DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and Gipr

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_006540205.1	Gene:	Gipr / 381853	MGIID:	1352753	Length:	502	Species:	Mus musculus

Alignment Length:	488	Identity:	132/488 - (27%)
Similarity:	208/488 - (42%)	Gaps:	105/488 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 ENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCP---GGFHGVDTRKFAIRKCELD 259
            :.|..: :..|.|.:||.||.::|...||..|.|...||::||   ..|..| :..|..|:|..|
Mouse    40 QECQKM-LETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQV-SAGFVFRQCGSD 102

  Fly   260 GRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFAL 324
            |:|||           |.|:..|..||      :.|:  |.....|..|.:.:..||..|||..|
Mouse   103 GQWGS-----------WRDHTQCENPE------KNGA--FQDQTLILERLQIMYTVGYSLSLTTL 148

  Fly   325 IVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQ-------FRRGNKEAATNTSLSV 382
            :::|||...||.|...|..||.|||.:.:|:....||  .||       :.........|.:|:.
Mouse   149 LLALLILSLFRRLHCTRNYIHMNLFTSFMLRAAAILT--RDQLLPPLGPYTGDQAPTPWNQALAA 211

  Fly   383 IENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTV 447
                   |..:.::.:|...|.:.|:.:||:|||:::.:.........:.:..|||..|.|....
Mouse   212 -------CRTAQIMTQYCVGANYTWLLVEGVYLHHLLVIVGRSEKGHFRCYLLLGWGAPALFVIP 269

  Fly   448 WARCTVMYMDTSLGECLWNYN-LTPYYWILEGPRLAVIL-------------------------- 485
            |.  .|.|:..:. :| |..| :...:||:..|.|..||
Mouse   270 WV--IVRYLRENT-QC-WERNEVKAIWWIIRTPILITILVGPVSPPPGCTQGFLILGKRSANPLS 330

  Fly   486 ----------------LNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITNLLH 534
                            :||...:.|:.:||.|||..|....:...:..|:.:.|:||||:..::
Mouse   331 HPRNRMASGSVSLSSQINFLIFIRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVV- 394

  Fly   535 QLAP-----LKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVL--------LKSLATQL 586
             .||     ::.:..||..::.. ||:|||||.::::|||:|.||::.:        |:....:.
Mouse   395 -FAPVTEEQVEGSLRFAKLAFEI-FLSSFQGFLVSVLYCFINKEVQSEIRQGWRHRRLRLSLQEQ 457

  Fly   587 SVRGHPEWAPKRASMYSGAYNTAPDTDAVQPAG 619
            ..|.|.|.|| ||...|.|...|...:|: |:|
Mouse   458 RPRPHQELAP-RAVPLSSACREAAVGNAL-PSG 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	23/61 (38%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	78/311 (25%)
Gipr	XP_006540205.1	HRM	54..117	CDD:367186	26/74 (35%)
		7tmB1_GlucagonR-like	130..447	CDD:341353	84/332 (25%)
		TM helix 1	133..157	CDD:341353	9/23 (39%)
		TM helix 2	166..187	CDD:341353	8/22 (36%)
		TM helix 3	213..235	CDD:341353	4/21 (19%)
		TM helix 4	254..270	CDD:341353	5/15 (33%)
		TM helix 5	288..353	CDD:341353	8/64 (13%)
		TM helix 6	375..400	CDD:341353	8/26 (31%)
		TM helix 7	409..434	CDD:341353	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920