Protein Alignment Pdfr and Glp1r

DIOPT Version :9

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_067307.2
• Gene: Glp1r / 14652
• MGIID: 99571
• Length: 463
• Species: Mus musculus
• Alignment Length: 441
• Identity: 115/441 - (26%)
• Similarity: 183/441 - (41%)
• Gaps: 74/441 - (16%)

  Fly   200 CSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDT--RKFAIRKCELDGRW 262
            |........|..|||:||.|:|...|||..|.|....::||.......:  :....|.|..:|.|
Mouse    46 CQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLW 110

  Fly   263 GSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDF------DAYIDIARRTRTLEIVGLCLSL 321
            ..:.|::    ..|.|...|.:       .:.|.::|      ..||        :..||..||.
Mouse   111 LHKDNSS----LPWRDLSECEE-------SKRGERNFPEEQLLSLYI--------IYTVGYALSF 156

  Fly   322 FALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENT 386
            .||:::..|...||.|...|..||.|||.:.:|:.   |::::       |:||.....|.....
Mouse   157 SALVIASAILVGFRHLHCTRNYIHLNLFASFILRA---LSVFI-------KDAALKWMYSTAAQQ 211

  Fly   387 PYL-----------CEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCV 440
            ...           |...::|::|...|.:.|:.:||:||:.::..:||......|.:..:||.|
Mouse   212 HQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGV 276

  Fly   441 PILMTTVWARCTVMYMDTSLGECLWNYNLTPYYW-ILEGPRLAVILLNFCFLVNIIRVLVMKLRQ 504
            |:|....|.....:|.|    |..|..|....|| |:..|.|..|.:||...:.:|.::|.||:.
Mouse   277 PLLFVIPWGIVKYLYED----EGCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKA 337

  Fly   505 SQASDIEQTRKAVRAAIVLLPLLGITNLL-------HQLAPLKTATNFAVWSYGTHFLTSFQGFF 562
            :.....:...:..::.:.|:||||...::       |....|:....|...|:     |||||..
Mouse   338 NLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSF-----TSFQGLM 397

  Fly   563 IALIYCFLNGEVRAVL--------LKSLATQLSVRGHPEWAPKRASMYSGA 605
            :|::|||:|.||:...        |:.|..|......|...| .:|:.|||
Mouse   398 VAILYCFVNNEVQMEFRKCWERWRLEHLNIQRDCSMKPLKCP-TSSVSSGA 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	18/60 (30%)
		7tm_4	306..563	CDD:304433	71/275 (26%)
Glp1r	NP_067307.2	HRM	59..128	CDD:280888	21/72 (29%)
		7tm_2	141..398	CDD:278432	73/283 (26%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250|UniProtKB:P43220	352..355		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920