Protein Alignment Pdfr and ghrhrb

DIOPT Version :9

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_021333028.1
• Gene: ghrhrb / 792410
• ZFINID: ZDB-GENE-110127-2
• Length: 529
• Species: Danio rerio
• Alignment Length: 546
• Identity: 129/546 - (23%)
• Similarity: 222/546 - (40%)
• Gaps: 94/546 - (17%)

  Fly    95 SGSSGPSPSAPTAGT----------FESKSMLEPTSSHSLATGRVPLLHDFDASTTE-------- 141
            |...||....|..|.          ..::.:||  :...|......|:|.|.|...|
Zfish    10 SQQEGPIDQPPARGLSHRQNHRPFGIYAEDLLE--AVRGLGFSETTLIHIFLAGLDEPFDWEELG 72

  Fly   142 SPGTYVLDGVARVAQLALEPTVMDALPDSDTEQVLGNLNSSAPWNLTLAS------AAATNFENC 200
            ...|:....|...:.|.:|..:::......|...: :.:.|:|..||...      .|::...:|
Zfish    73 DIRTWTFWEVVDYSCLRMEREILEGEWTPLTTSTI-SWSMSSPQGLTRTQKRRRKRKASSARHHC 136

  Fly   201 SALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSR 265
            .||        .|  |...||...||.....|.:..::|...........|..|.|..|
Zfish   137 KAL--------RG--CPTEWDEFWCWSGAEVGQVVNISCSEVSQLFVNHGFIFRNCTKD------ 185

  Fly   266 PNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLI 330
                     |||:..|.|: ....:::.:.|:....|....|:..|   .|...||.:||.::.:
Zfish   186 ---------GWTEVYPSYE-NACEIVEDVESETETTYYATFRQVYT---AGYATSLISLITAIFV 237

  Fly   331 FCTFRSLRNNRTKIHKNLFVAMVLQ---VIIR-LTLYLDQFRRGNKEAATNTSLSVIENTPYLCE 391
            |..||.....|..||.|||.:.:|:   :.|: ..|:.|:          |.....:..|.  |:
Zfish   238 FTVFRKFHCTRNYIHINLFASFILRASAIFIKDAVLFADE----------NLDHCFMSTTS--CK 290

  Fly   392 ASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYM 456
            |:....:::..|.:.|:.:||:||..::.:..........::..:||.:|.|:.|:|......:.
Zfish   291 AAVAFFQFSILANYFWLLVEGMYLQTLLALTFVSQKKYFWWYILIGWGLPTLILTIWVLARNFFD 355

  Fly   457 DTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQ--SQASDIEQTRKAVRA 519
            :..   |..:.::..::||::||....:|:||...:|:||:||.||:.  ....|.....:..::
Zfish   356 NNG---CWDDTDVAYFWWIIKGPITVSLLINFLIFINVIRILVQKLKSPGMGGGDTNHFMRLAKS 417

  Fly   520 AIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTHFLT----SFQGFFIALIYCFLNGEVRAVLLK 580
            .:.|:||.|:..::....|..|..|      ..|||.    .||||.:||:||||||||:|.|.|
Zfish   418 TLFLIPLFGMHYMVFAFLPENTGEN------ARHFLELGLGPFQGFVVALLYCFLNGEVQAELKK 476

  Fly   581 SL---ATQLSVRGHPEWAPKRASMYS 603
            .|   .||..:|    ::.:|.::::
Zfish   477 RLWKWQTQSYLR----YSKRRRTLFT 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	12/58 (21%)
		7tm_4	306..563	CDD:304433	66/266 (25%)
ghrhrb	XP_021333028.1	HRM	141..199	CDD:308439	17/75 (23%)
		7tmB1_GHRHR2	213..480	CDD:320399	80/290 (28%)
		TM helix 1	215..240	CDD:320399	8/27 (30%)
		TM helix 2	249..271	CDD:320399	7/21 (33%)
		TM helix 3	290..317	CDD:320399	7/26 (27%)
		TM helix 4	329..349	CDD:320399	6/19 (32%)
		TM helix 5	364..394	CDD:320399	10/29 (34%)
		TM helix 6	410..437	CDD:320399	4/26 (15%)
		TM helix 7	442..467	CDD:320399	13/30 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020