Protein Alignment Pdfr and pth2rb

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_017208978.2
• Gene: pth2rb / 564876
• ZFINID: ZDB-GENE-050208-334
• Length: 600
• Species: Danio rerio
• Alignment Length: 534
• Identity: 146/534 - (27%)
• Similarity: 228/534 - (42%)
• Gaps: 84/534 - (15%)

  Fly   216 CNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYG 280
            |:..||.|:|||....|.:.::.||...:..:...||.|:|..:|.|.|..|.|      |.:|.
Zfish    59 CSPGWDGLVCWPQGSPGTVTKVPCPSYVYDFNHNGFAYRQCSSNGSWVSVENRT------WVNYS 117

  Fly   281 PCYK---PEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRT 342
            .|.:   |.|     :.|.:||      ..|...:..||..:|..:|:|::.|...||.|...|.
Zfish   118 DCLRFLAPGI-----EKGKRDF------FERLHIMYTVGYAVSFSSLLVAIFIIGYFRRLHCTRN 171

  Fly   343 KIHKNLFVAMVLQVI--------IRLTLYLDQFRRGNKEAATNTSLSVIENTPYL-CEASYVLLE 398
            .||.:|||:.:|:.|        :.....|.::.....:..:..|:|.::.|.|. |:.:.:...
Zfish   172 YIHMHLFVSFMLRAISIFVKDRVVYANGVLQEYDTMLMDNISTVSISPLDKTQYFGCKITVLFFI 236

  Fly   399 YARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGEC 463
            |.....:.|:.:||||||:::.:|.|..|..|..|:.:||.||.|..:.||.......|   ..|
Zfish   237 YFLATNYYWILVEGLYLHSLIFMAFFSDSKYLWGFTLIGWGVPALFVSTWAVVRATLAD---ARC 298

  Fly   464 LWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIE---QTRKAVRAAIVLLP 525
             |..:.....||.:.|.|..|.|||...|||:|||..|:|::.|...:   |.||..::.:||:.
Zfish   299 -WELSAGNIKWIYQVPILTAIGLNFILFVNIVRVLATKIRETNAGRYDTRKQYRKLAKSTLVLVL 362

  Fly   526 LLGITNLLHQLAP-LKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKS-LATQLSV 588
            :.|:..::....| ..|...:.:..|...|..||||||:::||||.||||:|.:.|: |...|:.
Zfish   363 VFGVHYIVFVGMPHTFTGLGWELRMYCELFFNSFQGFFVSIIYCFCNGEVQAEIRKTWLRWTLAF 427

  Fly   589 RGHPEW-APKRASMY--------SGAYNTAPDTDAVQPAGDPSATGKRISPPNKRLNGRKPSSAS 644
                :| .|...:.|        |||.|.:..|...:.:   :....||.....|     ||..|
Zfish   428 ----DWKGPVVLANYRYGSVLNNSGASNQSQLTSVTRSS---ALLTSRIYRCTSR-----PSVGS 480

  Fly   645 IV-----------MIHEPQQRQRLMPRLQNKAREKGKDRVEKTDAEAEPDPTISHIHSKEAGSAR 698
            :.           .:......:.|.|.:..:..|:.|.              |..|..||.....
Zfish   481 LTHTSHIHTSLPGYVFSNSDIESLPPSIPEELEEEAKH--------------IDDITLKENAKIA 531

  Fly   699 SRTRGSKWIMGICF 712
            |.....:..:||||
Zfish   532 SAVTVRQEALGICF 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	19/55 (35%)
		7tmB1_PDFR	306..584	CDD:320389	91/291 (31%)
		TM helix 1	308..333	CDD:320389	7/24 (29%)
		TM helix 2	342..364	CDD:320389	7/29 (24%)
		TM helix 3	391..418	CDD:320389	8/26 (31%)
		TM helix 4	430..450	CDD:320389	8/19 (42%)
		TM helix 5	469..498	CDD:320389	12/28 (43%)
		TM helix 6	512..539	CDD:320389	7/27 (26%)
		TM helix 7	546..571	CDD:320389	12/24 (50%)
pth2rb	XP_017208978.2	HRM	57..119	CDD:397086	21/65 (32%)
		7tmB1_PTHR	135..422	CDD:320393	90/290 (31%)
		TM helix 1	137..162	CDD:320393	7/24 (29%)
		TM helix 2	171..193	CDD:320393	7/21 (33%)
		TM helix 3	229..256	CDD:320393	8/26 (31%)
		TM helix 4	268..288	CDD:320393	8/19 (42%)
		TM helix 5	303..332	CDD:320393	12/28 (43%)
		TM helix 6	349..376	CDD:320393	6/26 (23%)
		TM helix 7	384..409	CDD:320393	12/24 (50%)