DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdfr and ADCYAP1R1

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001186564.1	Gene:	ADCYAP1R1 / 117	HGNCID:	242	Length:	496	Species:	Homo sapiens

Alignment Length:	445	Identity:	114/445 - (25%)
Similarity:	190/445 - (42%)	Gaps:	105/445 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 CNWTWDTLLCWPPTPAGVLARMNCP----------------------GGFHGVDTRKFAI--RKC 256
            |...||.:.||.|...|.:..::||                      |..:.:|.....:  |.|
Human    54 CPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNC 118

  Fly   257 ELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSL 321
            ..|| | |.|.....:..|:.:|           ..:.|.:|: .|:.:    :.|..||...||
Human   119 TEDG-W-SEPFPHYFDACGFDEY-----------ESETGDQDY-YYLSV----KALYTVGYSTSL 165

  Fly   322 FALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENT 386
            ..|..:::|.|.||.|...|..||.||||:.:|:.|   ::::..:....::.:.:..:|.:|
Human   166 VTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAI---SVFIKDWILYAEQDSNHCFISTVE-- 225

  Fly   387 PYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARC 451
               |:|..|...|...:.:.|:|||||||..::....|.......:::.:||..|.:..||||..
Human   226 ---CKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATL 287

  Fly   452 TVMYMDTSLGECLWNYN-LTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKL------------- 502
            .:.:.||.   | |:.| .|..:|:::||.:..|::||...:.||.:||.||
Human   288 RLYFDDTG---C-WDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIY 348

  Fly   503 -------------------RQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTA-TNFAV 547
                               :.|:.|.|  |.:..|:.::|:||.||...:...:|...: ....|
Human   349 FSCVQKCYCKPQRAQQHSCKMSELSTI--TLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLV 411

  Fly   548 WSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMY 602
            :..|   |.|||||.:|::||||||||:|.:.:            :|...:.:.|
Human   412 FELG---LGSFQGFVVAVLYCFLNGEVQAEIKR------------KWRSWKVNRY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	18/79 (23%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	79/290 (27%)
ADCYAP1R1	NP_001186564.1	HRM	52..137	CDD:308439	19/84 (23%)
		7tmB1_PACAP-R1	150..445	CDD:320653	91/327 (28%)
		TM helix 1	152..177	CDD:320653	7/28 (25%)
		TM helix 2	186..208	CDD:320653	8/24 (33%)
		TM helix 3	227..254	CDD:320653	11/26 (42%)
		TM helix 4	266..286	CDD:320653	6/19 (32%)
		TM helix 5	302..331	CDD:320653	9/28 (32%)
		TM helix 6	347..402	CDD:320653	10/56 (18%)
		TM helix 7	407..432	CDD:320653	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920