Protein Alignment Pdfr and crhr1

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001011042.1
• Gene: crhr1 / 496451
• XenbaseID: XB-GENE-966548
• Length: 503
• Species: Xenopus tropicalis
• Alignment Length: 555
• Identity: 140/555 - (25%)
• Similarity: 222/555 - (40%)
• Gaps: 126/555 - (22%)

  Fly   124 LATGRVPLLHDFDASTTESPGTYVLDGVARVAQLALEPTVMDALPDSDTEQVLGNLNSSAPWNLT 188
            |.|..:....|.|...|.....|:|....|:.|.::            |.|..|.:.:::
 Frog    15 LVTCPIKAAVDADDVITREEQIYLLSRAKRLCQTSM------------TTQATGAIRNTS----- 62

  Fly   189 LASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAI 253
                                   .||.|...||.::|||......|..::||...:..:.:.||.
 Frog    63 -----------------------KGLSCPPEWDGIICWPRGSPNELVSVSCPEHIYDFNHQGFAY 104

  Fly   254 RKCELDGRWGSRPNATEVNPPG----WTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEI 314
            |||...|.|        :..||    |.:|..|        :..:||.......::..|.|.:..
 Frog   105 RKCGQSGTW--------IQVPGLNRTWANYSEC--------LTWVGSGHRAKEKELFERLRLIYT 153

  Fly   315 VGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQ---VIIR-LTLYLDQFRRGNKEAA 375
            :|..:||.||:::|.|.|.|:.|...|..||.:||.:.:.:   :.:: ..||..:    |:.||
 Frog   154 IGYSISLAALLLALCILCYFKRLHCTRNYIHIHLFASFICRAGSIFLKDAILYSGE----NEGAA 214

  Fly   376 TNTSL--SVIENTPYL---CEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSR 435
            .:..:  .:.:.|...   |:.:..|..|.......|:.:||||||:::.:|.....   .:|..
 Frog   215 LDEKIEFGLSKRTGLQWAGCKVTVTLFLYFLATNHYWILVEGLYLHSLIFMAFLSDR---NYFWA 276

  Fly   436 L---GWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRV 497
            |   ||.:|.:..:|||...|...||   :| |:.:.....||.:.|.||..|:||...:||:||
 Frog   277 LIIIGWGLPAVFVSVWASVRVSLADT---QC-WDLSAGHMKWIYQTPILAATLVNFILFLNIVRV 337

  Fly   498 LVMKLRQS---QASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTH---FLT 556
            |..||.::   :....:|..|.:::.:||:||.|:..:|....|....|.. :|....|   |..
 Frog   338 LASKLWETNNRKQDPCQQYGKLLKSTLVLMPLFGVHYVLFMAIPYTEVTGL-LWQIQMHYEMFFN 401

  Fly   557 SFQGFFIALIYCFLNGEVR------------AVLLKSLATQLSVRGHPEW--------------- 594
            |.||||:|:||||.||||:            ||.||..:...|..|...:
 Frog   402 SSQGFFVAIIYCFCNGEVQAEARKFWFRRNLAVDLKQKSRMTSTGGSCHYGGVLTHTTNSVCLSM 466

  Fly   595 ---APKRASMYSGAY------NTAPDTDAVQPAGD 620
               ..:.||:.|.|:      ||.......|..|:
 Frog   467 VARGKQMASLQSSAHLPGYISNTVTSNSTTQQLGN 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	18/58 (31%)
		7tmB1_PDFR	306..584	CDD:320389	93/307 (30%)
		TM helix 1	308..333	CDD:320389	9/24 (38%)
		TM helix 2	342..364	CDD:320389	5/25 (20%)
		TM helix 3	391..418	CDD:320389	9/26 (35%)
		TM helix 4	430..450	CDD:320389	7/22 (32%)
		TM helix 5	469..498	CDD:320389	11/28 (39%)
		TM helix 6	512..539	CDD:320389	8/26 (31%)
		TM helix 7	546..571	CDD:320389	13/27 (48%)
crhr1	NP_001011042.1	HRM	64..129	CDD:397086	22/72 (31%)
		7tm_GPCRs	145..429	CDD:475119	89/295 (30%)
		TM helix 1	148..172	CDD:410628	8/23 (35%)
		TM helix 2	181..202	CDD:410628	4/20 (20%)
		TM helix 3	235..257	CDD:410628	4/21 (19%)
		TM helix 4	276..292	CDD:410628	4/15 (27%)
		TM helix 5	309..332	CDD:410628	8/22 (36%)
		TM helix 6	360..382	CDD:410628	6/21 (29%)
		TM helix 7	391..416	CDD:410628	12/24 (50%)