Protein Alignment Pdfr and Sctr

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001012322.2
• Gene: Sctr / 319229
• MGIID: 2441720
• Length: 464
• Species: Mus musculus
• Alignment Length: 462
• Identity: 122/462 - (26%)
• Similarity: 210/462 - (45%)
• Gaps: 95/462 - (20%)

  Fly   170 SDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVL 234
            |:.::.||...:||   :..:.:|.           :||:.|.   |...||.:.|||.:.....
Mouse    51 SEEKKALGPKTASA---IVFSPSAP-----------SYTVHQG---CERFWDNMSCWPSSALAQT 98

  Fly   235 ARMNCPGGFHGVDTRKFAIRKCELDGRWGSR-PNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKD 298
            ..:.||         || :|.  ..||.||. .|.|:   .||::..|  :|::...:...||
Mouse    99 VEVPCP---------KF-LRM--FSGRNGSLFRNCTK---DGWSETFP--RPDLACGVNMNGS-- 144

  Fly   299 FD----AYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIR 359
            |:    ||:   .:.:.:..||...||..|:|:|.|.|:||.|...|..||.:|||:.:|:.:..
Mouse   145 FNERRHAYL---LKLKVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSN 206

  Fly   360 L-----------TLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGL 413
            .           ..|.|..|.|                   |:...:..:|...|.:.|:.:|||
Mouse   207 FIKDAVLFPADDVTYCDAHRAG-------------------CKLVMIFFQYCIMANYAWLLVEGL 252

  Fly   414 YLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNL-TPYYWILE 477
            |||.::.::.|.....|:.|...||..|.:...:|| .|..::: ..| | |:.|. ...:|::.
Mouse   253 YLHTLLAISFFSERKCLQAFVLFGWGSPAIFVALWA-VTRHFLE-DFG-C-WDINSNASIWWVIR 313

  Fly   478 GPRLAVILLNFCFLVNIIRVLVMKLR--QSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAP-- 538
            ||.:..|::||.|.:||:|:|:.|||  :::.::....::..::.::|:||.||..::...:|
Mouse   314 GPVILSIVINFIFFINILRILMRKLRTQETRGNETHHYKRLAKSTLLLIPLFGIHYIVFAFSPEG 378

  Fly   539 -LKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMY 602
             ::....|.:      .|.||||..:|::||||||||:..:.|...     :.|.:..|.|....
Mouse   379 AMEVQLFFEL------ALGSFQGLVVAVLYCFLNGEVQLEVQKKWR-----QWHLQEFPLRPVAL 432

  Fly   603 SGAYNTA 609
            |.:::.|
Mouse   433 SNSFSNA 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	17/59 (29%)
		7tmB1_PDFR	306..584	CDD:320389	82/294 (28%)
		TM helix 1	308..333	CDD:320389	8/24 (33%)
		TM helix 2	342..364	CDD:320389	6/32 (19%)
		TM helix 3	391..418	CDD:320389	9/26 (35%)
		TM helix 4	430..450	CDD:320389	6/19 (32%)
		TM helix 5	469..498	CDD:320389	10/29 (34%)
		TM helix 6	512..539	CDD:320389	6/29 (21%)
		TM helix 7	546..571	CDD:320389	9/24 (38%)
Sctr	NP_001012322.2	HRM	77..140	CDD:397086	22/82 (27%)
		7tmB1_secretin	153..419	CDD:320403	82/302 (27%)
		TM helix 1	155..180	CDD:320403	8/24 (33%)
		TM helix 2	189..211	CDD:320403	6/21 (29%)
		TM helix 3	230..257	CDD:320403	9/26 (35%)
		TM helix 4	269..289	CDD:320403	7/20 (35%)
		TM helix 5	305..334	CDD:320403	10/28 (36%)
		TM helix 6	350..377	CDD:320403	5/26 (19%)
		TM helix 7	381..406	CDD:320403	10/30 (33%)