DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdfr and VIPR1

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_004615.2	Gene:	VIPR1 / 7433	HGNCID:	12694	Length:	457	Species:	Homo sapiens

Alignment Length:	492	Identity:	142/492 - (28%)
Similarity:	206/492 - (41%)	Gaps:	94/492 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 APWNLTLASA-----------AATNFENC---------------SALFVNYTLPQTGLYCNWTWD 221
            |.|...||.|           ||...|.|               .|...|.|:.     |:..||
Human     9 ARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIG-----CSKMWD 68

  Fly   222 TLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPE 286
            .|.|||.||.|.:..:.||..|     :.|:    .:.||..||....|    |||...|...|.
Human    69 NLTCWPATPRGQVVVLACPLIF-----KLFS----SIQGRNVSRSCTDE----GWTHLEPGPYPI 120

  Fly   287 IIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVA 351
            ...|..:..|.| :.........:|...:|..|||..|:|:..|...||.|...|..||.:||::
Human   121 ACGLDDKAASLD-EQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFIS 184

  Fly   352 MVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLH 416
            .:|:........|..|..|..:..:..|:.        |:|:.|..:|...|.|.|:.:|||||:
Human   185 FILRAAAVFIKDLALFDSGESDQCSEGSVG--------CKAAMVFFQYCVMANFFWLLVEGLYLY 241

  Fly   417 NMVTVAVFQGSFPLKFF---SRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEG 478
            .::.|:.|.   ..|:|   ..:||.||...|.||....:.:.|..   | |:...:..:||::|
Human   242 TLLAVSFFS---ERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYG---C-WDTINSSLWWIIKG 299

  Fly   479 PRLAVILLNFCFLVNIIRVLVMKLR--QSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAP--- 538
            |.|..||:||...:.|||:|:.|||  ..:.||.....:..|:.::|:||.|:..::....|
Human   300 PILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNF 364

  Fly   539 ---LKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRAS 600
               :|......|        .|||||.:|::||||||||:|.|.:.. .:..::|...|.||
Human   365 KPEVKMVFELVV--------GSFQGFVVAILYCFLNGEVQAELRRKW-RRWHLQGVLGWNPK--- 417

  Fly   601 MY---SGAYNTAPDTDAVQPAGDPSATGKRISPPNKR 634
             |   ||..|.|..:..|...       .|:||..:|
Human   418 -YRHPSGGSNGATCSTQVSML-------TRVSPGARR 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	19/58 (33%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	78/267 (29%)
VIPR1	NP_004615.2	HormR	59..128	CDD:214468	26/86 (30%)
VIPR1	NP_004615.2	7tm_2	139..384	CDD:278432	78/267 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920