Protein Alignment Klp3A and Khc-73

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_061519501.1
• Gene: Khc-73 / 1269637
• VectorBaseID: AGAMI1_014561
• Length: 1913
• Species: Anopheles gambiae
• Alignment Length: 1261
• Identity: 307/1261 - (24%)
• Similarity: 520/1261 - (41%)
• Gaps: 266/1261 - (21%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQV-----TVNRNES-----YTYNYVFDIDD---- 59
            :.||:||||..:.||:......:|  .:|...:     ::::.|.     :.:::.|...|
Mosquito     5 IRVAVRVRPFNRRELELATENVIE--MNGTQTILKYPASLDKMERKPPKIFAFDHCFYSTDANAN 67

  Fly    60 ---SQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDI 120
               ||:.:|....:..::....|||..|.|||||||||:|| ||:      .|..|:|||...::
Mosquito    68 NFASQELVFNNIGRDILENAFQGYNACIFAYGQTGSGKSYTMMGS------QDSKGIIPRLCDEL 126

  Fly   121 FTAIAEMQS-EFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP---GLTELVVT 181
            |.:||..|: |..:.|..|::|:|.|:.:||...||. |.::.:||  :.::.|   ||::|.||
Mosquito   127 FASIAAKQTDELNYKVEVSYMEIYNEKVHDLLDPKTA-KQSLKVRE--HNVLGPYVDGLSQLAVT 188

  Fly   182 SAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVT---TSRFNLVDLAGS 243
            |...:.:.:..|:..|.||||.||..||||||:||:.|..|.:|....||   .||.:|||||||
Mosquito   189 SFLDIDNLMAEGNKSRTVAATNMNSESSRSHAVFTVVLTQTLIDTLSGVTGEKVSRVSLVDLAGS 253

  Fly   244 ERCSKTLASGDRFKEGVNINKGLLALGNVINAL----GSGQAAGYIPYRQSKLTRLLQDSLGGNS 304
            ||..||.|.|||.|||.||||.|..||.||:.|    |......::|||.|.||.||:|:|||||
Mosquito   254 ERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADSTGGKNKDKFVPYRDSVLTWLLKDNLGGNS 318

  Fly   305 ITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGK 369
            .|:|:|.:|||..|..||||||||||||.:|.|..|||.||:|..:..|:..::.|| |:|.
Mosquito   319 RTVMLATLSPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRKEVETLR-EMLK--- 379

  Fly   370 MSSSLISAVGA--AGLGAIPCEESLAGSMANAAEIQRLKEQV-RTLQDRNRK---LQQELHQSL- 427
                  .|.|:  ..:..:...:.|       ||.:.|.:|: :|.:::..|   :|.|..|:|
Mosquito   380 ------HATGSNFGDMKRVDIHDKL-------AESENLMKQISQTWEEKLEKTEQIQSERQQALE 431

  Fly   428 -LDLTEKEMRAHIAEQAHDKLRSHVSELKNKL---DQREQAQFGNENTNGDNEMRDFSLL---VN 485
             :.::.::....:.:..:..:..:.....|:|   ..:|:...|..:::| ::..|..||   :.
Mosquito   432 KMGISVQDSGIKVEKNKYYLVNLNADPSLNELLVYYLKEETLIGGRSSSG-SKQPDIQLLGLGIQ 495

  Fly   486 RVHVELQRTQEELESQGHESRQRLSSRSHTEGGESG-------GDEV-----HEMLHSHSEEYTN 538
            ..|..:.....||.....|     ::|.:..|....       ||.:     |....:..:..||
Mosquito   496 PEHCLITIEDGELYMDPIE-----NARCYVNGSVVSDKMALHHGDRILWGNHHFFRVNCPKSATN 555

  Fly   539 KQMNFAGELRNINRQLD---LKQELHERIMRN------FSRLDSD-DEDVKLRLCNQKIDDLEAE 593
            .....|.|.:...:.:|   .::||.:..:.|      .|||:.. :||.::.|..|:   .|.|
Mosquito   556 STALGASEPQTPAQHMDYYYAQEELMQNELSNNPIQAAISRLEKQHEEDKQVALEKQR---QEYE 617

