Protein Alignment Pdfr and Gcgr

DIOPT Version :9

• Sequence 1: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: XP_017169752.1
• Gene: Gcgr / 14527
• MGIID: 99572
• Length: 497
• Species: Mus musculus
• Alignment Length: 510
• Identity: 130/510 - (25%)
• Similarity: 219/510 - (42%)
• Gaps: 97/510 - (19%)

  Fly   163 VMDALPDSDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVNYTL--PQTGLYCNWTWDTLLC 225
            |:..||::.:.||:..|...  |.|        ..:.|..   |.:|  |.||.:  |:    |.
Mouse    17 VLSCLPEAPSAQVMDFLFEK--WKL--------YSDQCHH---NLSLLPPPTGDF--WS----LL 62

  Fly   226 WPP--------------TPAGV------LARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATE 270
            .||              ||||:      |.....||.:.|....:...::|..||:|...|....
Mouse    63 HPPAPSQSWSVTEPSTSTPAGLTPLPTPLPTFPAPGTYLGTTKHRLVFKRCGPDGQWVRGPRGQP 127

  Fly   271 VNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEI---VGLCLSLFALIVSLLIFC 332
                 |.:...|          |:..::.:....:|:...:.::   ||..|||.||:::|:|..
Mouse   128 -----WRNASQC----------QLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILL 177

  Fly   333 TFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQF--RRGNKEAATNTSLSV--IENTPYLCEAS 393
            ..|.|...|..||.|||.:.||:.  ...|.:|..  .|.:::...:.|:||  .:.....|..:
Mouse   178 GLRKLHCTRNYIHGNLFASFVLKA--GSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVA 240

  Fly   394 YVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDT 458
            .|:::|...|.:.|:.:||:||::::::|.|........:..:||..|:|....|.....::.:.
Mouse   241 TVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENV 305

  Fly   459 SLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVL 523
               :|..:.:...::|||..|....:|:||...|:||.:||.|||..|....:...:..|:.:.|
Mouse   306 ---QCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTL 367

  Fly   524 LPLLGITNLL-------HQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLL-- 579
            :||||:..::       |....|::...|.     ..||:||||..:|::|||||.||:|.|:
Mouse   368 IPLLGVHEVVFAFVTDEHAQGTLRSTKLFF-----DLFLSSFQGLLVAVLYCFLNKEVQAELMRR 427

  Fly   580 -------KSLATQLSVRGH-PEWAPKRASMYSGAYNTAP-DTDAVQPAGDPSATG 625
                   |:|..:.....| ...||      :|..:..| :...:..||..|.||
Mouse   428 WRQWQEGKALQEERLASSHGSHMAP------AGPCHGDPCEKLQLMSAGSSSGTG 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	18/78 (23%)
		7tm_4	306..563	CDD:304433	74/270 (27%)
Gcgr	XP_017169752.1	7tmB1_GCGR	149..429	CDD:320395	83/289 (29%)
		TM helix 1	154..178	CDD:320395	9/23 (39%)
		TM helix 2	187..208	CDD:320395	8/22 (36%)
		TM helix 3	238..260	CDD:320395	5/21 (24%)
		TM helix 4	279..295	CDD:320395	4/15 (27%)
		TM helix 5	313..336	CDD:320395	7/22 (32%)
		TM helix 6	358..383	CDD:320395	6/24 (25%)
		TM helix 7	392..417	CDD:320395	11/29 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920