Protein Alignment Klp3A and Kif22

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_006507264.1
• Gene: Kif22 / 110033
• MGIID: 109233
• Length: 690
• Species: Mus musculus
• Alignment Length: 677
• Identity: 195/677 - (28%)
• Similarity: 310/677 - (45%)
• Gaps: 143/677 - (21%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVN-RNESYTYNYVFDI----DDSQKDLFETC 68
            |.||:|:||.:..|.: ...:...|:.|.......| :....|..|.||.    ..:|::::...
Mouse    39 VRVAVRLRPFMDGETE-AKELPCVRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYVGS 102

  Fly    69 VQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLDDHVGVIPRAVHDIFTAIAEMQSEFR 132
            ||..::.||.|.|.::||||.||:|||:|| |:      .:..||||||:.|:.....|..:|.|
Mouse   103 VQPILRHLLEGQNASVLAYGPTGAGKTHTMLGS------PEQPGVIPRALMDLLQLAREESAEGR 161

  Fly   133 ---FAVTCSFVELYQEQFYDLFSSKTRDKATVD--IRE-VKNRIIMPGLTELVVTSAQQVTDHLI 191
               .:|..|::|:|||:..||.     |.|:.|  ||| .:..|::||||:..:||......|.:
Mouse   162 PWDVSVAMSYLEIYQEKVLDLL-----DPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQHFL 221

  Fly   192 RGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSR-----FNLVDLAGSERCSKTLA 251
            ..|..|||.||.:|:.||||||:     :..|:|.::.:|..|     ..|:||||||...:|..
Mouse   222 PASRNRAVGATRLNQRSSRSHAV-----LLVKVDQRERLTPFRQREGKLYLIDLAGSEDNRRTGN 281

  Fly   252 SGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPAD 316
            .|.|.||...||..|..||.|::||..|...  ||||.|||||||||||||::.:::||.::|..
Mouse   282 QGIRLKESGAINTSLFVLGKVVDALNQGLPR--IPYRDSKLTRLLQDSLGGSAHSILIANIAPER 344

  Fly   317 YNVAETLSTLRYADRALQIKNKPVVN--LDPHA-AEVNM-LKDVIQKLRVELLSGGKMSSS---- 373
            ....:|:|.|.:..|:.::.|:|..|  |.||| |.|.: .|:::.....:...|.:..|:
Mouse   345 RFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKLSQKELLGPSEAKKAKGPEEESTGSPE 409

  Fly   374 ----------------LISAVGAAGLGAIPCEESLAGS-------MANAAEIQRLKEQVRTLQDR 415
                            .:|.:..|.|..:...|.|.||       :.|..:.:|: ..::|::::
Mouse   410 STAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGSQGTPLLNTPKRERM-VLMKTVEEK 473

  Fly   416 NRKLQQELHQSLLDLTEKEMRAHI-AEQAHDKLRSHVSELKNKLDQREQAQFGNENT-------- 471
            |.::::      |.:.:||:.|.: |::|.              |.||:     |||
Mouse   474 NLEIER------LKMKQKELEAKVLAQEAP--------------DPREK-----ENTPTILQPPA 513

  Fly   472 --NGDNEMRDFSLLVNRVHVELQRTQEELESQGH------ESRQRLSSRSHTEGGESGGDEVHEM 528
              :|...    ..|...|.:.|||.|::.||...      ..:::|.....:|..|.
Mouse   514 SYSGTVA----KPLKKAVVMPLQRIQKQRESSNQIQLLKKGPKRKLEPSPESEAVEK-------- 566

  Fly   529 LHSHSEEYTNKQMNFAGELRNINRQ--LDLKQELHERIMRNFSRLDSDDEDV-----KLRLCNQK 586
                .|:|...|:  :.||....|:  |||..|...|.:|:..|:......:     :|.....:
Mouse   567 ----DEDYWEVQI--SPELLAHGRKKLLDLLNEGSARELRSLQRIGQKKAQLIVGWRELHGPFSE 625

  Fly   587 IDDLEAERRDLMDQLRNIKSKDISAKL 613
            ::|||        |:..|..|.:.:.|
Mouse   626 VEDLE--------QVEGISGKQVESFL 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	127/343 (37%)
		Smc	<453..>985	CDD:440809	39/184 (21%)
		Metallothio	<1071..1115	CDD:395080
Kif22	XP_006507264.1	KISc_KID_like	38..361	CDD:276827	127/340 (37%)
		ComEA	591..641	CDD:441164	11/57 (19%)