Protein Alignment Klp3A and Klp67A

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_308943.5
• Gene: Klp67A / 1270262
• VectorBaseID: AGAMI1_014522
• Length: 938
• Species: Anopheles gambiae
• Alignment Length: 1045
• Identity: 256/1045 - (24%)
• Similarity: 428/1045 - (40%)
• Gaps: 248/1045 - (23%)

  Fly     3 SEDPSCVAVALRVRPLVQSELD---RGCRIAVERSA--------------DGAP----QVT--VN 44
            |.|...:.||:||||..:.||:   |.....:::|.              .|..    .:|  |.
Mosquito     2 STDSRKIRVAVRVRPFNERELEGNPRNIIKVLDKSTLMFDPDEDEDEFFFHGVKLTHRDITKRVK 66

  Fly    45 RNESYTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH 109
            :..:..|:.|||...:..|:||.|::..|:.::||||.::..||.||:|||:||       |.:.
Mosquito    67 KKLTMEYDDVFDNTATNNDIFEVCMKPLVQSVMNGYNCSVFVYGATGAGKTHTM-------LGNE 124

  Fly   110 V--GVIPRAVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIM 172
            .  |:....|.::|..|..:....:|.:..|::|:|.|...:|.:.    ...:.:||..:.::|
Mosquito   125 TCPGITFLTVKELFHQIESLSEVRKFDIGISYLEVYNELVMNLLTK----SGPLKLREDSHGVVM 185

  Fly   173 PGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFT--LTLVATKLDGKQSVTTSRF 235
            .||....:.:|.::.:.|..|:..|....|..|..||||||||.  :.:|..|...|::|   :.
Mosquito   186 SGLVLKQIHNATELLELLALGNRNRTQHPTDANAESSRSHAIFQVHIRMVEKKTGQKRAV---KL 247

  Fly   236 NLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSL 300
            :::|||||||.:.|...|.|||||.||||.||||||.||.|..|  ..:||||.|.|||:|:|||
Mosquito   248 SMIDLAGSERAASTKGVGIRFKEGANINKSLLALGNCINKLADG--LKHIPYRDSNLTRILKDSL 310

  Fly   301 GGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELL 365
            |||..|:|||.:||:.....:|.:||:||.||.:|:.....|:.|.    |:.|:.:.|
Mosquito   311 GGNCQTVMIANISPSSLTYDDTYNTLKYASRAKKIRTTVRQNIVPS----NVPKEFLVK------ 365

  Fly   366 SGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQE-------- 422
               |::.                         .|.|::||:.:|..|:::.||.:||
Mosquito   366 ---KVNE-------------------------QAEELERLRAKVADLEEQLRKKEQEAAAAAAPG 402

  Fly   423 ----LHQSLL-------DLTEKEMR---AH-IAEQAHDKLRSHVSELKNKLDQREQAQ------- 465
                |:.:||       |.....||   .| ||.::.:||      |..::..:|||:
Mosquito   403 PSLALNATLLNTWVSRIDSCYASMRQALQHLIALKSKEKL------LNMRVKLKEQAETIARIVT 461

  Fly   466 FGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESRQRLSSRSH-------------TEG 517
            ....:.|.|....:.|  |:|...::...|.:........||.|.||:.             .:|
Mosquito   462 LDGSHLNEDIAKMEAS--VDRCGKQVANQQADKTRWQERFRQSLRSRNALRKEIAQSELATVLKG 524

  Fly   518 GESGGDEVHEMLHS--HSEEYTNKQMNFAGELRNINRQLDLKQELHER---IMRNFSRLDSDDED 577
            ..:|.|...|.|.:  :.|........:|.|.:..:..:.|..::.::   ::|:..|||:...|
Mosquito   525 ILTGKDAEIEALQATLYKEHVLQMSFTYAQENKLWHNIMVLSGDIIQQNYLLLRSMDRLDNVTYD 589

  Fly   578 VKLRL--CNQK------IDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLL---EQEISDL 631
            ...||  .||:      .|| :.:::|..|...:..|.|..|.|::.....:...   |.|....
Mosquito   590 KLKRLVKLNQRQRGVTFFDD-DGQQQDRNDIDLSSNSLDDIANLSDCSEDAVDFPPDGEDEDGST 653

  Fly   632 RRKLITQA-----NLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREK-- 689
            .|.::..|     ...|:.|....:.:..|.:..:..|...       .:...|::.|||...
Mosquito   654 MRSVVGGAAGGAMKRSKLNDGSESEPETCSLQGDSANEDTA-------SDRNIFKKPKMVSRTMS 711

  Fly   690 -ELTQL-----------KSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQAS 742
             :.|.|           ..:....|:::..:.|..:....|..|.....|..::.:.|:|.::..
Mosquito   712 FKTTSLAGGGILSRPPISRRTPTKQAKVTGKTTATTTTATVSHRLKVPRLVVSQAMMDSLSKKKV 776

  Fly   743 AQ------AQRHKYKDNGGSAAGSSNANAKTD--SWVDRELEIILSLIDAEHSLEQLMEDRAVIN 799
            .|      |.::|...:..|:...|.||:..|  |..|.|.|.:.|.:..|.::
Mosquito   777 PQSPSGDIADKNKLNVSDDSSGIGSIANSTFDICSNKDSETESLFSNVLVESNV----------- 830

  Fly   800 NHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNAQ----ISDLQQKVCPTDLDSRIRSLAEGV 860
                        ||       ::|..:.....|:..:    :|...:|..|
Mosquito   831 ------------DP-------QVLDKVLRRASMKGGKMTLSVSKENRKKSP-------------- 862

  Fly   861 QSLGES-RTVSKQLLKT------LVQQRRL------QASSLNEQRTTLDELRAQLLDAQQQEDAA 912
            :.:|:| |||::...:|      ::.:.|:      |||:.......|.:.||    |....|:.
Mosquito   863 KRIGKSPRTVNRSTSRTNSSASSVINRYRMMKAKDGQASTSGGTSAVLPKPRA----ANNNFDSD 923

  Fly   913 SKRLR 917
            |.|.|
Mosquito   924 SDRNR 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	125/355 (35%)
		Smc	<453..>985	CDD:440809	101/545 (19%)
		Metallothio	<1071..1115	CDD:395080
Klp67A	XP_308943.5	None