Protein Alignment Pdfr and GLP1R

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_002053.3
• Gene: GLP1R / 2740
• HGNCID: 4324
• Length: 463
• Species: Homo sapiens
• Alignment Length: 101
• Identity: 23/101 - (22%)
• Similarity: 42/101 - (41%)
• Gaps: 16/101 - (15%)

  Fly    18 LSIARASMMTPKASPKLAKYMEPVREEGQKKKKTRSMFSWLGGDSSKKKNKEVL---------ET 73
            |.:|.|:::   ..|.|...::..:::...||.|.:.|.....:|...:.|:.:         :.
Human    12 LGVASAAII---PEPTLDTEVQEQKDKEGLKKATWNEFVMKLNNSKNDQEKDGIDIELRVFFGQL 73

  Fly    74 VSEGLRKIYKQKLLPLEEFHKFHDFHSPALDDPDFD 109
            ..|.|.||......|:.|..|    ..|.:|||:|:
Human    74 TDEELMKIMTNIFHPMLEEEK----TQPVVDDPEFE 105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086
		7tmB1_PDFR	306..584	CDD:320389
		TM helix 1	308..333	CDD:320389
		TM helix 2	342..364	CDD:320389
		TM helix 3	391..418	CDD:320389
		TM helix 4	430..450	CDD:320389
		TM helix 5	469..498	CDD:320389
		TM helix 6	512..539	CDD:320389
		TM helix 7	546..571	CDD:320389
GLP1R	NP_002053.3	HRM	60..128	CDD:397086	12/50 (24%)
		7tmB1_GLP1R	141..419	CDD:341342
		TM helix 1	143..168	CDD:341342
		TM helix 2	177..199	CDD:341342
		TM helix 3	227..254	CDD:341342
		TM helix 4	266..286	CDD:341342
		TM helix 5	302..331	CDD:341342
		TM helix 6	345..372	CDD:341342
		Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:28514449	352..355
		TM helix 7	381..406	CDD:341342