DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and calcrl

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_012825895.1	Gene:	calcrl / 549647	XenbaseID:	XB-GENE-5736126	Length:	481	Species:	Xenopus tropicalis

Alignment Length:	377	Identity:	123/377 - (32%)
Similarity:	182/377 - (48%)	Gaps:	54/377 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 GLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWT 277
            |.:||.|||..|||....|||::...||..|...|..:...::|..:|.|...|::...    ||
Frog    81 GHFCNRTWDGWLCWGDVSAGVISEQRCPDYFQDFDPSEKVTKECGKNGHWFRHPDSNRT----WT 141

  Fly   278 DYGPC--YKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNN 340
            :|..|  :..|.::               .|.....|.|:|..||:.:|::||.||..|::|...
Frog   142 NYTRCNTFTHEKVK---------------TALNLYYLTIIGHGLSIASLLISLGIFFYFKNLSCQ 191

  Fly   341 RTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIEN-------TPYLCEASYVLLE 398
            |..:|||||.:.|...||                 |..|||.:.|       .|..|:.|..:..
Frog   192 RITLHKNLFFSFVCNSII-----------------TIISLSAVANNQALVATNPVSCKISQFIHL 239

  Fly   399 YARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGEC 463
            |.....:.||..||:|||.::.||||.....|.::..|||..|::...:.|....:|.:.:   |
Frog   240 YLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYLLGWGFPLIPACIHAVARSLYYNDN---C 301

  Fly   464 LWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLG 528
             |..:.|...:|:.||..|.:|:|..||:||:|||:.||:.:..::.....|||||.::|:||||
Frog   302 -WISSETHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLG 365

  Fly   529 ITNLLHQLAPLKTATNFA--VWSYGTHFLTSFQGFFIALIYCFLNGEVRAVL 578
            |..:|.   |.|.....|  ::.|..|.|..:||..:|.|:||.||||:|||
Frog   366 IEFVLF---PWKPEGRIAEEIYDYVMHILMHYQGLLVATIFCFFNGEVQAVL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	20/58 (34%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	87/265 (33%)
calcrl	XP_012825895.1	HRM	81..149	CDD:367186	24/71 (34%)
		7tmB1_calcitonin_R	157..429	CDD:341343	98/282 (35%)
		TM helix 1	159..184	CDD:341343	10/24 (42%)
		TM helix 2	193..215	CDD:341343	10/38 (26%)
		TM helix 3	232..259	CDD:341343	9/26 (35%)
		TM helix 4	271..291	CDD:341343	5/19 (26%)
		TM helix 5	306..335	CDD:341343	12/28 (43%)
		TM helix 6	349..376	CDD:341343	14/29 (48%)
		TM helix 7	382..407	CDD:341343	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940