  Fly   594 RRDLMDQLRNIKSKDI---------------------SAKLAEER--RKRLQLLEQEISDLR--- 632
            ::  ..|||||.|...                     :|:|..|:  ::|.::.::.:..|:
Mosquito   618 KQ--FQQLRNILSPTTPYAPYAPYDPFRLGKLPPNTPTAQLRVEKWAQERDEMFKRSLGQLKTDI 680

  Fly   633 ---RKLITQANLLKIRDKEREKIQ--------NLSTEIRT---MKESKVKLIRAMRGESEKFRQW 683
               ..|:.:||:|.....::.|..        |||...:.   :.|..: |:|.|...|:   .|
Mosquito   681 VRANALVQEANVLAEEMDKQTKFSVTLQIPPANLSPNRKRGAFVSEPAI-LVRRMNSGSQ---IW 741

  Fly   684 KMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALER-------QA 741
            .|             .|::::::..:.::...::..:...|||.|.:....::.|.       ..
Mosquito   742 SM-------------EKLENKLIDMRDMYQDYKERHQAAMEEAKAKSDPFYESQENHNLIGVANI 793

  Fly   742 SAQAQRHKYK--------DNGGSAAG-------------------SSNANAKTDSWVDRE----- 774
            ..:...|..|        ...|..||                   .|.:.:..||..|.|
Mosquito   794 FLEVLFHDVKLDYHTPIISQQGEVAGRLQVEISRVAGTFPQDRMCESASESSADSHEDDEDSPDT 858

  Fly   775 ----LEIILSLIDAEHSLEQLMEDRAVINN----HYHLLQQEKTSDPAEAAEQARILASLEEELE 831
                .....:.|....|::|.......::|    .|.....|....||...|.|....::..:.:
Mosquito   859 PSPPPPTNSNQISCRISIKQASGLPLYLSNFVFCQYSFWNHEVAVVPATNQEVAGHNQNITFKFD 923

  Fly   832 MRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLD 896
            .....|..:.::......|..:.....|.:|:|.||....:     |:|::.:|.||.::...|.
Mosquito   924 HEADYIVTMNEEFLEHCSDGALSIEVWGHRSVGFSRMKDWE-----VEQQQAKARSLADRWAELS 983

  Fly   897 ---ELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRW--------- 949
               ||..::.:.....|.|...::..:......:...::.::.:|.|.::......
Mosquito   984 RKIELWVEIHELNDNGDWAPVEVQCARDMLTGGVYQLRQGFQRRVMVRVKPVQNSGTLPIICQSI 1048

  Fly   950 -----------AEARSPAEDQQ-------RNQILEELLSSREALQQELDKLRAKNKSKSKAVKSE 996
                       ::.:.|.:..|       |::..|.|...|:.|.|::.:|..|: .|::..|..
Mosquito  1049 INVSMGCVTVRSKLQKPMDSYQEEDLTVLRDKWSEALGRRRQYLDQQIQRLINKD-DKTEQEKER 1112

  Fly   997 PQDLDDSFQIVDGNETVVL-----SDVSDDP-DWVPSTSKSKRIQSDSRNVISPPEKQDANVTSL 1055
            .|.|.:.:..:......||     |.:...| .|.|.......:         |....|.|...|
Mosquito  1113 EQSLVNQWVSLTEERNAVLVPAPGSGIPGAPASWDPPLGMEPHV---------PVLFLDLNADDL 1168

  Fly  1056 GNSSIQS-------LNSTSATEDGKR 1074
            ....:.:       |||....|.|.:
Mosquito  1169 STQGLSNDEVPMAGLNSILPKEHGNK 1194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	147/355 (41%)
		Smc	<453..>985	CDD:440809	114/676 (17%)
		Metallothio	<1071..1115	CDD:395080	1/4 (25%)
Khc-73	XP_061519501.1	None