Protein Alignment Klp3A and kif14

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_004913798.2
• Gene: kif14 / 100493263
• XenbaseID: XB-GENE-981231
• Length: 1609
• Species: Xenopus tropicalis
• Alignment Length: 1292
• Identity: 328/1292 - (25%)
• Similarity: 517/1292 - (40%)
• Gaps: 372/1292 - (28%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDS------------- 60
            |.||:||||..:.|::..   ||:.......:.||...:| ..||:|..|.|
 Frog   347 VTVAVRVRPFSKREVNEK---AVQVVFMNGQETTVQHPDS-KQNYIFCYDFSFWSFEKSQPSFVG 407

  Fly    61 QKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAI- 124
            |..::|......::..|.|||..:.|||||||||:||| ..|:|    ..|:|||...|:|:.|
 Frog   408 QASVYEKLAVPLLEWSLLGYNTCLFAYGQTGSGKSYTM-MGFDG----EPGIIPRFCSDLFSRIQ 467

  Fly   125 AEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRD---KATVDIREVKNRIIMPGLTEL---VVTSA 183
            |.|:.:..|.:..|:.|:|.|:.:||...|..:   |..:.:||  :.:..|.:.:|   ||:|.
 Frog   468 ATMKQKLSFHLEISYFEVYNEKIHDLLIFKAENGQKKQPLKVRE--HPLTGPYVEDLSMNVVSSF 530

  Fly   184 QQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK---LDGKQ--SVTTSRFNLVDLAGS 243
            |.:...|..|:..||.|||.||:.|||||::|||.:..||   :||::  ...|||.||||||||
 Frog   531 QDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEYVDGQEHDHRITSRINLVDLAGS 595

  Fly   244 ERCSKTLASGDRFKEGVNINKGLLALGNVINALGSG---QAAGYIPYRQSKLTRLLQDSLGGNSI 305
            ||||....||:|.||||:|||.||.||.||:||...   :...:||||:|.||.||::||||||.
 Frog   596 ERCSTAQTSGERLKEGVSINKSLLTLGKVISALSENSQTRKKTFIPYRESVLTWLLKESLGGNSK 660

  Fly   306 TLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKM 370
            |.|||.:|||..|:.|||||||||.:|..|.|...||.|.:|..:..||..|:|::...||....
 Frog   661 TSMIATISPAATNMEETLSTLRYAKQARLIINVAKVNEDLNAKIIRELKAEIEKMKASQLSAKNK 725

  Fly   371 SSSLISAVGAAGLGAIPCEE-------SLAGSMANAAEIQRL-KEQVRTLQDRNRKLQQELHQ-- 425
            .|....          .|.:       .|.......:|::|. |:::...:.|.:...|||.:
 Frog   726 DSEKYR----------QCHQEVTSLKLKLCQQEREMSELRRAWKDKLEQAEQRKKVEMQELQKAG 780

  Fly   426 ----------SLLDLTE----KEMRAHIAEQAHDKL------RSHVSELKNKLDQREQA------ 464
                      :|::|.|    .||..::.::....:      .||..:|...|...:..
 Frog   781 ITFKMDNRLPNLVNLNEDPQLSEMLLYMIKEGQTTVGKYKAGSSHDIQLSGALIAEDHCIITNNE 845

  Fly   465 ------QFGNENT---------------------NGDNEMR-DFSLLVNRVH------------- 488
                  .||:..|                     .||:..| :..:.|||::
 Frog   846 NIVCIKPFGDAKTYVNGNQISGSTILHHGDRLILGGDHYFRVNHPMEVNRLNATTQVSDGPKDYE 910

  Fly   489 ------VELQRTQ--EELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAG 545
                  :..||:|  ||:|    |:|.| :.....||.:...:...:.|.|....|..|..:...
 Frog   911 FAKNELLSAQRSQLAEEIE----EARLR-AKEEMMEGIQIAKEMAQQELTSQKFAYEEKIRDLEA 970

