DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pdfr and ADGRE1

DIOPT Version :10

Sequence 1:NP_001245501.1 Gene:Pdfr / 31234 FlyBaseID:FBgn0260753 Length:738 Species:Drosophila melanogaster
Sequence 2:XP_011526096.1 Gene:ADGRE1 / 2015 HGNCID:3336 Length:978 Species:Homo sapiens


Alignment Length:332 Identity:82/332 - (24%)
Similarity:138/332 - (41%) Gaps:57/332 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 ATEVNPPGWTDYG-------------PCYKPEIIRLMQQMG--SKDFDAYIDIARRTRTLEIVGL 317
            :|:|....||.:|             .|.:...:.::...|  :.||..||        :..||:
Human   646 STDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGELTMDFSLYI--------ISHVGI 702

  Fly   318 CLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSV 382
            .:||..|::::..|...||:||:.|.:|.:|.|.::|    ..||:|....:.:.:..       
Human   703 IISLVCLVLAIATFLLCRSIRNHNTYLHLHLCVCLLL----AKTLFLAGIHKTDNKMG------- 756

  Fly   383 IENTPYLCEASYVLLEYARTAMFMWMFIEG----LYLHNMVTVAVFQG-SFPLKFFSRLGWCVPI 442
                   |......|.|...|.|.||.:|.    |.:.|:..|..|.. :..:......|:.:|:
Human   757 -------CAIIAGFLHYLFLACFFWMLVEAVILFLMVRNLKVVNYFSSRNIKMLHICAFGYGLPM 814

  Fly   443 LMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLR--QS 505
            |:..:.|  :|......:....|....|.:.|...||...||::|...|...:.:|..:|.  .:
Human   815 LVVVISA--SVQPQGYGMHNRCWLNTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLSSVNA 877

  Fly   506 QASDIEQTRKAVRAAIVLLPLLGITNLL--HQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYC 568
            :.|.::.||.....|...|.:||.:.:|  .|:.|:.     .|.:|....:.|.||.||.||:|
Human   878 EVSTLKDTRLLTFKAFAQLFILGCSWVLGIFQIGPVA-----GVMAYLFTIINSLQGAFIFLIHC 937

  Fly   569 FLNGEVR 575
            .|||:||
Human   938 LLNGQVR 944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PdfrNP_001245501.1 HRM 213..272 CDD:397086 1/3 (33%)
7tmB1_PDFR 306..584 CDD:320389 71/279 (25%)
TM helix 1 308..333 CDD:320389 6/24 (25%)
TM helix 2 342..364 CDD:320389 7/21 (33%)
TM helix 3 391..418 CDD:320389 8/30 (27%)
TM helix 4 430..450 CDD:320389 3/19 (16%)
TM helix 5 469..498 CDD:320389 8/28 (29%)
TM helix 6 512..539 CDD:320389 8/28 (29%)
TM helix 7 546..571 CDD:320389 10/24 (42%)
ADGRE1XP_011526096.1 TM helix 3 758..785 CDD:320555 7/26 (27%)
TM helix 4 802..822 CDD:320555 4/21 (19%)
TM helix 5 839..862 CDD:320555 7/22 (32%)
TM helix 6 886..911 CDD:320555 7/24 (29%)
TM helix 7 915..940 CDD:320555 10/24 (42%)
EGF_CA 33..62 CDD:238011
EGF_CA 80..114 CDD:214542
EGF_CA 132..171 CDD:214542
EGF_CA 172..206 CDD:214542
EGF_CA 224..260 CDD:214542
EGF_CA 264..297 CDD:214542
EGF_CA 313..>342 CDD:214542
EGF_CA 360..393 CDD:214542
GPS 638..687 CDD:197639 6/40 (15%)
7tmB2_EMR 691..953 CDD:320555 75/287 (26%)
TM helix 1 693..718 CDD:320555 8/32 (25%)
TM helix 2 727..749 CDD:320555 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

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