DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and Sctr

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_038947043.1	Gene:	Sctr / 81779	RGDID:	621342	Length:	464	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	122/479 - (25%)
Similarity:	219/479 - (45%)	Gaps:	70/479 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 DTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVNYTLPQTGLY--CNWTWDTLLCWPPTPAGV 233
            |..:||....:.....|:.....|...|..||...:.......:|  |...||.:.|||.:....
  Rat    34 DVRRVLLEERAHCLQQLSKEKKGALGPETASASVFSPFASSHAVYQGCEGLWDNMSCWPSSAPAR 98

  Fly   234 LARMNCPGGFHGVDTRKFAIRKCELDGRWGSR-PNATEVNPPGWTDYGPCYKPEI---IRLMQQM 294
            ...:.||         ||.:.   |..:.||. .|.|:   .||::..|  :|::   :.:....
  Rat    99 TVEVQCP---------KFLLM---LSNKNGSLFRNCTQ---DGWSETFP--RPDLACGVNINNSF 146

  Fly   295 GSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIR 359
            ..:. .||:   .:.:.:..||...||..|:|:|.|.|:||.|...|..||.:|||:.:|:.:..
  Rat   147 NERR-HAYL---LKLKVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSN 207

  Fly   360 LTLYLDQFRRGNKEAATNTSLSVIENTPYL------CEASYVLLEYARTAMFMWMFIEGLYLHNM 418
            ..          |:|...:|    ::..|.      |:...:..:|...|.:.|:.:||||||.:
  Rat   208 FI----------KDAVLFSS----DDVTYCDAHKVGCKLVMIFFQYCIMANYAWLLVEGLYLHTL 258

  Fly   419 VTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNL-TPYYWILEGPRLA 482
            :.::.|.....|:.|..|||..|.:...:|| .|..:::.:  .| |:.|. ...:|::.||.:.
  Rat   259 LAISFFSERKYLQAFVLLGWGSPAIFVALWA-ITRHFLENT--GC-WDINANASVWWVIRGPVIL 319

  Fly   483 VILLNFCFLVNIIRVLVMKLR--QSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAP---LKTA 542
            .||:||.|.:||:|:|:.|||  :::.|:....::..::.::|:||.||..::...:|   ::..
  Rat   320 SILINFIFFINILRILMRKLRTQETRGSETNHYKRLAKSTLLLIPLFGIHYIVFAFSPEDAMEVQ 384

  Fly   543 TNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMYSGAYN 607
            ..|.:      .|.||||..:|::||||||||:..:.|...     :.|.:..|.|...::.:::
  Rat   385 LFFEL------ALGSFQGLVVAVLYCFLNGEVQLEVQKKWR-----QWHLQEFPLRPVAFNNSFS 438

  Fly   608 TAPD--TDAVQPAGDPSATGKRIS 629
            .|.:  |.:.:.:.:.|.:..|.|
  Rat   439 NATNGPTHSTKASTEQSRSIPRAS 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	16/61 (26%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	74/268 (28%)
Sctr	XP_038947043.1	HormR	80..147	CDD:214468	19/83 (23%)
		7tmB1_secretin	154..420	CDD:320403	84/297 (28%)
		TM helix 1	157..181	CDD:320403	8/23 (35%)
		TM helix 2	190..211	CDD:320403	6/30 (20%)
		TM helix 3	231..253	CDD:320403	4/21 (19%)
		TM helix 4	272..288	CDD:320403	5/15 (33%)
		TM helix 5	306..329	CDD:320403	8/22 (36%)
		TM helix 6	356..378	CDD:320403	5/21 (24%)
		TM helix 7	382..407	CDD:320403	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920