DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and Calcr

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001363947.1	Gene:	Calcr / 12311	MGIID:	101950	Length:	533	Species:	Mus musculus

Alignment Length:	503	Identity:	151/503 - (30%)
Similarity:	235/503 - (46%)	Gaps:	90/503 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 GLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWT 277
            |||||.|||..:||..||||..|..:||..|...||.:...:.|:.:|.|...|::...    |:
Mouse    86 GLYCNRTWDGWMCWDDTPAGATAYQHCPDYFPDFDTAEKVSKYCDENGEWFRHPDSNRT----WS 146

  Fly   278 DYGPC--YKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNN 340
            :|..|  :..|.::          :||:     ...|.:||..||:.||:.|:|||..|::|...
Mouse   147 NYTLCNAFTSEKLQ----------NAYV-----LYYLALVGHSLSIAALVASMLIFWIFKNLSCQ 196

  Fly   341 RTKIHKNLFVAMVLQVIIRLTLYL-------DQFRRG--------------NKEAATNTSLSVIE 384
            |..:||::|:..:|..|| :.::|       |..||.              ..|.:....||..|
Mouse   197 RVTLHKHMFLTYILNSII-IIIHLVEVVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLSAHE 260

  Fly   385 N--TPYL-----CEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPI 442
            .  .|:.     |:..:.|.:|..:..:.||..||:|||.::.:|||.....|:::..|||..||
Mouse   261 GKMDPHASEVISCKVLHFLHQYMMSCNYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPI 325

  Fly   443 LMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQA 507
            :.|.:.|....:|.:.:   | |....|...:|:.||.:..:::||.||:||:||||.|:||:..
Mouse   326 VPTIIHAITRALYYNDN---C-WLSAETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMRQTHE 386

  Fly   508 SDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNG 572
            ::.....|||:|.:||:|||||..::....|...... .::.|..|.|..|||||:|.||||.|.
Mouse   387 AESYMYLKAVKATMVLVPLLGIQFVVFPWRPSNKVLG-KIYDYLMHSLIHFQGFFVATIYCFCNH 450

  Fly   573 EVRAVLLKSLATQLSVRGHPEWAPKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPNKRLNG 637
            ||: |.||...||..::....|..:|                 :|      |.:.:|.| :.:..
Mouse   451 EVQ-VTLKRQWTQFKIQWSQRWGRRR-----------------RP------TNRVVSAP-RAVAF 490

  Fly   638 RKPSSASIVMIH-EPQQRQRLMPRLQNKAREKGKD----RVEKTDAEA 680
            .:|....|.:.| ||:.     |.:.|...|:..:    .|.:.||.|
Mouse   491 AEPDGLPIYICHQEPRN-----PPISNNEGEESTEMIPMNVIQQDASA 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	24/58 (41%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	89/284 (31%)
Calcr	NP_001363947.1	HRM	86..154	CDD:367186	27/71 (38%)
		7tmB1_calcitonin_R	162..472	CDD:341343	105/321 (33%)
		TM helix 1	164..189	CDD:341343	11/29 (38%)
		TM helix 2	198..220	CDD:341343	6/22 (27%)
		TM helix 3	274..301	CDD:341343	9/26 (35%)
		TM helix 4	313..333	CDD:341343	7/19 (37%)
		TM helix 5	348..377	CDD:341343	11/28 (39%)
		TM helix 6	391..418	CDD:341343	11/26 (42%)
		TM helix 7	424..449	CDD:341343	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6141
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.790