DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdfr and adcyap1r1b

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_021327469.1	Gene:	adcyap1r1b / 555473	ZFINID:	ZDB-GENE-110127-1	Length:	445	Species:	Danio rerio

Alignment Length:	416	Identity:	122/416 - (29%)
Similarity:	194/416 - (46%)	Gaps:	55/416 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 ENC-SALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGR 261
            |.| ..:|::....:..|.|.|.||.|.||.|...|.:..|.||..|..::.......|.
Zfish    35 EKCIERMFLDDPNSEPELVCRWMWDNLTCWQPARLGQVVWMPCPELFEVMNDENNEFGKV----- 94

  Fly   262 WGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIV 326
              || |.||.   ||::..|.|..  :....:.|:.....|:.:    :.|..||...||.:|..
Zfish    95 --SR-NCTEY---GWSEMVPHYVD--VCPFNENGTNPDMYYVSV----KALYTVGYSTSLVSLTT 147

  Fly   327 SLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCE 391
            :::|.|.||.|...|..||.||||:.:|:.|   ::::.......:|.:.:..:..:|     |:
Zfish   148 AMVILCKFRKLHCTRNFIHMNLFVSFILRAI---SVFIKDGILYAEEDSNHCFIHTVE-----CK 204

  Fly   392 ASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYM 456
            |..|...|...:.:.|:|||||||..::....|.......:::.:||..|.:..|:||.....:
Zfish   205 AVMVFFHYCVLSNYFWLFIEGLYLFTLLVETFFPEKRYFYWYTIIGWGTPTICVTIWAVLRAHF- 268

  Fly   457 DTSLGECLW--NYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAV-- 517
             .::| | |  |.|.| .:|:::||.||.|::||...:.||.:||.||   |:.||.....::
Zfish   269 -DNIG-C-WDINDNAT-IWWVIKGPVLASIMINFILFIGIIIILVQKL---QSPDIGGNESSIYL 326

  Fly   518 ---RAAIVLLPLLGITNLLHQLAPLKTA-TNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVL 578
               |:.::|:||.||...:....|...: ....|:..|   |.|||||.:|::||||||||::.:
Zfish   327 RLARSTLLLIPLFGIHYTVFAFTPEDVSKRERLVFELG---LGSFQGFVVAVLYCFLNGEVQSEI 388

  Fly   579 LKS---------LATQLSVRGHPEWA 595
            .:.         .|..:..| ||..|
Zfish   389 KRKWRSWTVNRYFAVDMKHR-HPSLA 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	20/58 (34%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	79/264 (30%)
adcyap1r1b	XP_021327469.1	HRM	51..117	CDD:308439	24/78 (31%)
		7tm_GPCRs	127..394	CDD:333717	89/289 (31%)
		TM helix 1	130..154	CDD:320095	7/27 (26%)
		TM helix 2	163..184	CDD:320095	8/23 (35%)
		TM helix 3	204..226	CDD:320095	7/21 (33%)
		TM helix 4	245..261	CDD:320095	4/15 (27%)
		TM helix 5	279..302	CDD:320095	10/23 (43%)
		TM helix 6	326..351	CDD:320095	6/24 (25%)
		TM helix 7	356..381	CDD:320095	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920