Protein Alignment Klp3A and Klp61F

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_061499619.1
• Gene: Klp61F / 1269725
• VectorBaseID: AGAMI1_012015
• Length: 1101
• Species: Anopheles gambiae
• Alignment Length: 1261
• Identity: 313/1261 - (24%)
• Similarity: 532/1261 - (42%)
• Gaps: 285/1261 - (22%)

  Fly     9 VAVALRVRPL-VQSELDRGCRIAVERSADGAPQVTVNRNES-----YTYNYVFDIDDSQKDLFET 67
            |.|.:||||. .:.:|.|...: ||..:....|:..|..:|     :|::..|..:..|.::::.
Mosquito    25 VQVYVRVRPTNAREKLIRSQEV-VEVVSTRELQLKSNYTDSRTSKKFTFDRTFAPNSKQHEVYQA 88

  Fly    68 CVQAKVKKLLNGYNVTILAYGQTGSGKTYTM--------GTAFNGVLDDHVGVIPRAVHDIFTAI 124
            .|...::::|:|:|.|:.||||||:|||:||        ..|:..  |...|:|||||:.:|..:
Mosquito    89 VVAPYIEEVLSGFNCTVFAYGQTGTGKTHTMVGEEEQNLSAAWED--DTQTGIIPRAVNHLFDEL 151

  Fly   125 AEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIR-----EVKNRIIMPGLTELVVTSAQ 184
              ..:|..|::..|::|||.|:..||.|  |.|  |:.||     :.|..:|:.||.|:.|.|..
Mosquito   152 --RMTELEFSMRISYLELYNEELCDLLS--TDD--TIKIRIFDDVQKKGSVIVQGLEEIPVHSKD 210

  Fly   185 QVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK---LDGKQSVTTSRFNLVDLAGSERC 246
            .|...|.:|...|..|:|.||..|||||.||:: :|..|   :||::.:...:.|||||||||..
Mosquito   211 DVYKLLAKGQERRKTASTLMNAQSSRSHTIFSI-IVHIKENGIDGEEMLKIGKLNLVDLAGSENI 274

  Fly   247 SKT-LASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIA 310
            ||. ...|.|.:|.||||:.||.||.||.||  .:...:||||:||||||||:||||.:.|.:||
Mosquito   275 SKAGNEKGIRTRETVNINQSLLTLGRVITAL--VEKTPHIPYRESKLTRLLQESLGGRTKTSIIA 337

  Fly   311 CVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLI 375
            .|||.:.:..||||||.||.||..|:|||..|       ..:.|..:.|...|
Mosquito   338 TVSPGNKDFEETLSTLEYAHRAKNIQNKPEAN-------QKLSKKTVIKEYTE------------ 383

  Fly   376 SAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNR-KLQQELHQSLLDLTEKEMRAHI 439
                                     ||.|||..:...:|:|. .|.:|.:..::..:|.     .
Mosquito   384 -------------------------EIDRLKRDLMAARDKNGIYLAEETYNEMVYKSEA-----A 418

  Fly   440 AEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHE 504
            .::.:||| :.:..||..|.::|                   .:.|.|...|...:|:|.....:
Mosquito   419 TKELNDKL-ALIKALKEDLARKE-------------------AIFNEVACSLAEREEQLRRTADD 463

  Fly   505 SRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFS 569
            ..|..:..|:|:          :.|......|..|::       .:...|..:|.|..:.....:
Mosquito   464 LGQTRAELSNTK----------KNLSKTKRRYVEKKV-------ILEHHLKTEQMLTGQAKELIN 511

  Fly   570 RLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISA--KLAEERRKRLQLLEQEISDLR 632
            .::|..||..             ...|.:|:.|.:.|::.||  :..:..|.|:..::.::|
Mosquito   512 VVESVTEDTN-------------GLHDTVDRRRELDSRNKSATEQFVDRVRHRIGTIQDDVS--- 560

  Fly   633 RKLITQANLLKI--------RDKERE--------KIQNLSTEIRTMKESKVKLIRA----MRGES 677
             |:..:.|.|.:        .:|::|        .:..|.|...::.:....|:.|    |.|::
Mosquito   561 -KMADECNRLTVDMNVGWESYNKQQEAAYIETKAHLSTLETVSHSLLQQNASLVGAFKASMEGKT 624

  Fly   678 EKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQAS 742
            |       .|..|:.|.  .|:..||.:...:|..|...: ||......:       ||...|..
Mosquito   625 E-------ARRDEVIQF--LDQVEQSRLALMETFTSTMEK-LKLGIRTTI-------DAQHEQVQ 672

  Fly   743 AQAQR---HKYKDNGGSAAGSSNAN-AKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYH 803
            ||.:|   |      |.|..|..|. .:|.:....||:.|.|..:..|:         |:.::..
Mosquito   673 AQFERMIAH------GQARESKCAEFCQTFTGQLAELDSITSTFERNHT---------VLQDYVA 722

  Fly   804 LLQQEKTSDPAEAAE-QARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESR 867
            ..:|:|.::.....| :|::.:.|.:.::...|  |..||    |:|.|.:..:::.:.|.|...
Mosquito   723 QSEQKKQNELKATKEFEAKVSSLLADFVQQMTA--SSQQQ----TELSSVVVHVSDELVSQGTKA 781

  Fly   868 TVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQR 932
            |...|.::          ||::|:|..:.|..|: .|:..||.|     ||:| ||      |::
Mosquito   782 TKQLQTIR----------SSIDEKRGKVQESTAE-WDSHAQECA-----RLVQ-QH------QRK 823

  Fly   933 AYEEKVSV-----------LIRTANQRWAEARSPAEDQQRNQILEEL-----------LSSREAL 975
            ..||..||           |..|..|:...| |.|:::.|..::|..           .:..|.:
Mosquito   824 VVEELASVDLSLAEVSNATLASTIEQQRTRA-STAQEETRACVVEFAQQFDEQNGNFGQAQEEGI 887

  Fly   976 QQELDKLRAKNKSKSK---AVKSEPQDLDDSFQIVD--GNETVVLSDVSD-------DPDWVPST 1028
            .:.:..|:.:.:::::   |.....|.:..:.:..:  .||..:....:|       |..:..|:
Mosquito   888 GRAMGSLQVQQQARAQFGSANCGHTQRIGQTVESFERRANEEQLAELQNDFERFHEKDLTFYQSS 952

  Fly  1029 SKS---KRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCG 1090
            .|:   |::|......::.|:::..........:.:...||:..||.:..  |......|..:..
Mosquito   953 GKTPIRKKVQYPRDIAMTSPDERILRRFWRERGATEVDLSTTICEDMEEI--CPLERSITNIKAP 1015

  Fly  1091 CLSGNNACSETCVCKSNCRNPLNLKDHASQCGDGD-GQK-------DETEDADKSDDD---GDDE 1144
            .:..:....:    :||..|....:.|..:....: |.|       :|:.:.:|.:::   ||..
Mosquito  1016 EIRNSTPLMQ----RSNMLNLDEERQHFKELQISNIGSKINSVQMLEESVEENKENNELINGDII 1076

  Fly  1145 PQTSKENAVKFVTP--EAPGKVVASP 1168
            ||..:||.:| ::|  |....:..||
Mosquito  1077 PQHKQENGIK-ISPQLEQASSITISP 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	140/349 (40%)
		Smc	<453..>985	CDD:440809	116/580 (20%)
		Metallothio	<1071..1115	CDD:395080	6/43 (14%)
Klp61F	XP_061499619.1	None