Protein Alignment Pdfr and gcgra

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_691434.5
• Gene: gcgra / 562973
• ZFINID: ZDB-GENE-050516-1
• Length: 520
• Species: Danio rerio
• Alignment Length: 483
• Identity: 132/483 - (27%)
• Similarity: 211/483 - (43%)
• Gaps: 87/483 - (18%)

  Fly   210 PQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGF-------HGVDTRKFAIRKCELDGRWGSRPN 267
            |.||:.||.|:|...|||.........:.||...       ||:     ...:|:.||::..:.:
Zfish    48 PMTGVVCNRTFDRYACWPDALPNTTVSVACPWYLPWHKEVRHGL-----VHVECDADGQYSKQKD 107

  Fly   268 ATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFC 332
            |:|           |           :...:...|..|.|:.||:..||..|||.||:::|.|..
Zfish   108 ASE-----------C-----------LSRDNIQHYGRILRQFRTMYTVGYSLSLGALVLALSILV 150

  Fly   333 TFRSLRNNRTKIHKNLFVAMVLQ---VIIR--LTLYLDQFRRGNKEAATNTSLSV---IEN-TPY 388
            .||.|...|..||.|||.:.:|:   ::|:  |:...|.|..|..   ..|.|.|   ::| |..
Zfish   151 AFRKLHCMRNNIHMNLFASFILRASSILIKDALSERPDTFPVGQD---ITTELEVEWLVKNETAV 212

  Fly   389 LCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTV 453
            .|..:.|:::|:..|...|:.:||:|||:::.|.|......|..:..:||..|::....|.....
Zfish   213 GCRVAVVMMQYSILANSYWLLVEGIYLHSLLVVTVLTERNYLSIYLSIGWGAPLIFVLPWVIVKY 277

  Fly   454 MYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVR 518
            :|.:.   ||....|...|:||:..|.|..:|:||...::||::||.|||..|....:...:..:
Zfish   278 LYENE---ECWEQNNHMEYWWIIRSPILLAVLINFFIFIHIIKILVSKLRAHQMRYSDYKFRLAK 339

  Fly   519 AAIVLLPLLGITNLL----------HQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGE 573
            :.:.|:|||||.::|          |...||:....|.     ..|..||||..:|::|||:|.|
Zfish   340 STLTLIPLLGIHSVLFSFVTDESTSHGALPLRLTKLFI-----DLFFNSFQGLLVAILYCFVNKE 399

  Fly   574 VRAVLLKSLATQLSVRGHPEWAPKR--ASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPNKRLN 636
            |::.:||...         .|...|  ...|...|:.:..   :|.:|     ...:.|.|.
Zfish   400 VQSEILKKWR---------RWKLGRDIEEEYRHTYSQSLQ---IQKSG-----SIMVHPTNL--- 444

  Fly   637 GRKPSSASIV-MIHEPQQRQRLMPRLQN 663
            .|.|..|:.. .:..|:::|.|:...||
Zfish   445 PRLPDIATTTSRLGSPEEKQMLVSSSQN 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	17/65 (26%)
		7tmB1_PDFR	306..584	CDD:320389	94/296 (32%)
		TM helix 1	308..333	CDD:320389	11/24 (46%)
		TM helix 2	342..364	CDD:320389	8/26 (31%)
		TM helix 3	391..418	CDD:320389	9/26 (35%)
		TM helix 4	430..450	CDD:320389	5/19 (26%)
		TM helix 5	469..498	CDD:320389	10/28 (36%)
		TM helix 6	512..539	CDD:320389	8/36 (22%)
		TM helix 7	546..571	CDD:320389	9/24 (38%)
gcgra	XP_691434.5	HRM	51..113	CDD:397086	18/88 (20%)
		7tmB1_GlucagonR-like	124..410	CDD:341353	94/305 (31%)
		TM helix 1	126..151	CDD:341353	11/24 (46%)
		TM helix 2	160..182	CDD:341353	7/21 (33%)
		TM helix 3	215..242	CDD:341353	9/26 (35%)
		TM helix 4	254..274	CDD:341353	5/19 (26%)
		TM helix 5	290..319	CDD:341353	10/28 (36%)
		TM helix 6	333..360	CDD:341353	7/26 (27%)
		TM helix 7	372..397	CDD:341353	10/29 (34%)