DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and calcr

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_003200679.2	Gene:	calcr / 560268	ZFINID:	ZDB-GENE-060503-420	Length:	598	Species:	Danio rerio

Alignment Length:	675	Identity:	175/675 - (25%)
Similarity:	278/675 - (41%)	Gaps:	140/675 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SETKTKTEAEIEIE-----MERDQFSIAAN--ACMSMGPMLISKDKAP------CSGGRVRHADS 59
            :|||....|::.:.     |||::..:..:  .|:.    |:|:|.:.      ||    |..|.
Zfish    23 TETKADPGADLSLSPVMMAMERERLIMTQSQYKCLE----LLSRDGSHNKTGSFCS----RFWDG 79

  Fly    60 LHIYYAVDGKMTLLSNILDCGGCISAQRFTRLLRQSGSSGPSPSAPTAGTFESKSMLEPTSSHSL 124
            |..:...........|..|.......::.|:...:||:...|.|            :..|.||.|
Zfish    80 LLCWDETPAGTFASQNCPDYPSFDPLEKVTKYCDESGNWVHSAS------------INKTWSHCL 132

  Fly   125 ATGRVPL----LHDFDASTTESPGTYVLDGVARVAQLALEPTVMDALPD-----SDTEQVLGNLN 180
            ...:..:    :|.|..:.||...|         |:..:.|.|:....:     ....:....:|
Zfish   133 TFSKDKIKTLPVHGFSETETELDPT---------AESKVSPVVIQKAEERKMIIDGQYKCFEKMN 188

  Fly   181 SSAPWNLTLASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHG 245
            ...|:|                        ::|||||.|||..|||..||||......||..|..
Zfish   189 RDQPYN------------------------KSGLYCNRTWDGWLCWDDTPAGTFTSQYCPNYFAD 229

  Fly   246 VDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTR 310
            .|:.:...:.|:..|.|...|.....    |::|..|......:|..        |||     ..
Zfish   230 FDSTEKVTKYCDETGNWFRHPETNRT----WSNYTLCIAHTKDKLKM--------AYI-----LY 277

  Fly   311 TLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQ---VIIRLTLYLDQFRRGNK 372
            .:.|||..||:.:|::||.||..||||...|..:|||||.:.||.   .|:.|...::
Zfish   278 YMAIVGHALSIVSLLISLAIFFYFRSLSCQRITLHKNLFCSYVLNSAFTIVNLITVVN------- 335

  Fly   373 EAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLG 437
                  :..|::..|..|:..:....|.....:.||..||:|||.::.||||.....|.::..||
Zfish   336 ------NPKVVQRNPISCKVLHFFHMYMLGCNYFWMLCEGIYLHTLIVVAVFAEEQHLHWYYLLG 394

  Fly   438 WCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKL 502
            |..|::..::.|.....|.|.:   | |....|...:::.||.:|.:|:|..||:||:||||.||
Zfish   395 WGFPLVPASIHAVARKKYFDDN---C-WMSVETHLLYVVHGPIMAALLVNLFFLLNIVRVLVTKL 455

  Fly   503 RQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTATNFA--VWSYGTHFLTSFQGFFIAL 565
            |.:..::.....|||||.::|:|||||..:   :.|.:.....|  ::.|..|.|..:||..:|.
Zfish   456 RDTHRAESNMYMKAVRATLILVPLLGIQFV---IIPWRPENRLAGEIYDYIMHILMHYQGLLVAT 517

  Fly   566 IYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKR---ASMYSGAYNTAPDTDAVQPA----GDPSA 623
            |:||.||||:..|.:..     ::...:|..:|   .||.|.:|.....|:.  ||    .|.:
Zfish   518 IFCFFNGEVQGALKRQW-----MQYKAQWGQRRREHCSMRSTSYTATSITEV--PAFMFHHDCN- 574

  Fly   624 TGKRISPPNKRLNGRKPSSASIVMI 648
                    ::.|||::...:.:|.:
Zfish   575 --------SEHLNGKQTEDSELVAL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	23/58 (40%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	84/261 (32%)
calcr	XP_003200679.2	HRM	70..>120	CDD:308439	10/53 (19%)
		HRM	197..265	CDD:308439	26/71 (37%)
		7tmB1_calcitonin_R	273..536	CDD:320402	96/292 (33%)
		TM helix 1	275..300	CDD:320402	11/29 (38%)
		TM helix 2	309..331	CDD:320402	8/21 (38%)
		TM helix 3	348..375	CDD:320402	8/26 (31%)
		TM helix 4	387..407	CDD:320402	5/19 (26%)
		TM helix 5	422..451	CDD:320402	11/28 (39%)
		TM helix 6	465..492	CDD:320402	12/29 (41%)
		TM helix 7	498..523	CDD:320402	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840