DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdfr and CALCRL

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_005246289.2	Gene:	CALCRL / 10203	HGNCID:	16709	Length:	472	Species:	Homo sapiens

Alignment Length:	455	Identity:	135/455 - (29%)
Similarity:	210/455 - (46%)	Gaps:	85/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 GLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWT 277
            |:|||.|||..|||....||..:...||..|...|..:...:.|:.||.|...|.:...    ||
Human    73 GVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT----WT 133

  Fly   278 DYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRT------LEIVGLCLSLFALIVSLLIFCTFRS 336
            :|..|                   .::...:.:|      |.|:|..||:.:|::||.||..|:|
Human   134 NYTQC-------------------NVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKS 179

  Fly   337 LRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYAR 401
            |...|..:|||||.:.|...::.: ::|..........|||         |..|:.|..:..|..
Human   180 LSCQRITLHKNLFFSFVCNSVVTI-IHLTAVANNQALVATN---------PVSCKVSQFIHLYLM 234

  Fly   402 TAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWN 466
            ...:.||..||:|||.::.||||.....|.::..|||..|::...:.|....:|.:.:   | |.
Human   235 GCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDN---C-WI 295

  Fly   467 YNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITN 531
            .:.|...:|:.||..|.:|:|..||:||:|||:.||:.:..::.....|||||.::|:|||||..
Human   296 SSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF 360

  Fly   532 LLHQLAPLKTATNFA--VWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEW 594
            :   |.|.:.....|  |:.|..|.|..|||..::.|:||.||||:|:|.::            |
Human   361 V---LIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRN------------W 410

  Fly   595 APKRASMYSGAY-NTAPDTDAVQPAGDPSATGKRISP--------PNKRLNGRKPSSASIVMIHE 650
                 :.|...: |:..:::|::.|   |.|...||.        |::.|||:.        ||:
Human   411 -----NQYKIQFGNSFSNSEALRSA---SYTVSTISDGPGYSHDCPSEHLNGKS--------IHD 459

Fly 651 650
Human 460 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	21/58 (36%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	86/264 (33%)
CALCRL	XP_005246289.2	HRM	73..141	CDD:397086	25/90 (28%)
		7tmB1_calcitonin_R	149..422	CDD:341343	97/306 (32%)
		TM helix 1	152..176	CDD:341343	10/23 (43%)
		TM helix 2	185..206	CDD:341343	6/21 (29%)
		TM helix 3	224..246	CDD:341343	5/21 (24%)
		TM helix 4	265..281	CDD:341343	4/15 (27%)
		TM helix 5	298..321	CDD:341343	8/22 (36%)
		TM helix 6	346..368	CDD:341343	11/24 (46%)
		TM helix 7	374..399	CDD:341343	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840