Protein Alignment Pdfr and Adgrg5

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001139444.1
• Gene: Adgrg5 / 382045
• MGIID: 2685955
• Length: 524
• Species: Mus musculus
• Alignment Length: 376
• Identity: 81/376 - (21%)
• Similarity: 147/376 - (39%)
• Gaps: 102/376 - (27%)

  Fly   259 DGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFA 323
            :|.:..:|:||:|       ...|.......::.|:......|.:.:.  ...:..||..:|:.|
Mouse   203 EGCYTEQPSATQV-------LCHCNHLTYFAVLMQLSGDPVPAELQVP--LEYISFVGCSISIVA 258

  Fly   324 LIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPY 388
            .::::|::...|...::.|:||.||..:::|   :.:|..|             :|...:...|.
Mouse   259 SLLTILLYAQSRKQSDSTTRIHMNLNGSVLL---LNVTFLL-------------SSQMTLPTMPR 307

  Fly   389 -LCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSR-------LGWCVPILM- 444
             :|:....:|.||..:...||.|||..|:      :|.|.....:..|       |||..|.|:
Mouse   308 PVCKVLAAVLHYALLSSLTWMAIEGFNLY------LFLGRVYNAYIRRYLLKLCMLGWGFPALLV 366

  Fly   445 -------TTVWARCTVMYMDTSLGECLWN---YNLTPYYWILEGPRLAVILL----NFCFLVNII 495
                   ::|:..|.     |||.:...|   :......|| ..|.:..||:    .|..|.|::
Mouse   367 LLLLMIKSSVYGPCV-----TSLSKSQENGTGFQNVSMCWI-RSPMVHSILVMGYGGFTSLFNLV 425

  Fly   496 RV-----LVMKLRQSQASDIEQTRKAVR------AAIVLLPLLGITNLLHQLAPLKTATNFAVWS 549
            .:     ::.:||..:        ||:.      .|:|    ||:|.|      |.|....|.:|
Mouse   426 VLAWALWILCRLRARE--------KALSPWAYRDTAMV----LGLTVL------LGTTWTLAFFS 472

  Fly   550 YGTHFL---------TSFQGFFIALIYC----FLNGEVRAVLLKSLATQLS 587
            :|...|         .|..|||:.|.:|    :.:.|.:|.:....::|::
Mouse   473 FGVFLLPQLFLFTIFNSLYGFFLFLWFCSQKRYSDAEAKAEMEAVSSSQMT 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	4/12 (33%)
		7tmB1_PDFR	306..584	CDD:320389	72/324 (22%)
		TM helix 1	308..333	CDD:320389	5/24 (21%)
		TM helix 2	342..364	CDD:320389	7/21 (33%)
		TM helix 3	391..418	CDD:320389	9/26 (35%)
		TM helix 4	430..450	CDD:320389	7/34 (21%)
		TM helix 5	469..498	CDD:320389	8/37 (22%)
		TM helix 6	512..539	CDD:320389	8/32 (25%)
		TM helix 7	546..571	CDD:320389	10/37 (27%)
Adgrg5	NP_001139444.1	GPS	183..228	CDD:460350	6/31 (19%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	185..235		7/38 (18%)
		Stachel. /evidence=ECO:0000250|UniProtKB:Q8IZF4	224..232		1/7 (14%)
		7tm_GPCRs	242..514	CDD:475119	72/319 (23%)
		TM helix 1	244..268	CDD:410628	5/23 (22%)
		TM helix 2	277..298	CDD:410628	8/36 (22%)
		TM helix 3	311..333	CDD:410628	7/21 (33%)
		TM helix 4	353..369	CDD:410628	5/15 (33%)
		TM helix 5	405..428	CDD:410628	6/22 (27%)
		TM helix 6	452..474	CDD:410628	10/31 (32%)
		TM helix 7	478..503	CDD:410628	7/24 (29%)