Protein Alignment Klp3A and LOC1278752

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_061505800.1
• Gene: LOC1278752 / 1278752
• VectorBaseID: AGAMI1_011731
• Length: 1432
• Species: Anopheles gambiae
• Alignment Length: 1377
• Identity: 342/1377 - (24%)
• Similarity: 562/1377 - (40%)
• Gaps: 369/1377 - (26%)

  Fly    11 VALRVRPLVQSELDRGCRIAVERS------------------ADGAPQVTVNRNESYTYNYVF-D 56
            ||:||||..|.|.:.|.::.|:..                  .|.|.:..::....:|:::.: .
Mosquito     6 VAVRVRPFNQREHELGAKLIVQMDGKKTRLLKPKLGTGNGVRGDLASRAALDPFNDFTFDHSYWS 70

  Fly    57 IDD------SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIP 114
            :|:      .|:.:|:......|.....|||..:.||||||||||:| |||      .:..|:||
Mosquito    71 VDERDPHFTHQETVFDDLGTEIVDCAFQGYNACVFAYGQTGSGKTFTMMGT------PEAQGLIP 129

  Fly   115 RAVHDIFTAIAEMQSE-FRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GL 175
            |....:|..:...|.| ..:...||::|:|.|:..||....:   |...:|..::|.:.|   .|
Mosquito   130 RICRSLFARMKLGQEEGTGYKTQCSYLEIYNERVKDLLGPSS---AGHGLRVREHRTLGPYVESL 191

  Fly   176 TELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLV-ATKLDGKQSVTTSRFNLVD 239
            ::..|:...::.:.:|:|:..|..|:|.||:||||||||||:|.| |..|:...|.|.|:.:|||
Mosquito   192 SQHPVSDYSEIQNCMIQGNIQRTTASTNMNDTSSRSHAIFTITFVQARYLNDLPSETVSKIHLVD 256

  Fly   240 LAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG------SGQAAGYIPYRQSKLTRLLQD 298
            ||||||.:.|.|:|.|.|||.:|||.|:.||:||:||.      :.:...|||||.|.||.||:|
Mosquito   257 LAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTNPTNNKRVLYIPYRDSILTWLLKD 321

  Fly   299 SLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVE 363
            ||||||.|:|||.:||||.|.:|||||||||:||..|.|||.:|.||:...:..|:|.|.||::.
Mosquito   322 SLGGNSKTIMIAAISPADVNYSETLSTLRYANRAKNIINKPTINEDPNVKLIRELRDEIYKLKLM 386

  Fly   364 LLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLL 428
            |.|..               ||                  .|:.|::.|:|.::|   |..:.:|
Mosquito   387 LSSDS---------------GA------------------ELEPQLKVLEDLHKK---EAQEKVL 415

  Fly   429 --DLTEK--EMRAHIAEQAHDKLR-SHV-----SELKNKLDQREQAQFG--------NENTNGDN 475
              :.|||  |.::.:.||....|| |.|     ||:.:.:...:....|        .|.|.|.:
Mosquito   416 TEEWTEKWREAQSILREQRSLGLRKSGVGVVLDSEVPHLIGIHDDISTGVTLYSLKEGETTIGTD 480

  Fly   476 EM---RDFS------------------------------------------------LLVNRVHV 489
            |.   :|.|                                                ||:.|.::
Mosquito   481 EAPYPQDISLNGIGIAPEHCRIVLSNGNATIYPNPNATCLLNASIIEVPTAISQGDILLLGRTNM 545

  Fly   490 -------ELQRTQEELESQGHESRQRLS-------SR--------SHTEGGESGGD--------- 523
                   |..:.::|...|...||..||       ||        |..:||.||..
Mosquito   546 FRYNNPAEAAKMRQESSHQQRASRLDLSRLSLIAASRENLCASFMSDDDGGVSGSSLSLFGGGGG 610

  Fly   524 ------------EVHEMLHSHSE-EYTNKQMNFAGELRNINRQLDLKQ-ELHERIMRNFSRLDSD 574
                        ...:...|..: |..::.......:.|..|||:|:: .:||:...
Mosquito   611 GGGGMASPQGAFRFRQYTPSREDAELQDEHRKILQTIENALRQLNLERTRMHEQFKH-------- 667

