DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and Ghrhr

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_017447971.1	Gene:	Ghrhr / 25321	RGDID:	2688	Length:	466	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	148/556 - (26%)
Similarity:	226/556 - (40%)	Gaps:	129/556 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GSSGPSPSAPTAGTFESKSMLEPTSSHSLATGRVPLLHDFDASTTESPGTYVLDGVARVAQLALE 160
            |..|......|.||....|:|       .||..:.||:              |.||| :..|.||
  Rat    12 GGKGHGSLGRTTGTTAMDSLL-------WATWVLCLLN--------------LWGVA-LGHLHLE 54

  Fly   161 PTVMDALPDSDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLC 225
            ...:..|.|.:.              ..|.:|..||              .:.:.|..|||.|||
  Rat    55 CDFITQLRDDEL--------------ACLQAAEGTN--------------NSSMGCPGTWDGLLC 91

  Fly   226 WPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNAT--EVNPPGWTDYGPCYK---P 285
            ||||.:|....:.||                |....:||.|.|.  :....||:|..|.|.   |
  Rat    92 WPPTGSGQWVSLPCP----------------EFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACP 140

  Fly   286 EIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFV 350
            ..:.|:.:  .|.:.:.:.|...|      |..:|:.||.|::.|....|.|...|..||..||.
  Rat   141 VPLELLTE--EKSYFSTVKIIYTT------GHSISIVALCVAIAILVALRRLHCPRNYIHTQLFA 197

  Fly   351 AMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYL 415
            ..:|:.   ..::|........::..:.|:|.|     ||:.|..:..:|....|.|:..|.:||
  Rat   198 TFILKA---SAVFLKDAAVFQGDSTDHCSMSTI-----LCKVSVAVSHFATMTNFSWLLAEAVYL 254

  Fly   416 HNMVTVAVFQGSFPLKFFSRL-GWCVPILMTTVWARCTVMYMDTSLGECLWNY-NLTPYYWILEG 478
             :.:..:....|.|..::..| ||.:|:|.|..|..|.:.:.||:   | |:. :.:||:||::|
  Rat   255 -SCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTA---C-WDLDDSSPYWWIIKG 314

  Fly   479 PRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTR----KAVRAAIVLLPLLGITNLLHQLAPL 539
            |.:..:.:||...:|||.:|:.||..:|..  ..||    :..::.::|:||.||..::.
  Rat   315 PIVLSVGVNFGLFLNIICILLRKLGPAQGG--LHTRAQYWRLSKSTLLLIPLFGIHYIIF----- 372

  Fly   540 KTATNFAVWSYGTHF-------LTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVR--GH-PEW 594
                ||...|.|...       |.|||||.:|::|||||.|||        |::|.:  || ||.
  Rat   373 ----NFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVR--------TEISRKWYGHDPEL 425

  Fly   595 APKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISP 630
            .|.|.:...  :.|.|.:....|...|......:.|
  Rat   426 LPARRTCTE--WTTPPRSRVKVPVYQPPTFSVPVCP 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	19/60 (32%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	74/269 (28%)
Ghrhr	XP_017447971.1	HRM	81..139	CDD:280888	24/73 (33%)
Ghrhr	XP_017447971.1	7tm_2	153..399	CDD:278432	75/275 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110