Protein Alignment Pdfr and SCTR

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_047301355.1
• Gene: SCTR / 6344
• HGNCID: 10608
• Length: 450
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 108/387 - (27%)
• Similarity: 175/387 - (45%)
• Gaps: 74/387 - (19%)

  Fly   216 CNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAI-RKCELDGRWGS---RPN-ATEVNPPG 275
            |...||.:.|||.:..|.:..:.||.....:.:|..:: |.|..|| |..   ||| |..||
Human    66 CEGMWDNISCWPSSVPGRMVEVECPRFLRMLTSRNGSLFRNCTQDG-WSETFPRPNLACGVN--- 126

  Fly   276 WTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNN 340
                           :....::...:|:   .:.:.:..||...||..|:|:|.|.|.||.|...
Human   127 ---------------VNDSSNEKRHSYL---LKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCT 173

  Fly   341 RTKIHKNLFVAMVLQVIIRL-----------TLYLDQFRRGNKEAATNTSLSVIENTPYLCEASY 394
            |..||.:|||:.:|:.:...           ..|.|..|.|                   |:...
Human   174 RNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAG-------------------CKLVM 219

  Fly   395 VLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDT- 458
            ||.:|...|.:.|:.:||||||.::.::.|.....|:.|...||..|.:...:||.......|.
Human   220 VLFQYCIMANYSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHFLEDVG 284

  Fly   459 --SLGECLWNYNL-TPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLR--QSQASDIEQTRKAVR 518
              || .| |:.|. ...:||:.||.:..||:||...:||:|:|:.|||  :::.:::...::..|
Human   285 CPSL-RC-WDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEVSHYKRLAR 347

  Fly   519 AAIVLLPLLGITNLLHQLAP---LKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAV 577
            :.::|:||.||..::...:|   ::....|.:      .|.||||..:|::||||||||.::
Human   348 STLLLIPLFGIHYIVFAFSPEDAMEIQLFFEL------ALGSFQGLVVAVLYCFLNGEVSSL 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	19/60 (32%)
		7tmB1_PDFR	306..584	CDD:320389	86/292 (29%)
		TM helix 1	308..333	CDD:320389	8/24 (33%)
		TM helix 2	342..364	CDD:320389	6/32 (19%)
		TM helix 3	391..418	CDD:320389	11/26 (42%)
		TM helix 4	430..450	CDD:320389	6/19 (32%)
		TM helix 5	469..498	CDD:320389	11/29 (38%)
		TM helix 6	512..539	CDD:320389	7/29 (24%)
		TM helix 7	546..571	CDD:320389	9/24 (38%)
SCTR	XP_047301355.1	HRM	64..126	CDD:397086	19/60 (32%)
		7tmB1_secretin	139..400	CDD:320403	84/290 (29%)
		TM helix 1	141..166	CDD:320403	8/24 (33%)
		TM helix 2	175..197	CDD:320403	6/21 (29%)
		TM helix 3	216..243	CDD:320403	11/26 (42%)
		TM helix 4	255..275	CDD:320403	6/19 (32%)
		TM helix 5	296..325	CDD:320403	11/28 (39%)
		TM helix 6	341..368	CDD:320403	6/26 (23%)
		TM helix 7	372..397	CDD:320403	10/30 (33%)