Protein Alignment Klp3A and kif5c

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_002935337.3
• Gene: kif5c / 100493873
• XenbaseID: XB-GENE-977474
• Length: 959
• Species: Xenopus tropicalis
• Alignment Length: 1054
• Identity: 300/1054 - (28%)
• Similarity: 479/1054 - (45%)
• Gaps: 241/1054 - (22%)

  Fly     5 DPS-C-VAVALRVRPLVQSELDRGCR-IAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFE 66
            ||: | :.|..|.|||.::|:.||.: |.|.:..|   .|.|..::.|.::.||..:.:|:.::.
 Frog     3 DPAECSIKVMCRFRPLNKAEIQRGDKFIPVFKGED---TVVVGPSKPYVFDKVFPSNTTQEHVYS 64

  Fly    67 TCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDH--VGVIPRAVHDIFTAIAEMQS 129
            .|.:..||.:|:|||.||.|||||.||||:||    .|.|.||  :|:|||..||||..|..|..
 Frog    65 ACAKQIVKDVLDGYNGTIFAYGQTSSGKTHTM----EGKLHDHQMMGIIPRIAHDIFDHIYSMDE 125

  Fly   130 EFRFAVTCSFVELYQEQFYDLFS-SKTRDKATVDIREVKNRI-IMPGLTELVVTSAQQVTDHLIR 192
            ...|.:..|:.|:|.::..||.. |||    .:.:.|.|||: .:.|.||..|:|.::|.|.:..
 Frog   126 NLEFHIKVSYFEIYLDKIRDLLDVSKT----NLAVHEDKNRVPFVKGCTERFVSSPEEVMDVIDE 186

  Fly   193 GSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFK 257
            |.|.|.||.|.|||.|||||:||.:.:....::.::.: :.:..||||||||:.|||.|.|....
 Frog   187 GKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKL-SGKLYLVDLAGSEKVSKTGAEGAVLD 250

  Fly   258 EGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAET 322
            |..||||.|.||||||:||..|... ::|||.||:||:||||||||..|.:|.|.||:.:|.|||
 Frog   251 EAKNINKSLSALGNVISALAEGTKT-HVPYRDSKMTRILQDSLGGNCRTTIIICCSPSIFNEAET 314

  Fly   323 LSTLRYADRALQIKNKPVVNLDPHAAE-----------VNMLKDVIQKLRVELLSGGKMSSSLIS 376
            .|||.:..||..|||...|||:..|.|           ...||::||.|.:||....:..
 Frog   315 KSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKDKTKSLKNIIQHLEMELNRWRRGE----- 374

  Fly   377 AVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAE 441
                    |:|.:|..:.           |:| :||:..:.  ...:...|:..|      :|:.
 Frog   375 --------AVPVDEQTSA-----------KDQ-KTLEPCDN--TPVIDNGLVGAT------NISS 411

  Fly   442 QAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELES--QGHE 504
            :...|....::.|..:||.:            |:|:...|.|:.::..::...:|.|.|  :.:|
 Frog   412 EEKKKYDEDIASLYGQLDDK------------DDEINQQSQLIEKLKQQMLDQEELLASTRRDYE 464

  Fly   505 SRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFS 569
            ..|...:|...| .::..|||.|:|.:..|    ..:|:..:.:.:..:..|.::|.|.:
 Frog   465 KIQEELTRLQIE-NDAAKDEVKEVLQALEE----LAVNYDQKSQEVEDKTKLNEQLSEEL----- 519

  Fly   570 RLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKR----LQLLEQEISD 630
                          .||..:|...:|:| .||:         :|:..:|||    |.||.:::.:
 Frog   520 --------------TQKTTNLTVTQREL-SQLQ---------ELSNHQRKRTTEILNLLLKDLGE 560

  Fly   631 L-----RRKLITQANLLKIRDKE----REKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMV 686
            :     ...:.|.|.:..:.::|    |..|..:.:|::::.....:|..|....:.|..    .
 Frog   561 IGGIVGTNDVKTLAEVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQIEANRKIN----A 621

  Fly   687 REKELT--QLKSK--DRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQAS---AQ 744
            .||||.  ||.|.  :.|::|.....|.:..::||:     |||       :|||..:.:   ||
 Frog   622 SEKELAACQLLSSQHEAKIKSLTDYMQNMEQRRRQL-----EEA-------QDALNEELARLHAQ 674

  Fly   745 AQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEH---SLEQLMEDRAVINNHYHLLQ 806
            .:.||.                  |:.|:|.|.:..|.|||.   :|||.||      :|....|
 Frog   675 EKMHKV------------------SFQDKEKEHLTRLQDAEEIKKTLEQQME------SHREAHQ 715

  Fly   807 QEKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSK 871
            ::              |:.|.:|:|.:...|.||:      ||:.::       |...:..|...
 Frog   716 KQ--------------LSRLRDEIEEKQKMIDDLK------DLNQKL-------QLQLDKLTSDY 753

  Fly   872 QLLKTLVQQRRLQASS---LNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHE--EQMLA-- 929
            :.|||..:||......   |||:|....|      |.:..|:..::.|:.|.:..:  .|.||
 Frog   754 EKLKTEEEQREEDLQKLVLLNEKREQSRE------DLKGLEETVARELQTLHNLRKLFIQDLALR 812

  Fly   930 -QQR------------AYEEKVSVLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDK 981
             |:|            |.::|:|.|....             :|..::.::|:.....|:.||.|
 Frog   813 VQKRVELDSDNGGGSAAQKQKISFLENNL-------------EQLTKVHKQLVRDNADLRCELPK 864

  Fly   982 LRAKNKSKSKAVKS 995
            |..:.::.::.||:
 Frog   865 LEKRLRATAERVKA 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	145/335 (43%)
		Smc	<453..>985	CDD:440809	125/576 (22%)
		Metallothio	<1071..1115	CDD:395080
kif5c	XP_002935337.3	KISc_KHC_KIF5	6..327	CDD:276820	145/333 (44%)
		EnvC	452..>676	CDD:443969	60/273 (22%)
		SMC_prok_B	580..>912	CDD:274008	87/385 (23%)
		Khc_CBD_cc	836..905	CDD:467880	10/56 (18%)