Protein Alignment Pdfr and ADGRG1

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_005256294.1
• Gene: ADGRG1 / 9289
• HGNCID: 4512
• Length: 698
• Species: Homo sapiens
• Alignment Length: 702
• Identity: 155/702 - (22%)
• Similarity: 240/702 - (34%)
• Gaps: 232/702 - (33%)

  Fly    55 RHADSLHIYYAVDGKMTLL-----SNILDCGGCISAQRFT-----RLLRQSGSSGPSP---SAPT 106
            |||..||:.|   ||...|     |::|    |...|..:     .||..|.:|..||   |.|:
Human   101 RHAGRLHLLY---GKRDFLLSDKASSLL----CFQHQEESLAQGPPLLATSVTSWWSPQNISLPS 158

  Fly   107 AGTFESKSMLEP-TSSHSLATGRVPLLHDFD-----------ASTTES--PGTYVLDGV-ARVAQ 156
            |.:|.......| |::|:.:.....|..|..           ||...|  |.:..|..: :::..
Human   159 AASFTFSFHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTS 223

  Fly   157 L-------------------ALEPT------------------VMD---ALPDSDTEQVLGNLNS 181
            :                   .|:||                  :|:   .||.:..::..|. :.
Human   224 VRFMGDMVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLFQRTKGR-SG 287

  Fly   182 SAPWNLTL---ASAAATNFENCSALFVNYTL---PQTGLYCNWTWDTLLCWPPTPAGVLARMNCP 240
            .|...|.|   :|.|....:|.|.:.....|   .|.....|.|...:|.:.
Human   288 EAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQ------------- 339

  Fly   241 GGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQ------------ 293
               |.:..:...: :|..   |...|  |..:|..|:..| |   |.:|...|
Human   340 ---HQLQPKNVTL-QCVF---WVEDP--TLSSPGHWSSAG-C---ETVRRETQTSCFCNHLTYFA 391

  Fly   294 ---MGSKDFDA----YIDIARRTRTLEIVGLCLSLFALIVSLLIF-CT------FRSLRNNRTKI 344
               :.|.:.||    |:.:      |..||..:|..|.:|::..: |:      .|..|:...|:
Human   392 VLMVSSVEVDAVHKHYLSL------LSYVGCVVSALACLVTIAAYLCSRVPLPCRRKPRDYTIKV 450

  Fly   345 HKNLFVAMVLQVIIRLTLYLD-QFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWM 408
            |.||.:|:.|         || .|......|.|.:...        |.||.:.|.::......||
Human   451 HMNLLLAVFL---------LDTSFLLSEPVALTGSEAG--------CRASAIFLHFSLLTCLSWM 498

  Fly   409 FIEGLYLHNMVTVAVFQGSFP--LKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTP 471
            .:||..|:.:| |.||....|  |...|.:||..||.:.|:.|...|    .:.|..:...:.||
Human   499 GLEGYNLYRLV-VEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDV----DNYGPIILAVHRTP 558

  Fly   472 -------YYWILE---------GPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAA 520
                   ..||.:         |....|.|.|...|..:: |.:::||       ..|:|...
Human   559 EGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMV-VQILRLR-------PHTQKWSH-- 613

  Fly   521 IVLLPLLGITNLLHQLAPLKTATNFAVWSYGT---------HFLTSFQGFFIALIYCFLNGEVRA 576
              :|.|||::.:|    .|..|..|..::.||         ..:||||||.|.:.|
Human   614 --VLTLLGLSLVL----GLPWALIFFSFASGTFQLVVLYLFSIITSFQGFLIFIWY--------- 663

  Fly   577 VLLKSLATQLSVRGHPEWAPKRASMYSGAYNTAPDTDAVQPAGDPSATGKRI 628
                 .:.:|..||.|  :|.:::..|          |..|....|.:..||
Human   664 -----WSMRLQARGGP--SPLKSNSDS----------ARLPISSGSTSSSRI 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	8/58 (14%)
		7tmB1_PDFR	306..584	CDD:320389	76/312 (24%)
		TM helix 1	308..333	CDD:320389	6/25 (24%)
		TM helix 2	342..364	CDD:320389	6/21 (29%)
		TM helix 3	391..418	CDD:320389	8/26 (31%)
		TM helix 4	430..450	CDD:320389	7/19 (37%)
		TM helix 5	469..498	CDD:320389	9/44 (20%)
		TM helix 6	512..539	CDD:320389	7/26 (27%)
		TM helix 7	546..571	CDD:320389	10/33 (30%)
ADGRG1	XP_005256294.1	PLL	34..167	CDD:436599	23/72 (32%)
		GAIN_A	178..225	CDD:436625	7/46 (15%)
		GPS	350..393	CDD:460350	11/51 (22%)
		7tm_GPCRs	405..679	CDD:475119	82/333 (25%)
		TM helix 1	408..432	CDD:320661	6/29 (21%)
		TM helix 2	448..469	CDD:320661	9/29 (31%)
		TM helix 3	481..503	CDD:320661	6/21 (29%)
		TM helix 4	523..539	CDD:320661	6/15 (40%)
		TM helix 5	572..595	CDD:320661	4/22 (18%)
		TM helix 6	614..636	CDD:320661	8/25 (32%)
		TM helix 7	642..667	CDD:320661	8/38 (21%)