Protein Alignment Pdfr and Glp2r

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_783612.2
• Gene: Glp2r / 93896
• MGIID: 2136733
• Length: 512
• Species: Mus musculus
• Alignment Length: 463
• Identity: 121/463 - (26%)
• Similarity: 201/463 - (43%)
• Gaps: 72/463 - (15%)

  Fly   212 TGLYCNWTWDTLLCWPPTPAGVLARMNCPG--GFHGVDTRKFAIRKCELDGRWGSRPNATEVNPP 274
            :|::||.|:|..:|||.:..|.:: :.||.  .:...::...|.|.|...|.|..:.|:|:.
Mouse    52 SGVFCNGTFDKYVCWPHSFPGNVS-VPCPSYLPWWNKESPGRAYRHCLAQGTWQKQENSTDT--- 112

  Fly   275 GWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRT--RTLEI---VGLCLSLFALIVSLLIFCTF 334
             |.|...|.:           :..|...:|....|  .||::   ||..|||.:|.::|.:|...
Mouse   113 -WQDESECSE-----------NHSFKQNVDHYHHTLLSTLQLMYTVGYSLSLISLFLALTLFLFL 165

  Fly   335 RSLRNNRTKIHKNLFVAMVLQVIIRL----TLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYV 395
            |.|...|..||.|||.:.:|:.::.|    ..|....||.:.|:...:.||.|..:   |.:..|
Mouse   166 RKLHCTRNYIHMNLFASFILRALVVLVKDMVFYNSYSRRPDSESGWMSYLSEISAS---CRSVQV 227

  Fly   396 LLEYARTAMFMWMFIEGLYLHNMV--TVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDT 458
            ||.|......:|:.:||||||.::  ||...:..:| |:.. :||..|:|....|     :::..
Mouse   228 LLHYFVGTNHLWLLVEGLYLHALLEPTVLPERRLWP-KYLV-VGWAFPMLFVIPW-----IFVRA 285

  Fly   459 SLGE--CLWNYNLT-PYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAA 520
            ||..  | |..|.. ..:||:.||.|..:.:||...:.|:::|:.|.|..|....:...:..::.
Mouse   286 SLENTGC-WAVNENKKIWWIIRGPILLCVTVNFFIFLKILKLLISKFRAHQMCFRDYKYRLAKST 349

  Fly   521 IVLLPLLGITNLLHQLAPLKTATNFA--VWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLA 583
            ::|:.|:|:...|...........|:  :..:....|:||.||.:||.|.|.:.||:|.|.|:..
Mouse   350 LLLILLMGVHEFLFTFFTDDQVQGFSRLIRLFIQLTLSSFHGFLVALQYGFASREVKAELRKTWG 414

  Fly   584 TQLSVRGHPEW----------------APKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPN 632
            ..|..|   .|                ..|:.|...||       :.:|.. ..|.....::..|
Mouse   415 RFLLAR---HWGCRACVLGKNFRFLGKCSKKLSEGDGA-------ETLQKL-QSSGVSSHLTAGN 468

  Fly   633 KRLNGRKP 640
            .|.:|.:|
Mouse   469 LRDHGAQP 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	18/60 (30%)
		7tmB1_PDFR	306..584	CDD:320389	85/293 (29%)
		TM helix 1	308..333	CDD:320389	11/29 (38%)
		TM helix 2	342..364	CDD:320389	7/25 (28%)
		TM helix 3	391..418	CDD:320389	11/26 (42%)
		TM helix 4	430..450	CDD:320389	6/19 (32%)
		TM helix 5	469..498	CDD:320389	8/29 (28%)
		TM helix 6	512..539	CDD:320389	4/26 (15%)
		TM helix 7	546..571	CDD:320389	9/26 (35%)
Glp2r	NP_783612.2	HRM	53..122	CDD:397086	21/84 (25%)
		7tmB1_GLP2R	137..415	CDD:320394	84/288 (29%)
		TM helix 1	139..164	CDD:320394	10/24 (42%)
		TM helix 2	173..195	CDD:320394	7/21 (33%)
		TM helix 3	223..250	CDD:320394	11/26 (42%)
		TM helix 4	262..282	CDD:320394	7/26 (27%)
		TM helix 5	298..327	CDD:320394	8/28 (29%)
		TM helix 6	341..368	CDD:320394	4/26 (15%)
		TM helix 7	377..402	CDD:320394	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..494		5/19 (26%)