Protein Alignment Pdfr and GHRHR

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_000814.2
• Gene: GHRHR / 2692
• HGNCID: 4266
• Length: 423
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 122/442 - (27%)
• Similarity: 195/442 - (44%)
• Gaps: 62/442 - (14%)

  Fly   163 VMDALPDSDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWP 227
            |:..||     .|||:::....:...|..      :..:.|.....:|.|.|.|..|||.|||||
Human    13 VLSPLP-----TVLGHMHPECDFITQLRE------DESACLQAAEEMPNTTLGCPATWDGLLCWP 66

  Fly   228 PTPAGVLARMNCPGGFHGVDTRKFAI-RKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLM 291
            ...:|....:.||..|....:...|: |.|.:.| |      :|..||    | |...|..:.|:
Human    67 TAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITG-W------SEPFPP----Y-PVACPVPLELL 119

  Fly   292 QQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQV 356
            .:.     ::|....:...|   ||..:|:.||.|::.|....|.|...|..:|..||...:|:.
Human   120 AEE-----ESYFSTVKIIYT---VGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKA 176

  Fly   357 IIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTV 421
               ..::|......:.:...:.|.|.:     ||:.|.....:|....|.|:..|.:||:.::..
Human   177 ---GAVFLKDAALFHSDDTDHCSFSTV-----LCKVSVAASHFATMTNFSWLLAEAVYLNCLLAS 233

  Fly   422 AVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLT-PYYWILEGPRLAVIL 485
            ..........:....||.:|:|.|..|..|.:.:.|.:   | |:.:.| ||:||::||.:..:.
Human   234 TSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIA---C-WDLDDTSPYWWIIKGPIVLSVG 294

  Fly   486 LNFCFLVNIIRVLVMKLRQSQASDIEQTR--KAVRAAIVLLPLLGITNLLHQLAPLKTATNFAV- 547
            :||...:||||:||.||..:|.|...|::  :..::.:.|:||.||..::....|........:
Human   295 VNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLP 359

  Fly   548 WSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGH---PEWAP 596
            ...|   |.|||||.:|::|||||.|||        |::|.:.|   ||..|
Human   360 LELG---LGSFQGFIVAILYCFLNQEVR--------TEISRKWHGHDPELLP 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	20/59 (34%)
		7tmB1_PDFR	306..584	CDD:320389	79/281 (28%)
		TM helix 1	308..333	CDD:320389	8/24 (33%)
		TM helix 2	342..364	CDD:320389	4/21 (19%)
		TM helix 3	391..418	CDD:320389	7/26 (27%)
		TM helix 4	430..450	CDD:320389	6/19 (32%)
		TM helix 5	469..498	CDD:320389	13/29 (45%)
		TM helix 6	512..539	CDD:320389	6/28 (21%)
		TM helix 7	546..571	CDD:320389	11/25 (44%)
GHRHR	NP_000814.2	HRM	52..112	CDD:397086	24/71 (34%)
		7tm_GPCRs	126..393	CDD:475119	81/292 (28%)
		TM helix 1	129..153	CDD:320398	8/26 (31%)
		TM helix 2	162..183	CDD:320398	5/23 (22%)
		TM helix 3	203..225	CDD:320398	5/21 (24%)
		TM helix 4	244..260	CDD:320398	5/15 (33%)
		TM helix 5	278..301	CDD:320398	9/22 (41%)
		TM helix 6	328..350	CDD:320398	5/21 (24%)
		TM helix 7	355..380	CDD:320398	11/27 (41%)