DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdfr and Fbxo46

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_780739.1	Gene:	Fbxo46 / 243867	MGIID:	2444918	Length:	603	Species:	Mus musculus

Alignment Length:	250	Identity:	55/250 - (22%)
Similarity:	76/250 - (30%)	Gaps:	90/250 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SNILDCGGCISAQRF---TRLLRQSGSSGPSPSAPTAGTFESKSMLEPTSSHSLATGRVPLLHDF 135
            |.:.:......|||.   |:.||:....||.|..... .|...::.||              |..
Mouse   225 SRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPGEVRI-AFRISNVREP--------------HSP 274

  Fly   136 DAST--------------TESPGTYVLDGVARVAQLALEPTVMDALPDSDTEQVLGNLNSSAPWN 186
            |.:.              :..|||...|.:.......:.|: .|||| |:.|.:|...:.
Mouse   275 DGNLPNGGGGRPGCAYPGSPGPGTRAKDKITCDLYQLISPS-RDALP-SNVEFLLARADE----- 332

  Fly   187 LTLASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFH------G 245
               ||...|...         |.|:         ||    ||.|....||.....|||      |
Mouse   333 ---ASEGETPAP---------TRPE---------DT----PPAPPPPPARDCGASGFHVDVVVTG 372

  Fly   246 VDTRKFAIRKCELDGRWGSR----------PNATEVNPPGWTDY----GPCYKPE 286
            |      :..|...|:.|::          .:..|..|||...:    ||...||
Mouse   373 V------VDACIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQSRGPEGPPE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	16/74 (22%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433
Fbxo46	NP_780739.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..165
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..301		17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..359		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..442		3/9 (33%)
		F-box-like	473..>507	CDD:372399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900