DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egh and bre-3

DIOPT Version :9

Sequence 1:	NP_001284829.1	Gene:	egh / 31239	FlyBaseID:	FBgn0001404	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_499087.2	Gene:	bre-3 / 176332	WormBaseID:	WBGene00000268	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	455	Identity:	273/455 - (60%)
Similarity:	342/455 - (75%)	Gaps:	1/455 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSTTKHLLHCTLLITVIVTFEVFSGGIKIDENSFTLVDPWTEYGQLATVLLYLLRFLTLLTLPQ 65
            ||...||.|||.:|:..||.|..|.|.............|...||.:.||.||||||..||.|||
Worm     1 MNCEVKHALHCAVLVAWIVCFAYFCGVFTEPVEGSVPESPVASYGLIWTVCLYLLRFTALLVLPQ 65

  Fly    66 VLFNFCGLVFYNAFPEKVVLKGSPLLAPFICIRVVTRGDFPDLVKTNVLRNMNTCLDTGLENFLI 130
            .|.|..||:.:|||.|||.||.:|||:||:|.||||:|:||.|||.|:..||.||.:.|:|||:.
Worm    66 CLCNLGGLMMFNAFREKVQLKAAPLLSPFVCFRVVTKGNFPLLVKENIDTNMKTCFEAGMENFIF 130

  Fly   131 EVVTDKAVNLSQHRRIREIVVPKEYKTRTGALFKSRALQYCLEDNVNVLNDSDWIVHLDEETLLT 195
            |||||||:||..:.|:||:|||..|||::||.||:|||||||||:||:|..:|||||||||||||
Worm   131 EVVTDKAINLPPNPRVREVVVPTVYKTKSGAKFKARALQYCLEDDVNILQPTDWIVHLDEETLLT 195

  Fly   196 ENSVRGIINFVLDGKHPFGQGLITYANENVVNWLTTLADSFRVSDDMGKLRLQFKLFHKPLFSWK 260
            .|::.||:||..||||.||||:|||||.::|||||||:|||||:|||||||.||||||||||.||
Worm   196 TNAICGILNFCEDGKHQFGQGVITYANGDIVNWLTTLSDSFRVADDMGKLRFQFKLFHKPLFGWK 260

  Fly   261 GSYVVTQVSAERSVSFDNGIDGSVAEDCFFAMRAFSQGYTFNFIEGEMYEKSPFTLLDFLQQRKR 325
            ||||||||.|||.||:|:|::||:||||||:|.|...||:|:||||||:||||||:.||||||||
Worm   261 GSYVVTQVEAERDVSYDHGMEGSIAEDCFFSMVAMKHGYSFDFIEGEMHEKSPFTMWDFLQQRKR 325

  Fly   326 WLQGILLVVHSKMIPFKHKLLLGISVYSWVTMPLSTSNIIFAALYPIPCPNLVDFVCAFIAAINI 390
            |||||||.|||..|...||.||.:|:|:|.||||::..:....|:|:|.....||:.:|:.|:|:
Worm   326 WLQGILLTVHSSKIAVVHKALLALSLYAWATMPLTSLQVFLCPLFPLPRCLPFDFLLSFVGALNL 390

  Fly   391 YMYVFGVIKSFS-LYRFGLFRFLACVLGAVCTIPVNVVIENVAVIWGLVGKKHKFYVVQKDVRVL 454
            |||:|||:|||| .||..|.|....:.||:.|||.|::|||.||:.|:.|:|.:||:|.||::.:
Worm   391 YMYIFGVVKSFSHKYRNSLLRLAMYLAGALMTIPFNILIENAAVLVGMFGRKDQFYIVNKDIQTV 455

Fly 455 454
Worm 456 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egh	NP_001284829.1	Glyco_trans_2_3	184..372	CDD:290360	132/187 (71%)
egh	NP_001284829.1	BcsA	<283..435	CDD:224136	87/152 (57%)
bre-3	NP_499087.2	BcsA	<154..453	CDD:224136	192/298 (64%)
bre-3	NP_499087.2	Glyco_trans_2_3	184..382	CDD:290360	136/197 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164683
Domainoid	1	1.000	317	1.000	Domainoid score	I681
eggNOG	1	0.900	-	-		E1_2CN2A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14769
Inparanoid	1	1.050	568	1.000	Inparanoid score	I584
Isobase	1	0.950	-	0	Normalized mean entropy	S12198
OMA	1	1.010	-	-		QHG28681
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016724
OrthoInspector	1	1.000	-	-		oto17607
orthoMCL	1	0.900	-	-		OOG6_107914
Panther	1	1.100	-	-	LDO	PTHR16779
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16889
SonicParanoid	1	1.000	-	-		X13572
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.780