DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and Glp2r

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_068620.1	Gene:	Glp2r / 60432	RGDID:	620270	Length:	550	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	138/519 - (26%)
Similarity:	213/519 - (41%)	Gaps:	94/519 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PSPSAPTAGTFESKSMLEPTSSHSL-------ATGRVPLLHDFDASTTESPGTYVLDGVARVAQL 157
            |||:.|      |:....|......       |.|.|| ||.........||...|      |.|
  Rat     5 PSPAVP------SRCREAPVPRVRAQPVGIPEAQGPVP-LHSQQMRLLWGPGRPFL------ALL 56

  Fly   158 ALEPTVMDALPDSDTEQVLGNL--NSSAPWNLTLASAAATNFENCSALFVNYTLPQTGLYCNWTW 220
            .|          ...:||.|:|  .::..|        |...|.|.....|..   :|::||.|:
  Rat    57 LL----------VSIKQVTGSLLKETTQKW--------ANYKEKCLEDLHNRL---SGIFCNGTF 100

  Fly   221 DTLLCWPPTPAGVLARMNCPG--GFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCY 283
            |..:|||.:..|.:: :.||.  .:...::...|.|.|...|.|.:|.|.|::    |.|...|.
  Rat   101 DRYVCWPHSYPGNVS-VPCPSYLPWWNAESPGRAYRHCLAQGTWQTRENTTDI----WQDESECS 160

  Fly   284 KPEIIRLMQQMGSKDFDAYIDIARRTRTLEI---VGLCLSLFALIVSLLIFCTFRSLRNNRTKIH 345
            :           :..|...:|......||::   ||..:||.:|.::|.:|...|.|...|..||
  Rat   161 E-----------NHSFRQNVDHYALLYTLQLMYTVGYSVSLISLFLALTLFLFLRKLHCTRNYIH 214

  Fly   346 KNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTS-----------LSVIENTPYLCEASYVLLEY 399
            .|||.:.:|:|:..|.          |:..::.|           :|.:..|...|.:..|||.|
  Rat   215 MNLFASFILKVLAVLV----------KDMVSHNSYSKRPDDESGWMSYLSETSVSCRSVQVLLHY 269

  Fly   400 ARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECL 464
            ......:|:.:||||||.::...||........:..:||..|:|....|........:|   .|
  Rat   270 FVGTNHLWLLVEGLYLHTLLEPTVFPERRLWPKYLVVGWAFPMLFVIPWGFARAHLENT---RC- 330

  Fly   465 W--NYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLL 527
            |  |.|| ..:||:.||.|..:.:||...:.|:::|:.||:..|....:...:..::.::|:|||
  Rat   331 WATNGNL-KIWWIIRGPMLLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLLLIPLL 394

  Fly   528 GITNLLHQLAPLKTATNFA--VWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVR 589
            |:..:|....|......|:  :..:....|:|..||.:||.|.|.||||:|.|.||....|..|
  Rat   395 GVHEVLFTFFPDDQVQGFSKRIRLFIQLTLSSVHGFLVALQYGFANGEVKAELRKSWGRFLLAR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	19/60 (32%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	73/274 (27%)
Glp2r	NP_068620.1	HRM	93..162	CDD:280888	22/84 (26%)
Glp2r	NP_068620.1	7tm_2	175..432	CDD:278432	73/271 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920