Protein Alignment Pdfr and mthl10

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 118/613 - (19%)
• Similarity: 194/613 - (31%)
• Gaps: 207/613 - (33%)

  Fly   102 PSAPTAGTFESKSMLEPTSSHSLATGRVPLLHDFDASTTES-----PGTYVLDGVARVAQLALEP 161
            |..|    |.:..|.|....|::....|| .:.:|......     .|:|...|....|:|.
  Fly    31 PGIP----FGTYVMAERDHYHTIDDPNVP-CNFYDTVNLTGHRLFPNGSYDYYGTIVPAELV--- 87

  Fly   162 TVMDALPDSDTEQV-------------LGNLNSSAPW-----------------NLTLASAAATN 196
            ...|.:..|.||::             ...||...||                 |.|.......|
  Fly    88 GTYDYIHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVFNSEVDGCIIDHSDNRTWPDPPMLN 152

  Fly   197 --FENCSALFVN----------------YTL-PQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGG 242
              |.|.|.:.||                ::| |:|.     .||..|.:   ..|.:.|::
  Fly   153 ITFRNESTILVNMFTQFAIQSFRPCPKMFSLQPETN-----NWDDYLLF---ENGSMLRVD---- 205

  Fly   243 FHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIAR 307
                  .|..|||.|.                       |..|..:. ...|......|..|:..
  Fly   206 ------DKLLIRKNEF-----------------------CMVPTYVN-ESDMFYTIHPANCDMQD 240

  Fly   308 RTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMV-LQVIIRLTLYLDQFRRGN 371
            ...|::|:.....:|::...:|....:..:...|.:..|:|...:: |.|......|:..:
  Fly   241 DHSTVKIINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLY---- 301

  Fly   372 KEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYL-HNMVTVAVFQGS-----FPL 430
            :..||..:..|...|.|          :.....:||:.:....| ||      |:|:     |..
  Fly   302 QVDATGVTCKVFGYTAY----------FFFMGAYMWLSVISFDLWHN------FRGTRGINRFQE 350

  Fly   431 K----FFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNY--NLTP------YYWI-------- 475
            |    |:|...|.:.:          |....|...:.|.|.  ||.|      |.|:
  Fly   351 KKRFLFYSLYSWGIAL----------VFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSNWAAM 405

  Fly   476 --LEGPRLAVILLN-FCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAA----------------- 520
              ..||.||:::.| ..|::..|::..::...::....|.:.|.:|..
  Fly   406 IYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRAWSNYRFGLF 470

  Fly   521 IVLLPLLGITNLLHQLAPLKTATNFAV-----WS---YGTHFLTSFQGFFIALIYCFLNGEVRAV 577
            :.|..::|||.|...:       ::.|     ||   |.:....:.|||.|.:::      |...
  Fly   471 LRLFLIMGITWLTELI-------SYFVGSDKGWSKLFYISDLANAMQGFLIFMLF------VMKK 522

  Fly   578 LLKSLATQ--LSVRGHPEWAPKRASMYS 603
            .:|.|.|.  .|||   :.:.:|.|.||
  Fly   523 KVKHLITNRCSSVR---DGSNQRQSQYS 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	10/58 (17%)
		7tmB1_PDFR	306..584	CDD:320389	62/332 (19%)
		TM helix 1	308..333	CDD:320389	4/24 (17%)
		TM helix 2	342..364	CDD:320389	4/22 (18%)
		TM helix 3	391..418	CDD:320389	4/27 (15%)
		TM helix 4	430..450	CDD:320389	4/23 (17%)
		TM helix 5	469..498	CDD:320389	11/45 (24%)
		TM helix 6	512..539	CDD:320389	7/43 (16%)
		TM helix 7	546..571	CDD:320389	8/32 (25%)
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	39/224 (17%)
		7tmB3_Methuselah-like	242..533	CDD:410632	63/333 (19%)
		TM helix 1	244..269	CDD:410632	4/24 (17%)
		TM helix 2	278..300	CDD:410632	5/21 (24%)
		TM helix 3	311..338	CDD:410632	6/36 (17%)
		TM helix 4	354..374	CDD:410632	5/29 (17%)
		TM helix 5	401..430	CDD:410632	7/28 (25%)
		TM helix 6	446..489	CDD:410632	7/49 (14%)
		TM helix 7	497..522	CDD:410632	7/30 (23%)