Protein Alignment Pdfr and mthl12

DIOPT Version :10

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 515
• Identity: 82/515 - (15%)
• Similarity: 176/515 - (34%)
• Gaps: 141/515 - (27%)

  Fly   104 APTAGTFESKSMLE----PTSSHSL-------------ATGRVPLLHDFDASTTESPGTYVLDGV 151
            |...|.|:.|.:::    ||...:|             ...|..:|.:.:.|          |||
  Fly    54 ANLTGEFDYKELMDGSKVPTEFPNLRGCICKVRPCIRICCARKNILSNGECS----------DGV 108

  Fly   152 ARVAQLA-LEPTVMDALPDSDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFV----NYTLPQ 211
            ....:|. |:.|:.|.|.   |:..|..||....:|.|........|:.|..:..    .||:.:
  Fly   109 KNEIKLTMLDLTMQDILL---TDPTLAELNMIPQYNSTELLILREQFQPCDEIVSLKRDEYTILK 170

  Fly   212 TGLYCNWTWDTLLCWPPTPAGVLAR-MNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPG 275
            .|       ..||   .|.|.:|:. ..|                               :.|..
  Fly   171 DG-------SILL---HTSAEILSNDQYC-------------------------------LYPEI 194

  Fly   276 WTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNN 340
            ::|:     ||.||::.:.      .|.::......|.::    |:...|::|.::.:...|||
  Fly   195 YSDF-----PETIRIINRR------CYRNVMPGIAQLSVI----SVVGFILTLAVYLSVEKLRN- 243

  Fly   341 RTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMF 405
              .:.|.|..::....:......:|.||             ::::   :|.|:..:..:...:.:
  Fly   244 --LLGKCLICSLFSMFMEYFIWTMDYFR-------------LLQS---ICSAAGYMKYFFSMSSY 290

  Fly   406 MWMFIEGLYLHNMVT-VAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLW---- 465
            :|..:...:|..:.| :...:..:....::...||...:.|.|......|: :...|:..|
  Fly   291 LWFSVVSFHLWELFTSLNRHEPQYRFLIYNTFVWCTAAIPTVVIFSMNQMW-ENDPGKSEWLPLV 354

  Fly   466 --------NYNLTPYYWILEGPRLAVILLNFCFLVNII--RVLVMKLRQSQASDIEQTRKAVRAA 520
                    ::|.:.:::    ..:.:::||...::..:  .:.:.|:::...|..:...:.....
  Fly   355 GYFGCSVKDWNSSSWFY----SHIPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCL 415

  Fly   521 ----------IVLLPLLGITNLLHQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFL 570
                      :.|..::|.:.||.||..|...::..:.:...:........|..||:..|
  Fly   416 EFNVQTYIQFVRLFLIMGASWLLDQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	7/59 (12%)
		7tmB1_PDFR	306..584	CDD:320389	40/290 (14%)
		TM helix 1	308..333	CDD:320389	4/24 (17%)
		TM helix 2	342..364	CDD:320389	2/21 (10%)
		TM helix 3	391..418	CDD:320389	3/26 (12%)
		TM helix 4	430..450	CDD:320389	4/19 (21%)
		TM helix 5	469..498	CDD:320389	2/30 (7%)
		TM helix 6	512..539	CDD:320389	6/36 (17%)
		TM helix 7	546..571	CDD:320389	4/25 (16%)
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053	41/219 (19%)
		7tmB3_Methuselah-like	220..488	CDD:410632	40/284 (14%)
		TM helix 2	246..268	CDD:410632	3/21 (14%)
		TM helix 3	276..303	CDD:410632	3/26 (12%)
		TM helix 4	316..336	CDD:410632	4/19 (21%)
		TM helix 5	364..394	CDD:410632	3/33 (9%)
		TM helix 6	410..444	CDD:410632	6/33 (18%)
		TM helix 7	449..479	CDD:410632	4/27 (15%)