Protein Alignment Klp3A and Klp31E

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_061516566.1
• Gene: Klp31E / 1278143
• VectorBaseID: AGAMI1_013230
• Length: 1675
• Species: Anopheles gambiae
• Alignment Length: 1391
• Identity: 372/1391 - (26%)
• Similarity: 595/1391 - (42%)
• Gaps: 328/1391 - (23%)

  Fly     1 MSSED-PSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDL 64
            |..|| .|.|.||:|:||.:..||...||:..: ...|.|||.:..::::|::||||:..:|..:
Mosquito     1 MPDEDKESSVRVAVRIRPQIPRELIDMCRVCTQ-VTPGEPQVLLGSDKAFTFDYVFDMSTTQVSV 64

  Fly    65 FETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDD-HVGVIPRAVHDIFTAIAEMQ 128
            :..|::..|...|.|||.|:||||||||||||||||.|...|.: ..|:|||||..:|..||::|
Mosquito    65 YNNCIEKLVDGALQGYNATVLAYGQTGSGKTYTMGTGFERALPEAQEGIIPRAVRHLFEGIAQLQ 129

  Fly   129 SE-----------FRFAVTCSFVELYQEQFYDLFSSKTRDKATVDI-REVKNRIIMPGLTELVVT 181
            ..           ..|:|...|:|||.|:..||.....:......| .:....|.:.|.|...:.
Mosquito   130 QNPYDEDGTYLGTVTFSVAAQFMELYNEEVIDLLDPYNKGARVFKIFEDATGGISVAGATIKPLA 194

  Fly   182 SAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKL---------DGKQSVTTSRFNL 237
            ..|:..:.|.:|:..|..|:|.|||.||||||:||:.:...::         :|.....||:|:.
Mosquito   195 GPQEALNCLQQGALARTTASTQMNEQSSRSHALFTILIRRQRVMTAEQCGNAEGDTETLTSKFHF 259

  Fly   238 VDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIPYRQSKLTRLLQDSLG 301
            ||||||||..:|.|:|:|.:||::||.|||||||||:||| ..:...::|||.||||||||||||
Mosquito   260 VDLAGSERLKRTGATGERAREGISINCGLLALGNVISALGDKTKKVSHVPYRDSKLTRLLQDSLG 324

  Fly   302 GNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELL- 365
            |||.|:|||||||:|.:..|||:||:||:||..||||..:|.|..:..:::|:..|..|::|:|
Mosquito   325 GNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVQINQDQSSRTISLLRREIANLQLEILE 389

  Fly   366 -SGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLK---EQVRTLQDRNRKLQQELHQS 426
             ..||.|   |.|.|...:..:..|..:. |..|....||:|   |.:..|.::|..||.:  |:
Mosquito   390 YKQGKRS---IDADGNIAISDVSLENEML-SQDNKRLQQRVKAMQETINALTEKNAALQAQ--QT 448

  Fly   427 LLDLTEKEMRAHIAEQAHD------------------------------KLRSHVSELKNKLDQR 461
            :..|       |.|..|.|                              ...|.:.:||.||.:.
Mosquito   449 IASL-------HKASAAGDGGADATSTNNGSSPVGTAGGNDSAMQELIVGYISEIEKLKAKLIES 506

  Fly   462 EQ--AQFGNENTN------------GDNEMRDFSLLVNRVHVELQRTQEELESQG-----HESR- 506
            ||  .||....::            .||.    ..::|.:..|:::.:|.|.|:.     |||.
Mosquito   507 EQMFQQFKKAKSSQSKLGIKTYPFIEDNP----ETMINMLKHEMEKERETLMSRSLPGLEHESSS 567

  Fly   507 --QRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFS 569
              |...|.|.||     .|:..|:|.:              |:.::|..::||..|.|::..:..
Mosquito   568 MDQNSDSDSDTE-----SDDKAEVLRA--------------EMSDVNSDIELKVRLIEQLEESQQ 613

  Fly   570 RLD--SDDEDVKLRLCNQKIDDLEAERRDLMDQL-------RNIKSKDISAKLAEERRKRLQLLE 625
            ||.  ....:.:..|..:||.:.|.||.:::..:       .|.|.::...:.|.:|.|  :..|
Mosquito   614 RLQIMRQQYEKQFNLMKEKISNTERERDEVLATIGNGGTGAMNNKGQNSGNETAIKRVK--EDYE 676