  Fly   575 DEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAK----LAEERRKRLQ--LLEQEISDLRR 633
                |:|||.::::.||:.:||.:..| :.:..::.|:    |.|:..::.|  :|.:::|.|:.
Mosquito   668 ----KIRLCTEELERLESTKRDRLTVL-DCRIGELMARKEMVLWEKSNEKTQVDILVRQLSALQT 727

  Fly   634 KLITQANLLKIRD------KEREKIQN------LSTEI-----RTMKESKVKL------------ 669
            :|.|     |.||      ||.:::|:      .|:|:     :|...|::.|
Mosquito   728 QLDT-----KKRDFYEYVAKELQELQDCGRLDEASSELIRNAPQTEDYSEILLQISRSLDNYSQQ 787

  Fly   670 -----IRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEE--AL 727
                 :|..|.|..|:......:|::|.|...|...:..:|:.   |..:.|::|:::.::  .|
Mosquito   788 YIKEFVRRNRDEINKYEAELSEKEQQLAQSTQKIADLDQKIME---LEQQNRELLQQRTQQELEL 849

  Fly   728 AANKRLKDALE-RQASAQAQRHKYKDNGGSAAGSSNA----NAKTDSWVDRELEIILSL-IDAEH 786
            ...|:|...|. ...:...:.....:..|...|::.|    ...|....:.:...:.:| ..|.:
Mosquito   850 IQQKKLGMTLNLTHTNGADEGEGTGEQAGLLLGTNRAGTLETCDTFHTANSDCSFVSALNTPALN 914

  Fly   787 SLEQLM------EDRAVINNHYHLLQQEKTSDP--AEAAEQARILASLEEELEMRNAQISDLQQK 843
            ||.||:      ||..          :..|.|.  .||.....:|..     .|.::.:|....:
Mosquito   915 SLNQLIPTPSSTEDGT----------ESDTGDRDYEEATSNGGLLHG-----GMSDSGVSFETNR 964

  Fly   844 VCPTDLDSRIRSLA-----EGV---QSLGESRTVSKQLLKTLVQQRRLQASSLNEQR-------- 892
            .  ||..:.:.:.|     ||.   ||.|.:...:|.|.::......|..||....:
Mosquito   965 A--TDTAAALHTEADENESEGSVDRQSSGAASGTAKLLFQSDDHCLLLATSSTPNPKYGGKKLPT 1027

  Fly   893 TTLDELRAQ---LLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARS 954
            ||...:...   ||.:.||:...|.|:|...|..||:                ||.....:...:
Mosquito  1028 TTTTVIVTDGGGLLKSNQQQPQQSPRMRHKSSDSEEE----------------RTTVTTMSSIGT 1076

  Fly   955 PAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVS 1019
            |..::.:..:.....|:             .|.|||.::::|      .|.|..|...:.:|.||
Mosquito  1077 PGSNRLKLSVPNRNRSN-------------SNNSKSSSMRTE------IFDIRHGIHPLRVSSVS 1122

  Fly  1020 DDPDWVPSTSKSKRIQSDS------RNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGC 1078
            ...|  .|..:.:..:.|:      |..:...|::.:..:|:.||||     ||:|.:...|:..
Mosquito  1123 SGTD--GSHEEEEYEEEDAHGRRRHRQEVDDEEERRSRGSSIDNSSI-----TSSTANLILCEMN 1180

  Fly  1079 KCRTKCTTKRCGCL-----SGNNACSETCV------CKSNCRNPLNLKDHASQC-GDGDGQKDET 1131
            ..|....:|:...:     :|:....:..:      .|...:..:.::|....| .||:.|.|..
Mosquito  1181 HLRESIASKKAEIMKILETNGDKKLLDGKIGELQDLQKRIVQLEIKIQDVEKSCLSDGELQLDSM 1245

  Fly  1132 EDADKSDDDGDD 1143
            .|..:|..|.||
Mosquito  1246 RDIPESFTDSDD 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	141/361 (39%)
		Smc	<453..>985	CDD:440809	127/710 (18%)
		Metallothio	<1071..1115	CDD:395080	5/54 (9%)
LOC1278752	XP_061505800.1	None