Protein Alignment Pdfr and mthl14

DIOPT Version :9

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_728509.1
• Gene: mthl14 / 318046
• FlyBaseID: FBgn0052476
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 99/607 - (16%)
• Similarity: 177/607 - (29%)
• Gaps: 251/607 - (41%)

  Fly   110 FESKSMLEPTSSHSLATGRVPLLHD----------FDA---STTESPGTY-----VLDGVARVAQ 156
            |.:.:.:...::.|..:....:.|:          .||   ||...|.||     .:.|......
  Fly    19 FNASAQISTVNNSSKGSNNSNIFHEDTFNSTSIDVLDASIHSTLVVPQTYSTEAATISGARFATS 83

  Fly   157 LALEPTVMDALPDSDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVN---YTLPQTGLYCNW 218
            :.::..|.:.|..:|..|       ...:.....:..::....|.....|   |...|:...|:
  Fly    84 VPVQSPVDNPLDPADCSQ-------REKYRKQPVATPSSRLRKCCPHGENLNIYRENQSDSMCD- 140

  Fly   219 TWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDY---G 280
              :.||.:.||....:...||             |...|::..               .||   .
  Fly   141 --NGLLSFEPTIISAVLFDNC-------------IEDLEVETT---------------LDYDIGN 175

  Fly   281 PCY-------KPEIIRLMQ--------QMGSKDF---DAY-IDIARR---------TRTLEIVGL 317
            ||.       |.::..::|        :.|::.:   :.| :||.:.         |:..|.:..
  Fly   176 PCNSSLLYDDKDDVFFVLQDGSLLIIDKFGNESYTVKEHYCLDIDKSGHLFAFTCVTQVEEQIAF 240

  Fly   318 CLSLFALIVSLL----------IFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNK 372
            ...:|..::.|:          :..|.|.|||    :|
  Fly   241 AKVVFVAVLMLISMPCLLLVSYLHMTLRLLRN----LH--------------------------- 274

  Fly   373 EAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTV----------AVFQGS 427
                ..|||::.    ||.||                  |.::|::|.:          .|.|..
  Fly   275 ----GLSLSLMS----LCLAS------------------GYFVHSVVHIYGIPNQGFIGYVIQFC 313

  Fly   428 FPLKFFSRLGWCVPILMTTVWAR--CTVMYMDTSLGEC--LW-NYNLTPY-YWILEGPRLAVIL- 485
            ....||..|..|..:|: .||.:  |.:        :|  .| .:|...| .:...||...|.|
  Fly   314 ILSYFFWYLCICFNVLL-NVWYKLPCCI--------QCSKSWATFNFACYAVFAFSGPATIVALT 369

  Fly   486 ----------------------------------LNFCFLVNIIRVLVMK--------------- 501
                                              |...||:|||.....:
  Fly   370 VQKGLPGMPSYFLQGLTESIRDSQRYFIPPVSTILFLSFLLNIISFFGFQRISGYAKAEKNIQER 434

  Fly   502 ---LRQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKT-----ATNFAVWSYGTHFLTSF 558
               ..|.:..|:::..|.|       .||||..::..|..:.|     .:|:.:.   ...:...
  Fly   435 KCLFDQQKYEDVKKDAKCV-------SLLGIIMVVSWLLEIITFYSGSNSNYLIL---CDMVNGL 489

  Fly   559 QGFFIALIYCFLNGEVRAVLLK 580
            ||.::.||:..:... |.::|:
  Fly   490 QGVWVLLIFLVVRRR-RTIILR 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	9/58 (16%)
		7tm_4	306..563	CDD:304433	57/349 (16%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	59/349 (17%)
		TM helix 1	241..266	CDD:320167	2/24 (8%)
		TM helix 2	275..297	CDD:320167	10/43 (23%)
		TM helix 3	306..331	CDD:320167	7/25 (28%)
		TM helix 4	349..369	CDD:320167	5/19 (26%)
		TM helix 5	389..418	CDD:320167	6/28 (21%)
		TM helix 6	445..472	CDD:320167	9/33 (27%)
		TM helix 7	477..502	CDD:320167	5/27 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462171
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930