DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and kif21a

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001182593.1	Gene:	kif21a / 100485713	XenbaseID:	XB-GENE-1010599	Length:	1662	Species:	Xenopus tropicalis

Alignment Length:	1361	Identity:	366/1361 - (26%)
Similarity:	589/1361 - (43%)	Gaps:	311/1361 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFET 67
            ::|.|.|.||||:||.:..|...||.|... ...|.|||.:.:::::|::||||||..|::::..
Frog     4 AQDDSAVRVALRIRPQLAKEKIEGCHICTS-VTPGEPQVVLGKDKAFTFDYVFDIDSRQEEIYMQ 67

  Fly    68 CVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFN-GVLDDHVGVIPRAVHDIFTAIAEMQSEF 131
            |.:..::....|||.|:.||||||:||||||||.|: .:.::..|:|||||..:|..|.| :.:|
Frog    68 CTEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNISEEEHGIIPRAVTHLFRRIEE-KKQF 131

  Fly   132 R---------FAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNR----------IIMPGLTE 177
            .         |.|...|:|||.|:..|||.: |||   :|.|..|:.          |...|:|.
Frog   132 ALEQGLPPPDFKVNAQFLELYNEEVLDLFDT-TRD---IDARNKKSNIRIHEDSSGGIYTVGVTT 192

  Fly   178 LVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTL----VATKLDGKQSV-------- 230
            ..|:|..::...|..|:..|..|:|.||..|||||||||:.|    |..|:|.:..:
Frog   193 RNVSSETEMIQCLKIGALSRTTASTQMNVQSSRSHAIFTIHLCQNRVCPKIDNENDLDNRMASES 257

  Fly   231 --------TTSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG-SGQAAGYIP 286
                    .|::|:.||||||||..:|.|:|:|.|||::||.|||||||||:||| ..:.|.::|
Frog   258 NQINEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKKATHVP 322

  Fly   287 YRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVN 351
            ||.|||||||||||||||.|:|||||||:|.:..|||:||:||:||..||||.:||.|..:.::|
Frog   323 YRDSKLTRLLQDSLGGNSQTVMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRTSQQIN 387

  Fly   352 MLKDVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMAN--AAEIQRLKEQVRTLQD 414
            .|::.|.:|::||:. .|....:|...|...:..:..|.::..:..|  ...|:.::|.:..|:.
Frog   388 ALRNEIARLQMELME-YKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETIDALRS 451

  Fly   415 R-------------------NRKLQQELHQSLLDLTEKEMRAHI--AEQAHDKLRSHVS------ 452
            |                   |.::...:|..:.::  :::||.:  :|..::.||..:|
Frog   452 RITQLMSDQANQVLSRSGDGNEEISNMIHNYIKEI--EDLRAKLLESEAVNENLRKSLSRASSRS 514

  Fly   453 -------------------------------ELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNR 486
                                           |...|::::::.....|. |.|||..:
Frog   515 SYFPAHTPFPTSLIAAEQETNEIIDMAKKDLEKLKKIEKKKKKSIVKEE-NPDNEKLE------- 571

  Fly   487 VHVELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHS-----HSEEYTNKQMNFAGE 546
               |...|::|......|.|.     .|.|..|...:|..|.:.:     .|:....::.|:..:
Frog   572 ---EKDNTEKECHDLVIEERS-----DHEEDEEEEEEEEDEDVDAAESSDDSDSELEEKENYQAD 628

  Fly   547 LRNINRQLDLKQELHERIMRNFSRLDS--DDEDVKLRLCNQKIDDLEAERRDLMDQLRNIK--SK 607
            |.||..::.:||:|.:.:..:..||.:  ...:.||.....||.|.:.||..::..:.:::  ::
Frog   629 LANITCEIAIKQKLIDELENSQRRLHTLKQQYEEKLMTLQNKIKDTQLERDRVLQNMGSMETCTE 693

  Fly   608 DISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRA 672
            :.:.|:..|..|:||.:.:|:..|:......|.|||.:.:..::::.|..|:..||::||:|::.
Frog   694 EKAKKIKVEYEKKLQTMNKELQKLQAAQKEHARLLKNQSQYEKQMKKLQQEVVEMKKTKVRLMKQ 758

