEEKLRRT--EAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHL------- 503

  Fly   459 DQREQAQFGNENTNGDNEMRDFSLL-----VNRVHVELQRTQEELESQGHESRQ-----RLSSRS 513
                      .|.|.|..|.:..|.     |.||..|....::::...||..::     |..||.
Mouse   504 ----------VNLNEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRG 558

  Fly   514 HTEGGES--------GGD-----------------------EVHEMLHSHSEEYTNKQ------- 540
               |||:        |.|                       :.|....:|.|:...::
Mouse   559 ---GGEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAE 620

  Fly   541 -----MNFAGELRNI--NRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLM 598
                 :::|...|.:  .:.:|:|||:.:|:                              ::|.
Mouse   621 TPAEPVDWAFAQRELLEKQGIDMKQEMEQRL------------------------------QELE 655

  Fly   599 DQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIR-----DKEREKIQNLSTE 658
            ||.|            .||.:...||||:..|...||......:..|     ::|.|:.::   |
Mouse   656 DQYR------------REREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPED---E 705

  Fly   659 IR-TMKESKVKLIRAMRGESEKFRQWK----------------MVREKELTQLKSKDRKMQSEIV 706
            :: |.:|.::.|        ..||:||                .::|.....::.|.:.....::
Mouse   706 VQWTERECELAL--------WAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVL 762

  Fly   707 RQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSW- 770
            ...||:|...                 .|.|..:|:...:...:.....:.......|..|..|
Mouse   763 LTDTLYSPLP-----------------PDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWT 810

  Fly   771 ---VDRELEIILSLID-AEHSLEQLMED----------------------RAVIN--NHYHLLQ- 806
               :.:.|:::..:.| |......::||                      .:||:  |.|.||.
Mouse   811 LEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGSSVISGCNSYPLLNT 875

  Fly   807 ------------------QEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRI 853
                              ...|::|||  ||:......|||.|....:..||:..|.|.
Mouse   876 CMSERMAALTPSPTFSSPDSDTTEPAE--EQSVGEEEEEEEEEEEEEEEEDLEDDVFPE------ 932

  Fly   854 RSLAEG----------VQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQ 908
            .:|.:|          ...:|.:......||..:....|:  :.::|:......||..:......
Mouse   933 HTLCDGQDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRV--AIVSEKGEVKGFLRVAVQAISAD 995

  Fly   909 EDAASKRLRLLQS---------QHEEQ-------MLAQQRAYEEKVSVLIRTANQRWAEARSPAE 957
            |:|......:.||         ||.|:       ::...|:...:..:.|.....:.|:| .|:.
Mouse   996 EEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADA-GPSA 1059

  Fly   958 DQQRNQIL-----EELLSSRE------ALQQELDKLRAKNK-------SKSKAVKSEPQDLDDSF 1004
            |:..|...     |.|:.|.|      .|...||.||..:.       .::.::.:|..|:...|
Mouse  1060 DEVNNNTCSAVPPEGLMDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQF 1124

  Fly  1005 QIV 1007
            ..:
Mouse  1125 NFI 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	146/357 (41%)
		Smc	<453..>985	CDD:440809	121/693 (17%)
		Metallothio	<1071..1115	CDD:395080
Kif1a	XP_006529218.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	147/363 (40%)
		Kinesin_assoc	358..524	CDD:465047	37/188 (20%)
		FHA_KIF1A	500..614	CDD:438778	23/133 (17%)
		ERM_helical	633..>686	CDD:466641	19/94 (20%)
		KIF1B	814..861	CDD:463574	5/46 (11%)
		DUF3694	1250..1406	CDD:463599
		PH_KIFIA_KIFIB	1681..1783	CDD:269939