  Fly   626 QEISDLRRKLITQANLLKIRDKER-----------EKIQNLSTEIRTMKESKVKLIRAMRGESEK 679
            :::::|||:|    |..:..:||.           .||:.|..|:..:|:.|.:|::.::.||.:
Mosquito   677 RKLNELRRQL----NHFQATNKEHLRLQRNMQAQDAKIKTLRGELAELKQVKTRLMKKIQEESNR 737

  Fly   680 FRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQ 744
            .::.:..:.:|:.||:.:.||.::.|...|...:.:.||||||.||.....|..:..:..:|:.:
Mosquito   738 HKEMESRKTREIAQLRKETRKHKNMIKSLQAQGAAKDQVLKRKTEEVFNLRKSQRGIMSLKAAGR 802

  Fly   745 AQRHKYKDNGGSAAGSSNANAK--TDSWVDRELEII------LSLIDAEHSLEQLMEDRAVINNH 801
            .|       |.::.||.....|  ...|.:.:..|:      .::::.|..||::|::|.|::..
Mosquito   803 VQ-------GNTSIGSMLQGTKRFKSRWEELQRSIMRAARTRQAVLELEMELERVMQERDVLSRD 860

  Fly   802 YHLLQQEKTSDPAEA------AEQARILASLE------EELEMRNAQISD--------------- 839
            ...|:|.: .|.||:      :|:..|:|::.      .||:....||.|
Mosquito   861 LTNLRQRR-KDNAESTLQDLVSEEDTIIANMNYLHDTITELQKSIIQIEDGKDLNSEHLMLQTIM 924

  Fly   840 -----------LQQKVCPTDL---------DSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQ 884
                       :.|:||...:         .|::|.....:..|....:|.:|||:.::  .|..
Mosquito   925 ENIGTVEEAKFMLQRVCTVTIGHVCEAGVAQSKLRERDALLTELQRDTSVQEQLLQYIL--TRAP 987

  Fly   885 ASSLNEQRTTLDELRAQLLDAQQQED-AASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQR 948
            |:|.::         |....||.... |...:..||::...:...:||......|.
Mosquito   988 AASASD---------ASFSSAQSANSYATQSQANLLENGEPQPSSSQQYRLPHVVD--------- 1034

  Fly   949 WAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETV 1013
             :..|||:.... |..|:.:::.|             |.||.:.
Mosquito  1035 -STTRSPSPSSS-NTNLDSIVTYR-------------NSSKQRR--------------------- 1063

  Fly  1014 VLSDVSDDPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGC 1078
                   :|..|||.:..:.:...|.:....|....|     |...|...|...:..:|.
Mosquito  1064 -------NPSVVPSVATIQDLLYGSSSSYVGPAGDGA-----GGVGIPDRNLNHSAGNGG----- 1111

  Fly  1079 KCRTKCTTKRCGCLSGNNACSETCVCKSNCRNPLNLKDHASQCGDGDGQK--DETEDADKSDD-- 1139
                  |....|..||.:...:..:|       :.|:|.|    |.|..|  ...:|..:..|
Mosquito  1112 ------TGASNGASSGGSKLEKVGIC-------IYLEDSA----DDDDTKHPPSLQDRHERSDVM 1159

  Fly  1140 -------DGDDE--------------PQTSKENAVKFV----TPEAPGKVVA-SPKQTLQEPKAA 1178
                   ||..:              |..:...|..||    .|.|||.:.. .|.|.|....:.
Mosquito  1160 TRSYTILDGAMDAVAAANAGLPIAPPPPVAPVPARTFVPLSRVPSAPGSLKGLQPHQGLSRQNST 1224

  Fly  1179 ATPLMNSNVVEDINGPKLAKMSGLAF 1204
            |:||:.....|....|...::|...|
Mosquito  1225 ASPLLARKSFEASGAPSSPRISRRTF 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	154/351 (44%)
		Smc	<453..>985	CDD:440809	133/629 (21%)
		Metallothio	<1071..1115	CDD:395080	6/43 (14%)
Klp31E	XP_061516566.1	None