Protein Alignment Pdfr and VIPR2

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_003373.2
• Gene: VIPR2 / 7434
• HGNCID: 12695
• Length: 438
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 105/376 - (27%)
• Similarity: 174/376 - (46%)
• Gaps: 54/376 - (14%)

  Fly   216 CNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRK-CELDGRWGSRPNATEVNPPGWTDY 279
            |:..||.:.||.|...|....:.||..|....::...|.| |..|| | |......|:..|::|
Human    52 CSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDG-W-SETFPDFVDACGYSD- 113

  Fly   280 GPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKI 344
                 ||        .......||.:    :.:..:|..:||.:|....:|.|.||.|...|..|
Human   114 -----PE--------DESKITFYILV----KAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYI 161

  Fly   345 HKNLFVAMVLQVIIRL----TLYLDQFRRGNKEAATNTSLSVIENTPYL-CEASYVLLEYARTAM 404
            |.|||::.:|:.|..|    .||          :::.|.....:.:.:: |:.|.|.|:|...|.
Human   162 HLNLFLSFILRAISVLVKDDVLY----------SSSGTLHCPDQPSSWVGCKLSLVFLQYCIMAN 216

  Fly   405 FMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYN- 468
            |.|:.:||||||.:: ||:.........:..:||.:|.:....|....:...||.   | |:.|
Human   217 FFWLLVEGLYLHTLL-VAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTG---C-WDTND 276

  Fly   469 -LTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQ--ASDIEQTRKAVRAAIVLLPLLGIT 530
             ..| :|::..|.|..|::||...::|||:|:.||....  .:|..|.::..::.::|:||.|:.
Human   277 HSVP-WWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVH 340

  Fly   531 NLLHQLAPLKTATNFAVWSYGTHF---LTSFQGFFIALIYCFLNGEVRAVL 578
            .::..:.|:..::.:.:.     |   |.||||..:|::|||||.||:..|
Human   341 YMVFAVFPISISSKYQIL-----FELCLGSFQGLVVAVLYCFLNSEVQCEL 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	17/56 (30%)
		7tmB1_PDFR	306..584	CDD:320389	81/285 (28%)
		TM helix 1	308..333	CDD:320389	5/24 (21%)
		TM helix 2	342..364	CDD:320389	9/25 (36%)
		TM helix 3	391..418	CDD:320389	13/26 (50%)
		TM helix 4	430..450	CDD:320389	4/19 (21%)
		TM helix 5	469..498	CDD:320389	10/28 (36%)
		TM helix 6	512..539	CDD:320389	5/26 (19%)
		TM helix 7	546..571	CDD:320389	10/27 (37%)
VIPR2	NP_003373.2	HormR	52..118	CDD:214468	22/81 (27%)
		7tmB1_VIP-R2	123..392	CDD:320652	83/289 (29%)
		TM helix 1	125..150	CDD:320652	5/28 (18%)
		TM helix 2	159..181	CDD:320652	8/21 (38%)
		TM helix 3	203..230	CDD:320652	13/26 (50%)
		TM helix 4	241..261	CDD:320652	4/19 (21%)
		TM helix 5	277..306	CDD:320652	10/29 (34%)
		TM helix 6	322..349	CDD:320652	5/26 (19%)
		TM helix 7	354..379	CDD:320652	10/29 (34%)