DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp3A and KIF20A

DIOPT Version :10

Sequence 1:NP_525053.1 Gene:Klp3A / 31240 FlyBaseID:FBgn0011606 Length:1212 Species:Drosophila melanogaster
Sequence 2:NP_005724.1 Gene:KIF20A / 10112 HGNCID:9787 Length:890 Species:Homo sapiens


Alignment Length:910 Identity:209/910 - (22%)
Similarity:342/910 - (37%) Gaps:271/910 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEDPSCVAVALRVRPLVQSEL----DRGC-RI---------------AVERSADGAPQVTVNRN 46
            |.:....|.|.||||||:.|||    |:|| ||               |::.:..|..|.|    
Human    58 SEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSNERGIGQAT---- 118

  Fly    47 ESYTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLDDHV 110
            ..:|::.:|..:..|...|...|:..||.:|.|.|..|..||.|.||||:|: ||..:|      
Human   119 HRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDG------ 177

  Fly   111 GVIPRAVHDIF------------------------------------------------------ 121
            |::||::..||                                                      
Human   178 GILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGGLQEEELSTSLK 242

  Fly   122 ---------------------------------------------TAIAEMQSEFRFAVTCSFVE 141
                                                         ||...:.:..||::..||.|
Human   243 RSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLPVPANIRFSIWISFFE 307

  Fly   142 LYQEQFYDLFS--SKTRDKATVDIREVKN-RIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAATA 203
            :|.|..|||..  |:.|.:.|:.:.|.:| ...:..|..:.|..|::....|..|...::.|:|.
Human   308 IYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTH 372

  Fly   204 MNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLA 268
            :|:.|||||:||::.::..:.:|......|..:|.|||||||| |...||:|.||..|||..|..
Human   373 LNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERC-KDQKSGERLKEAGNINTSLHT 436

  Fly   269 LGNVINALGSGQ----AAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYA 329
            ||..|.||...|    ....:|:|.|||||:.|....|...:.||..|:|......|||...:::
Human   437 LGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFS 501

  Fly   330 DRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAG 394
            ..|.|:.:.|.:.|...:.. :.:|:...::...|..|.|..:.|...:          |.....
Human   502 AIASQLVHAPPMQLGFPSLH-SFIKEHSLQVSPSLEKGAKADTGLDDDI----------ENEADI 555

  Fly   395 SMANAAEIQRLKEQVRT--LQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHV-SELKN 456
            ||....|:.::.|.::|  |::|..|||.|:|                      ||..: :|:..
Human   556 SMYGKEELLQVVEAMKTLLLKERQEKLQLEMH----------------------LRDEICNEMVE 598

  Fly   457 KLDQREQAQFGNENTNGD--NEMRDFSL------LVNRVHVELQRTQ---EELESQGHESRQRLS 510
            ::.||||....:.:|..:  .||.:..|      |.:....|:|...   ||||:...|:||:  
Human   599 QMQQREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQEARQQ-- 661

  Fly   511 SRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDD 575
            |.:|.:.|.                                 :|.|::.  :|:..:.|.....:
Human   662 SVAHQQSGS---------------------------------ELALRRS--QRLAASASTQQLQE 691

  Fly   576 EDVKLRLCNQKIDDLEAERRDLMDQLRNIKSK-----DISAKLAEERRKRLQLLEQEI------- 628
            ...||:.|..:::....|.......|....|.     |:..|| ||.:|.::||..|:       
Human   692 VKAKLQQCKAELNSTTEELHKYQKMLEPPPSAKPFTIDVDKKL-EEGQKNIRLLRTELQKLGESL 755

  Fly   629 -------------SDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKF 680
                         ..||:.|.|..::|..:|:...::||....::.....|...|      :|::
Human   756 QSAERACCHSTGAGKLRQALTTCDDILIKQDQTLAELQNNMVLVKLDLRKKAACI------AEQY 814

  Fly   681 RQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQA 745
            .          |.|     |:|.::..::.|.:.|..  ::..::.......|::.|.|..:.|:
Human   815 H----------TVL-----KLQGQVSAKKRLGTNQEN--QQPNQQPPGKKPFLRNLLPRTPTCQS 862

  Fly   746  745
            Human   863  862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp3ANP_525053.1 KISc_KIF4 7..336 CDD:276823 124/455 (27%)
Smc <453..>985 CDD:440809 62/329 (19%)
Metallothio <1071..1115 CDD:395080
KIF20ANP_005724.1 KISc_KIF23_like 63..505 CDD:276819 122/452 (27%)
SMC_prok_B <547..>795 CDD:274008 63/317 (20%)
RBD_KIF20A 602..657 CDD:409645 15/54 (28%)
Globular. /evidence=ECO:0000255 763..890 21/123 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 832..865 5/33 (15%)
Blue background indicates that the domain is not in the aligned region.

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