DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and Calcrl

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_061252.2	Gene:	Calcrl / 54598	MGIID:	1926944	Length:	463	Species:	Mus musculus

Alignment Length:	482	Identity:	147/482 - (30%)
Similarity:	215/482 - (44%)	Gaps:	79/482 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 PWNLTLASAAATNFENCSALFVNYTLPQT------------------GLYCNWTWDTLLCWPPTP 230
            |.|:.|.||.:....|.:.|.|......|                  |||||.|||..|||....
Mouse    14 PLNMALISAESEEGVNQTDLGVTRNKIMTAQYECYQKIMQDPIQQAEGLYCNRTWDGWLCWNDVA 78

  Fly   231 AGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMG 295
            ||..:...||..|...|..:...:.|:.||.|...|::...    ||:|..|
Mouse    79 AGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRT----WTNYTLC------------- 126

  Fly   296 SKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRL 360
            :......:..|.....|.|:|..||:.:||:||:||..|:||...|..:|||||.:.:...|:.:
Mouse   127 NNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICNSIVTI 191

  Fly   361 TLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQ 425
             ::|..........|||         |..|:.|..:..|.....:.||..||:|||.::.||||.
Mouse   192 -IHLTAVANNQALVATN---------PVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLIVVAVFA 246

  Fly   426 GSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCF 490
            ....|.::..|||..|:|...:.|....:|.:.:   | |..:.|...:|:.||..|.:|:|..|
Mouse   247 EKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDN---C-WISSDTHLLYIIHGPICAALLVNLFF 307

  Fly   491 LVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPL-KTATNFAVWSYGTHF 554
            |:||:|||:.||:.:...:.....|||||.::|:|||||..:|....|. |.|..  |:.|..|.
Mouse   308 LLNIVRVLITKLKVTHQVESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEE--VYDYVMHI 370

  Fly   555 LTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMYSGAYNTAPDTDAVQPAG 619
            |..|||..:|.|:||.||||:|:|.::            |...:....:|..:    :||::.|
Mouse   371 LMHFQGLLVATIFCFFNGEVQAILRRN------------WNQYKIQFGNGFSH----SDALRSA- 418

  Fly   620 DPSATGKRISP--------PNKRLNGR 638
              |.|...||.        |.:.|||:
Mouse   419 --SYTVSTISDMQGYSHDCPTEHLNGK 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	22/58 (38%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	89/257 (35%)
Calcrl	NP_061252.2	HRM	61..128	CDD:397086	26/83 (31%)
		7tmB1_calcitonin_R	137..410	CDD:341343	101/300 (34%)
		TM helix 1	140..164	CDD:341343	11/23 (48%)
		TM helix 2	173..194	CDD:341343	6/21 (29%)
		TM helix 3	212..234	CDD:341343	5/21 (24%)
		TM helix 4	253..269	CDD:341343	5/15 (33%)
		TM helix 5	286..309	CDD:341343	8/22 (36%)
		TM helix 6	334..356	CDD:341343	10/21 (48%)
		TM helix 7	362..387	CDD:341343	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840