  Fly   546 ELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRL-----CNQKIDDLE--AERRDLMDQLRN 603
            :|:..::..:|::...:|.......|    |::|:.|     .|:|..::|  |.::.|.|  .|
 Frog   971 QLKKESQHKELQEMNSQRATTRIQEL----EEMKIHLQQEVQFNKKRLEMETLATKQALED--HN 1029

  Fly   604 IK-SKDISAKLAEERR--KRLQLLEQEISDLRRK--------------LITQANLLK-------- 643
            :: :|.:.|..||:::  |.:|:|::|.:...|.              :|.:||.:.
 Frog  1030 VRHAKILQALEAEKQKIAKEVQMLQRERNSQDRAMAVQPTWNNMKLSVMIQEANSISSKLKKHTV 1094

  Fly   644 -----IRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKEL------------ 691
                 :.|||     ||.|....::...:||........||| ::|:...|:|
 Frog  1095 FSRHDVTDKE-----NLPTNPVQIQVKNLKLGIVTYWSLEKF-EYKLAAMKDLYENHGSTKDDDV 1153

  Fly   692 --------------------TQLKS--KDRKM-----QSEIVRQQTLHSKQRQVLKRK------C 723
                                ::.||  |:|::     :..:...|:|.|.....|..|      |
 Frog  1154 FYDPGDEWEPDLSNTSVSRFSRRKSLMKNRRISGCLYEIRVHPIQSLQSGHASGLMNKSSSFLSC 1218

  Fly   724 EEALAANKR-------LKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSL 781
            ..::::|..       .||.:........:.|..:.|            ..||.:|......:.:
 Frog  1219 SSSVSSNPSDSHLPGICKDLIASSLDYLGRSHVDESN------------MADSMIDSVKRACIGV 1271

  Fly   782 IDAEHSLEQLMEDR-------------------------AVINNHY------------------- 802
            .....:.||..||.                         .|:|.|:
 Frog  1272 RTVSQAYEQQKEDSTDMLFLANREAQSHSVQLTSAFQQLVVLNKHWPRLLPEIQEMTKPADNVSL 1336

  Fly   803 ---------HLLQQEKTSDPAEAAEQAR---------ILASLEEELEMRNAQISDLQQKV-CPTD 848
                     .||.|..|||.|....:||         ||.::.:...:.|.::..|:::: ...|
 Frog  1337 YIRKLGGYLQLLLQGCTSDIASMVTEARDKSFHIAEQILQNIGQLAALTNTELHFLEEELKDEKD 1401

  Fly   849 LDSRI-RSLAE----GVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQL------ 902
            |.... ||::|    |:||:.||...:...:.|.:|:..:|...|.|.:|....|...|
 Frog  1402 LQKLFSRSVSEGLRFGLQSIMESVLKATHDIYTHIQRFIVQDEHLTEIKTNAIRLTTFLQKCLAN 1466

  Fly   903 -----LDAQQQEDAASKR------LRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPA 956
                 |:...::...|.|      ||.|:|..:...||...|.|             .|:|..|.
 Frog  1467 CVKLDLNILLKDSVFSIRSSLTIGLRNLRSIMDRLRLAVVSALE-------------GADADVPI 1518

  Fly   957 EDQQRNQILE---------ELLSSR-------EALQQEL------DKLRAKNKSKSK 991
            ....::.|:|         .|||.:       |||.|.|      :::....:||.:
 Frog  1519 LLSLKHDIVECSSQINRNLLLLSPQVIGLQDLEALTQSLMQCLCREQVAGPRRSKEQ 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	151/354 (43%)
		Smc	<453..>985	CDD:440809	146/782 (19%)
		Metallothio	<1071..1115	CDD:395080
kif14	XP_004913798.2	KISc_KIF1A_KIF1B	347..697	CDD:276816	153/360 (43%)
		Kinesin_assoc	694..812	CDD:465047	25/127 (20%)
		FHA_KIF14	783..890	CDD:438759	15/106 (14%)
		Smc	<912..>1063	CDD:440809	37/161 (23%)