Protein Alignment Klp3A and Kif17

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_034753.1
• Gene: Kif17 / 16559
• MGIID: 1098229
• Length: 1038
• Species: Mus musculus
• Alignment Length: 1284
• Identity: 305/1284 - (23%)
• Similarity: 506/1284 - (39%)
• Gaps: 331/1284 - (25%)

  Fly     1 MSSEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGA--------PQVTVNRNESYTYNYVFDI 57
            |:||.   |.|.:|.||:.:.|.:..|:..|  :.|.|        |.......:.:|::..:.|
Mouse     1 MASES---VKVVVRCRPMNKRERELSCQSVV--TVDSARGQCFIQNPGAADEPPKQFTFDGAYYI 60

  Fly    58 DDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDD--HVGVIPRAVHDI 120
            :...:.::.......|:.:..|||.||.|||||||||::||    .|:.|.  ..|:||||...:
Mouse    61 EHFTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTM----QGLPDPPCQRGIIPRAFEHV 121

  Fly   121 FTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR-IIMPGLTELVVTSAQ 184
            |.:: :.....:|.|..|::|:|.|..:||..:.|:.:  ::::|...: :.:.||:...|.:..
Mouse   122 FESV-QCAENTKFLVRASYLEIYNEDVHDLLGADTKQR--LELKEHPEKGVYVKGLSMHTVHNVA 183

  Fly   185 QVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLD--GKQSVTTSRFNLVDLAGSERCS 247
            |....:..|...|||..|.||:.|||||:|||:.:....:|  ||..:...:.||||||||||.|
Mouse   184 QCERVMETGWKNRAVGYTLMNKDSSRSHSIFTINIEIYAVDERGKDHLRAGKLNLVDLAGSERQS 248

  Fly   248 KTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACV 312
            ||.|:|:|.||...||..|.||||||:||..|:.. :||||.||||||||||||||:.|||:||:
Mouse   249 KTGATGERLKEATKINLSLSALGNVISALVDGRCK-HIPYRDSKLTRLLQDSLGGNTKTLMVACL 312

  Fly   313 SPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVEL---LSGGKMSSSL 374
            ||||.|..|||||||||:||..|||||.:|.||..|.:...::.|::|:..|   :..|.:|:.|
Mouse   313 SPADNNYDETLSTLRYANRAKNIKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGNLSALL 377

  Fly   375 ISAVGAAGLGAIPCEESLAG----SMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEM 435
            .:....   |.:..||.|..    .....||.|.::|:   .::|..:|:.:..      .|:|.
Mouse   378 STQTPP---GPVQSEEKLLSPTTVQQDTEAEKQLIREE---YEERLARLKADYE------AEQES 430

  Fly   436 RAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELES 500
            |.        :|:..::.::|..|                             |:|...||.|..
Mouse   431 RV--------RLQEDITAMRNSYD-----------------------------VKLSTLQENLRK 458

  Fly   501 QGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIM 565
            :           ..||.                                     .||.|:
Mouse   459 E-----------KETEA-------------------------------------ILKAEV----- 470

  Fly   566 RNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISD 630
                            ||          :.::|.:.......:.|..|..|...:..:|......
Mouse   471 ----------------LC----------KTEVMSRAELASGPEYSPPLQYETAVKPTILSMPDMP 509

  Fly   631 LRRKLITQANLLKIR----DKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKEL 691
            ...|:......|...    :..|.:....|.|..|:::|...  .|..| .|:|...:......|
Mouse   510 PSGKVTKSQAPLAFEEPHGETSRSEFSFESNECSTLEDSATS--EAFPG-PEEFSNMEFSMAAAL 571

  Fly   692 TQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGS 756
            |         :|..:.::.|..::......:.|..:..|:...:.|...||.|   ..:.:....
Mouse   572 T---------ESRYLPEEYLGGQEAAASPLEAERYVQENEPSLEPLRILASLQ---DPFAEVEAK 624

  Fly   757 AAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQAR 821
            .|..|:..|.:||     .:.::..|..:.|...|:|             ...|...|:.|....
Mouse   625 LARLSSTVAMSDS-----SQTVVPQIPKQPSSADLLE-------------PSDTKSEADVAVADN 671

  Fly   822 ILASLEEELEMRNAQ--ISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQ 884
            ::...|.::.:|.|:  :|:.:..|. .:.::::..:|:      .|.....|.|..:|..||
Mouse   672 VVLGTEPDVNLRVAEEVVSEAETGVW-MESEAQVAHVAQ------VSEEAQPQPLLAMVSVRR-- 727

  Fly   885 ASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRW 949
             .|:..:...|.|...|.:|.||    ...||:||    |:|::..::|..:.    :|..::|
Mouse   728 -ESVGVEVAVLTEEELQPVDQQQ----VLARLQLL----EQQVVGGEQAKNKD----LREKHKR- 778

  Fly   950 AEARSPAEDQQRNQILEELLSSRE------------ALQQEL---DKLRAKNKSKSKAVKSEPQD 999
               |....|:::.|::..|.:|.|            ::|:|:   .||..|.:.|.:|.:.|.:|
Mouse   779 ---RKRYADERKKQLVAALQNSDEDGGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKD 840

  Fly  1000 LDDSFQI--VDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSR------NVISPPEKQDANVTSLG 1056
            |...||:  :|...|:                  :|.:.||.      ..:.|..::|.|.::|.
Mouse   841 LQSEFQLEKIDYLATI------------------RRQERDSMLFQQLLEQVQPLIRRDCNYSNLE 887

  Fly  1057 NSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACSETCVCKSNCRNPLNLKDHASQC 1121
            ....:|    |..||....|                               ..:|:.||......
Mouse   888 KIRRES----SWDEDNGFWK-------------------------------IPDPIILKTSLPVV 917

  Fly  1122 GDGDGQKDETEDADKSDDDGDDEPQTSKENAVKFVTPEAPGKVVAS---------------PKQT 1171
            ..|    .:.:.|.|:......||...:|:..|.:...:..:.:||               |.::
Mouse   918 PTG----TQNKPARKTSAVDSGEPHMQEEDRYKLMLSRSDSENIASNYFRSKRASQILSTDPMKS 978

  Fly  1172 L---QEPKAAATPLMNSNVVEDINGPKL-------AKMSGLAFDTPKRK 1210
            |   ..|....:.|.|::.:.....|::       .:...:.|...|||
Mouse   979 LTYHNSPPGLNSSLSNNSALPPTQTPEMPQPRPFRLESLDIPFSKAKRK 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	139/341 (41%)
		Smc	<453..>985	CDD:440809	90/552 (16%)
		Metallothio	<1071..1115	CDD:395080	3/43 (7%)
Kif17	NP_034753.1	Motor_domain	4..335	CDD:473979	140/343 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..401		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..559		10/58 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..657		6/38 (16%)
		COG4913	655..>874	CDD:443941	55/275 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	916..940		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	976..1038		9/52 (17%)