Protein Alignment Klp3A and Kif5b

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_476550.1
• Gene: Kif5b / 117550
• RGDID: 621559
• Length: 963
• Species: Rattus norvegicus
• Alignment Length: 1096
• Identity: 289/1096 - (26%)
• Similarity: 483/1096 - (44%)
• Gaps: 294/1096 - (26%)

  Fly     5 DPS-C-VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFET 67
            ||: | :.|..|.|||.:||::||.:...:...:....:.   ::.|.::.||....||:.::..
  Rat     3 DPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIA---SKPYAFDRVFQSSTSQEQVYND 64

  Fly    68 CVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDD--HVGVIPRAVHDIFTAIAEMQSE 130
            |.:..||.:|.|||.||.|||||.||||:||    .|.|.|  .:|:|||.|.|||..|..|...
  Rat    65 CAKKIVKDVLEGYNGTIFAYGQTSSGKTHTM----EGKLHDPEGMGIIPRIVQDIFNYIYSMDEN 125

  Fly   131 FRFAVTCSFVELYQEQFYDLFS-SKTRDKATVDIREVKNRI-IMPGLTELVVTSAQQVTDHLIRG 193
            ..|.:..|:.|:|.::..||.. |||    .:.:.|.|||: .:.|.||..|.|..:|.|.:..|
  Rat   126 LEFHIKVSYFEIYLDKIRDLLDVSKT----NLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEG 186

  Fly   194 SAGRAVAATAMNETSSRSHAIFTL------TLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLAS 252
            .:.|.||.|.|||.|||||:||.:      |....||.||       ..||||||||:.|||.|.
  Rat   187 KSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGK-------LYLVDLAGSEKVSKTGAE 244

  Fly   253 GDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADY 317
            |....|..||||.|.||||||:||..|..  |:|||.||:||:||||||||..|.::.|.||:.|
  Rat   245 GAVLDEAKNINKSLSALGNVISALAEGST--YVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSY 307

  Fly   318 NVAETLSTLRYADRALQIKNKPVVNLDPHA----------AEVN-MLKDVIQ------------- 358
            |.:||.|||.:..||..|||...||::..|          .|.| .|::.||
  Rat   308 NESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGE 372

  Fly   359 -----------KLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQV--- 409
                       |..:|..:..| ..::.:...||.:|       :|||..: ||.::.:|::
  Rat   373 TVPIDEQFDKEKANLEAFTADK-DVAITNDKPAAAIG-------MAGSFTD-AERRKCEEEIAKL 428

  Fly   410 -RTLQDRNRKLQQE------LHQSLLDLTE---------KEMRAHI--AEQAHDKLRSHVSELKN 456
             :.|.|::.::.|:      |...:||..|         ..|:|.:  .:..:|..:..|.|:..
  Rat   429 YKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQ 493

  Fly   457 KLDQREQAQFGNENTNGDNEMRDFSLLVNR----------VHVELQRTQEELESQGHESRQRLSS 511
            .|::. ...:..::...:::.:::.||.:.          :..|||:.:|....|...:.:.::|
  Rat   494 ALEEL-AVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMAS 557

  Fly   512 --RSHTEGGES-GGDEVHE-----MLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNF 568
              :...|.|.: |.::|.:     |:   .||:|..::..:          .:|.|: :.:::..
  Rat   558 LLKDLAEIGIAVGNNDVKQPEGTGMI---DEEFTVARLYIS----------KMKSEV-KTMVKRC 608

  Fly   569 SRLDS---------DDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLL 624
            .:|:|         ::.:.:|..|..:|...||:.:.|.:.|:|:           |::||  .|
  Rat   609 KQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNV-----------EQKKR--QL 660

  Fly   625 EQEISDLRRKLITQANLLKIRDKEREKIQNLST----------EIRTMKESKVKLIRAMRGESEK 679
            |:.:..|..:|:......|:.:.|:|.:..:.|          :|::.:|:..|.|.::|.|.|
  Rat   661 EESVDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVE- 724

  Fly   680 FRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQ 744
                  .:||.:|.|:.:::||..|..|.:..|                  :||| |::::.|
  Rat   725 ------AKEKLITDLQDQNQKMVLEQERLRVEH------------------ERLK-AVDQEKS-- 762

  Fly   745 AQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEK 809
                                        |:|          |.| .:|:||
  Rat   763 ----------------------------RKL----------HEL-TVMQDR-------------- 774

  Fly   810 TSDPAEAAEQAR-ILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQL 873
                   .|||| .|..|||.:......:.:| :|:...||.:|::..|| |.|.....:.:::.
  Rat   775 -------REQARQDLKGLEETVAKELQTLHNL-RKLFVQDLATRVKKSAE-VDSDDTGGSAAQKQ 830

  Fly   874 LKTLVQQRRLQASSLNEQ--RTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEE 936
            ..:.::....|.:.:::|  |...| ||.:|...:::..|.::|::.|:|..:|   |::.|..:
  Rat   831 KISFLENNLEQLTKVHKQLVRDNAD-LRCELPKLEKRLRATAERVKALESALKE---AKENASRD 891

  Fly   937 KVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKA 992
                                               |:..|||:|:::...:||:.|
  Rat   892 -----------------------------------RKRYQQEVDRIKEAVRSKNMA 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	145/340 (43%)
		Smc	<453..>985	CDD:440809	105/571 (18%)
		Metallothio	<1071..1115	CDD:395080
Kif5b	NP_476550.1	KISc_KHC_KIF5	6..325	CDD:276820	145/338 (43%)
		SMC_prok_B	<414..803	CDD:274008	93/506 (18%)
		Khc_CBD_cc	834..903	CDD:467880	19/107 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963		3/5 (60%)
		Globular. /evidence=ECO:0000255	915..963