Protein Alignment Klp3A and kif13b

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: XP_031758942.1
• Gene: kif13b / 100492799
• XenbaseID: XB-GENE-956968
• Length: 1943
• Species: Xenopus tropicalis
• Alignment Length: 1509
• Identity: 366/1509 - (24%)
• Similarity: 574/1509 - (38%)
• Gaps: 422/1509 - (27%)

  Fly     7 SCVAVALRVRPLVQSELD--RGCRIAVERS---------------ADGAPQVTVNRNESYTYNYV 54
            |.|.||:|:||:.:.|:|  ..|.:.||.:               |...|:|       :.|::.
 Frog     4 STVKVAVRIRPMNRREVDLQTKCVVDVENNQIVLYPSNASLSKGDARSQPKV-------FAYDHC 61

  Fly    55 F-DIDDSQKDLFE------TCVQAKV-KKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHV 110
            | .:|:|.|:.|.      .|:...: :....|||..|.|||||||||:|| ||||      |..
 Frog    62 FWSMDESVKEKFAGQDVVFQCLGENILQNAFEGYNACIFAYGQTGSGKSYTMMGTA------DQP 120

  Fly   111 GVIPRAVHDIF--TAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMP 173
            |:|||....:|  |..|| ..|..|.|..||:|:|.|:..||...| ..:.::.:||  ::::.|
 Frog   121 GLIPRLCSTLFERTQKAE-NEELSFKVEVSFMEIYNEKVRDLLDPK-GSRQSLKVRE--HKVLGP 181

  Fly   174 ---GLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVT---T 232
               ||::|.|||.:.:...:..|:..|.||||.|||.||||||:|.:.|..|.:|.|...:   .
 Frog   182 YVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLVDVKSGTSGEKV 246

  Fly   233 SRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQAAG-----YIPYRQSKL 292
            |:.:|||||||||.:||.|:|:|.|||.||||.|..||.||:|| :.|.||     ::|||.|.|
 Frog   247 SKLSLVDLAGSERATKTGAAGERLKEGSNINKSLTTLGLVISAL-ADQGAGKNKNKFVPYRDSVL 310

  Fly   293 TRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVI 357
            |.||:|||||||.|.|:|.||||..|..||||||||||||..|.|..|||.||:|..:..|::.:
 Frog   311 TWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKNIVNHAVVNEDPNARIIRELREEV 375

  Fly   358 QKLRVELLSGGKM-----------SSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVR- 410
            :||||:|.....|           |..||..:      .:..||.|..:...|.|.|:..|.:.
 Frog   376 EKLRVQLTQAESMKAPELKERLQESEKLIQEM------TVTWEEKLRMTEDIAQERQKQLESLGI 434

  Fly   411 TLQDR------NRKLQQELH--QSLLDLTEKEMRAHIAEQAHDK----------LRSH------- 450
            :||..      |:.....|:  .:|.:|....::.|....:||.          |..|
 Frog   435 SLQSSGIKVGDNKSFLVNLNADPALNELLVYYLKDHTLIGSHDSQDIQLCGLGILPEHCIIDISP 499

  Fly   451 -----VSELKN--------KLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQG 502
                 ::.:||        .:.:..|.|.|:....|:|.....||      .:.::.::|.|.|.
 Frog   500 EGQVILTPMKNTRTYVNGSAVTKATQLQHGDRILWGNNHFFRISL------PKKKKAKQEDEEQD 558

  Fly   503 HESRQR-------LSSRSHTEGGE------------------SGGDEVHEMLHS----HSEE--- 535
            ...|..       |...|.:||..                  ...|.:..:|.|    |.||
 Frog   559 SSLRNSSSFEQLDLDGDSSSEGSSEVNFNYEYAQMEIMMKALGNNDPMQSILQSLEQQHEEEKRS 623

  Fly   536 -YTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMD 599
             ...:::.:..||..:.|:|..::: |.|.|..|| ..|.:       ..|:|.....||..:::
 Frog   624 ALERQRLMYEHELDQLRRRLSPEKQ-HYRSMDRFS-FGSPN-------AQQRIRQWTEEREAMLN 679

  Fly   600 Q-LRNIKSKDISAKL--------AEERRKR------LQLLEQEI-SDLRRKLITQANLLKIRDKE 648
            | ||.::.:...|.|        |||..||      ||:....: ::.:|..:.....:::|.|.
 Frog   680 QSLRKLREQIAKANLHVQEANFIAEEMDKRTEYKVTLQIPASSLNANKKRGAVLSEPAIQVRRKG 744

  Fly   649 R-------EKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQ---- 702
            :       ||::|...:||.:                 :::||...|.: ...:|..|:..
 Frog   745 KGKQIWSLEKLENRLVDIRDL-----------------YQEWKECDEDD-PMSRSYFRRADPFYD 791

