DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdfr and Vipr2

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_058934.2	Gene:	Vipr2 / 29555	RGDID:	3962	Length:	437	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	103/376 - (27%)
Similarity:	170/376 - (45%)	Gaps:	54/376 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 CNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRK-CELDGRWGSRPNATEVNPPGWTDY 279
            |:..||.:.||.|...|....:.||..|....:|...|.| |..|| | |......::..|:.|
  Rat    51 CSGVWDNITCWRPADIGETVTVPCPKVFSNFYSRPGNISKNCTSDG-W-SETFPDFIDACGYND- 112

  Fly   280 GPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKI 344
                 ||        .......||.:    :.:..:|..:||.:|....:|.|.||.|...|..|
  Rat   113 -----PE--------DESKITFYILV----KAIYTLGYSVSLMSLTTGSIIICLFRKLHCTRNYI 160

  Fly   345 HKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVI--ENTP---YLCEASYVLLEYARTAM 404
            |.|||::.:|:.|..|.          |::...:|...:  .:.|   ..|:.|.|..:|...|.
  Rat   161 HLNLFLSFMLRAISVLV----------KDSVLYSSSGTLRCHDQPGSWVGCKLSLVFFQYCIMAN 215

  Fly   405 FMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYN- 468
            |.|:.:||||||.:: ||:...|.....:..:||.:|.:....|....:...||.   | |:.|
  Rat   216 FYWLLVEGLYLHTLL-VAILPPSRCFLAYLLIGWGIPSVCIGAWIATRLSLEDTG---C-WDTND 275

  Fly   469 -LTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQ--ASDIEQTRKAVRAAIVLLPLLGIT 530
             ..| :|::..|.|..|::||...::|:|:|:.||....  .:|..|.::..::.::|:||.|:.
  Rat   276 HSIP-WWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVH 339

  Fly   531 NLLHQLAPLKTATNFAVWSYGTHF---LTSFQGFFIALIYCFLNGEVRAVL 578
            .::....|:..::.:.:.     |   :.||||..:|::|||||.||:..|
  Rat   340 YMVFAAFPIGISSTYQIL-----FELCVGSFQGLVVAVLYCFLNSEVQCEL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	18/56 (32%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	70/268 (26%)
Vipr2	NP_058934.2	HormR	47..117	CDD:214468	22/81 (27%)
		7tmB1_VIP-R2	122..390	CDD:320652	81/289 (28%)
		TM helix 1	125..149	CDD:320652	5/27 (19%)
		TM helix 2	158..179	CDD:320652	8/30 (27%)
		TM helix 3	202..224	CDD:320652	7/21 (33%)
		TM helix 4	242..258	CDD:320652	3/15 (20%)
		TM helix 5	276..299	CDD:320652	7/23 (30%)
		TM helix 6	326..348	CDD:320652	4/21 (19%)
		TM helix 7	353..378	CDD:320652	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920