  Fly   673 MRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDAL 737
            |:.|.||.|..:..|.:|:.|||...||..|::...:....:|..||:||.||..|..::::...
Frog   759 MKEEQEKARVTETRRNREIAQLKKDQRKRDSQLRLLEAQKKQQEVVLRRKTEEVTALRRQVRPMS 823

  Fly   738 ERQAS--------------------------------------AQAQ----------RHKYKDNG 754
            :|.|.                                      |:.|          |.||:..|
Frog   824 DRVAGRVGRKISLPEPIAEHISNMPEELDSTKHGLQQKPRIPVARVQPATSTALNGTRKKYQRKG 888

  Fly   755 GSAAGSSNANAKTDSWVDRELEII---LSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEA 816
            .|:..|..|..|..|...|..:|:   :::.:.|..:.:|::.|..:......:.:::.....|:
Frog   889 VSSYTSKAARQKWQSLERRITDIVMQRMTISNMEVDMNRLLKQREELTKRKEKVSKKRDRILKES 953

  Fly   817 AEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSKQLLKTLVQQR 881
            .:..:.:.||.||:|..||.|..|...:  :|..:.|..:.|           :|:...||....
Frog   954 GDADKNIHSLSEEMESLNANIDYLNDSI--SDCQASIMQMEE-----------AKEEGDTLDVTA 1005

  Fly   882 RLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTAN 946
            .:.:.:|.|.|..||.....         |.||.|:..|.:.:.::|..:....|     |.:|.
Frog  1006 VISSCTLTEARYLLDHFLNM---------AVSKSLQAAQREAQIKVLEGRLKQTE-----ITSAT 1056

  Fly   947 QRWAEARSPAEDQQRNQILEELLSSREALQQELDKL--------------RAKNKSKSKAVKSEP 997
            |              ||:|..:|..:..|..|||.|              .|:|.|
Frog  1057 Q--------------NQLLFHMLKEKAELNPELDALLGHALQDLDSIPLENAENSS--------- 1098

  Fly   998 QDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKR--------IQSDSRNVISPPEKQDANV-- 1052
             |.|.|.|........:.||:......|...||::|        :.:||..  |.|:......
Frog  1099 -DDDGSLQSPSTEGGSLTSDLMKLCGEVKPKSKARRRTTTQLELLYADSSE--STPDAGTGETCI 1160

  Fly  1053 -TSL---GNSSIQSLNSTSATEDGKRCK----GCKCRTKCTTKRCGCLSGNNACSETCVCKSNCR 1109
             |||   ....:..||..|:....|..:    |...||...:|
Frog  1161 PTSLPPVSEMQVSGLNIESSVNTVKEKEMLHSGIPSRTGSISK---------------------- 1203

  Fly  1110 NPLNLKDH---------ASQCGDGDGQKDETEDADKSDDDGDDEPQTSKENAVKFVTPEAP 1161
             |:.|.|.         ..:..|..|.|.......|..|.|..|...|        .|.:|
Frog  1204 -PVTLTDKRIPEQSPATRRRVYDKGGDKSIKNKEQKFSDSGTSEASLS--------PPSSP 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	163/369 (44%)
		Kinesin	14..335	CDD:278646	158/361 (44%)
		Smc	<396..>994	CDD:224117	147/731 (20%)
		FlaC	522..633	CDD:225888	26/119 (22%)
		TCR	1075..1110	CDD:281618	4/38 (11%)
kif21a	NP_001182593.1	KISc_KIF4	8..372	CDD:276823	163/369 (44%)
		KISc	9..378	CDD:214526	166/374 (44%)
		GBP_C	<640..784	CDD:303769	39/143 (27%)
		Rabaptin	666..1130	CDD:281520	112/514 (22%)
		coiled coil	759..769	CDD:293879	5/9 (56%)
		WD40	<1320..1645	CDD:225201
		WD40	1327..1640	CDD:238121
		WD40 repeat	1339..1373	CDD:293791
		WD40 repeat	1378..1415	CDD:293791
		WD40 repeat	1443..1478	CDD:293791
		WD40 repeat	1483..1527	CDD:293791
		WD40 repeat	1535..1568	CDD:293791
		WD40 repeat	1575..1611	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D74122at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010