  Fly   703 ----------SEIVRQQTLHSKQRQ----VLKRK-----------------CEEALAANKRLKDA 736
                      :.:..:...|..:.|    ::.:|                 .|:.:|..   :|.
 Frog   792 EHENHSLIGVANVFLESLFHDVKLQYAVPIINQKGEVAGRLHVEVVRISGDIEDRIAGG---EDG 853

  Fly   737 LERQASAQAQRHK--------------------------YKDNGGSAAGSSNANAK------TDS 769
            .:.....:||.:|                          :.|.......:...:..      |:.
 Frog   854 ADFSFEKEAQENKLVCMIKVLQATGLPQHLTNFVFCHYIFWDQPEPTTVAPEVDTAPPVIKGTEC 918

  Fly   770 WV--DRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAE-------AAEQARILAS 825
            .|  |...|.::::  .|..||.|.|....|..:.|     :.|||..       ...||:..:.
 Frog   919 MVVFDHCKEFVVNI--TEDFLEYLSEGALAIEVYGH-----RQSDPHRNPALWDLGIIQAKTRSL 976

  Fly   826 LEEELEMRN-----AQISDLQQ--KVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRL 883
            .:...|:..     .||.:|.:  :.||.::.........|:..|.:.            |.|||
 Frog   977 RDRWSEVTRKVELWVQILELNENGEYCPVEVTPAKDVQTGGIYQLKQG------------QSRRL 1029

  Fly   884 QASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQR 948
            .                  ::|:..:|:.:  |.|:    |:.:|:......:.|:.....|:..
 Frog  1030 H------------------IEARSVQDSGT--LPLI----EDSILSISIGCVKIVNAKAIKAHDF 1070

  Fly   949 WAEARSPAEDQQ-------RNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQI 1006
            ..:||...:..|       |.:.|..|...:|.|.|:|.||.:|..........|.|.|:....:
 Frog  1071 HQDAREDVDSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKQDKSEDDADREAQLLEMRLTL 1135

  Fly  1007 VDGNETVVL----SDVSDDP-DWVPSTSKSKRI--------------QSDSRNVISPPEKQDANV 1052
            .:....|::    |.:...| :|.|.:.....|              |.|...:  .|...|:.:
 Frog  1136 TEERNAVMVPSAGSGIPGAPANWTPVSGMETHIPVIFLDLNVDDFSSQDDLDGL--EPAGWDSTL 1198

  Fly  1053 TSLGNSSIQSLNSTSATEDGKRCKGCKCRTKCTTKRCGCLSGNNACS------------------ 1099
            ||........|......|...:   .:....||...|..||..:|..
 Frog  1199 TSEDEGEFFDLQIVKHHESEVK---AEASWDCTVHNCPQLSKGSAPEDRVFLIVRATVQLSHPAE 1260

  Fly  1100 -ETCVCKSNCRNPLNLKDHA-------------SQCG-----------DGDGQKD---------E 1130
             :..:.|..|.|..:.:..|             |.||           |..|.:|         .
 Frog  1261 MQIVLRKRICVNVYSRQGFAQSFLRRMSHRSSISSCGVTVEVVSNIPEDSQGAEDREALARMAAN 1325

  Fly  1131 TEDADKSDDDGDDEPQTSKENAVK-FVTPEAPGKVVASPKQTLQEPKAAATPLMNSNV------V 1188
            .||...:|.:...|.......||: .:|.:...:.||..:|...:.|.....|.:.||      .
 Frog  1326 VEDTGSADSEAYIEKYLRSVLAVENILTLDRLRQEVAVKEQLTGKGKLHRKSLSSPNVHRLSGSR 1390

  Fly  1189 EDINGPK-LAKMSG 1201
            :|:.|.: ||...|
 Frog  1391 QDLGGQQSLASNKG 1404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	157/367 (43%)
		Smc	<453..>985	CDD:440809	120/685 (18%)
		Metallothio	<1071..1115	CDD:395080	9/62 (15%)
kif13b	XP_031758942.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	160/373 (43%)
		Kinesin_assoc	357..469	CDD:465047	29/117 (25%)
		FHA_KIF13B	447..545	CDD:438782	17/103 (17%)
		DUF3584	<589..>867	CDD:432349	53/307 (17%)
		KIF1B	755..801	CDD:463574	8/63 (13%)
		DUF3694	1001..>1055	CDD:463599	14/89 (16%)
		bMERB_dom	<1097..1141	CDD:463467	11/43 (26%)
		DUF3694	<1185..1276	CDD:463599	16/95 (17%)
		CAP_GLY	1810..1873	CDD:460154