Protein Alignment Pdfr and GIPR

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_011525011.1
• Gene: GIPR / 2696
• HGNCID: 4271
• Length: 508
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 114/430 - (26%)
• Similarity: 186/430 - (43%)
• Gaps: 104/430 - (24%)

  Fly   210 PQTGLYCNWTWDTLLCWPPTPAGVLARMNCPG--GFHGVDTRKFAIRKCELDGRWGSRPNATEVN 272
            |.:||.||.::|..:||........||.:||.  .:|......|.:|:|..||:||.
Human    55 PPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGL-------- 111

  Fly   273 PPGWTDYGPCYKPEIIRLMQQMGSKDFDAYID---IARRTRTLEIVGLCLSLFALIVSLLIFCTF 334
               |.|:..|..||          |: :|::|   |..|.:.:..||..|||..|:::|||...|
Human   112 ---WRDHTQCENPE----------KN-EAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLF 162

  Fly   335 RSLRNNRTKIHKNLFVAMVLQVIIRLTL---------YLDQFRRGNKEAAT-NTSLSVIENTPYL 389
            |.|...|..||.|||.:.:|:....|:.         ||     |::..|. |.:|:.
Human   163 RRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYL-----GDQALALWNQALAA------- 215

  Fly   390 CEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVM 454
            |..:.::.:|...|.:.|:.:||:|||:::.:.........:::..|||..|.|....|.....:
Human   216 CRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYL 280

  Fly   455 YMDTSLGECLWNYN-LTPYYWILEGPRLAVIL--------------------------------- 485
            |.:|   :| |..| :...:||:..|.|..||
Human   281 YENT---QC-WERNEVKAIWWIIRTPILMTILVGSVPPPPGRPQGFPILGSGLPPPPAPSEWDRG 341

  Fly   486 ---------LNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPL-- 539
                     :||...:.|:.:|:.|||..|....:...:..|:.:.|:||||:..::  .||:
Human   342 WLSPYLSPQINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVV--FAPVTE 404

  Fly   540 ---KTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRA 576
               :.|..||...:.. ||:|||||.::::|||:|.||::
Human   405 EQARGALRFAKLGFEI-FLSSFQGFLVSVLYCFINKEVQS 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	19/60 (32%)
		7tmB1_PDFR	306..584	CDD:320389	85/329 (26%)
		TM helix 1	308..333	CDD:320389	10/24 (42%)
		TM helix 2	342..364	CDD:320389	7/30 (23%)
		TM helix 3	391..418	CDD:320389	8/26 (31%)
		TM helix 4	430..450	CDD:320389	6/19 (32%)
		TM helix 5	469..498	CDD:320389	9/70 (13%)
		TM helix 6	512..539	CDD:320389	7/26 (27%)
		TM helix 7	546..571	CDD:320389	11/24 (46%)
GIPR	XP_011525011.1	HormR	57..126	CDD:214468	25/90 (28%)
		7tmB1_GlucagonR-like	134..451	CDD:341353	85/329 (26%)
		TM helix 1	136..161	CDD:341353	10/24 (42%)
		TM helix 2	170..192	CDD:341353	7/21 (33%)
		TM helix 3	217..244	CDD:341353	8/26 (31%)
		TM helix 4	256..276	CDD:341353	6/19 (32%)
		TM helix 5	292..363	CDD:341353	9/70 (13%)
		TM helix 6	377..404	CDD:341353	8/28 (29%)
		TM helix 7	413..438	CDD:341353	12/25 (48%)