DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdfr and glp2r

DIOPT Version :9

Sequence 1:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_009304634.1	Gene:	glp2r / 101885514	-ID:	-	Length:	517	Species:	Danio rerio

Alignment Length:	513	Identity:	145/513 - (28%)
Similarity:	222/513 - (43%)	Gaps:	115/513 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 TEQVLGNLNSSAPWNL-----TLASAAATN---------FENCSALFVNYTLPQ-TGLYCNWTWD 221
            ||..:|...||||..|     |..|.:..:         .|||:. |:..|||. ||.:||.|:|
Zfish     3 TELQMGRRRSSAPLLLLFLCCTPVSGSVLDDLIYKRSEYQENCTR-FLTATLPAGTGTFCNGTFD 66

  Fly   222 TLLCWPPTPAGVLARMNCP--------GGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTD 278
            ...|||.:..||:: :.||        |....|      .::|.::|.|.:..|::.|    |.:
Zfish    67 VFACWPHSSPGVVS-VPCPPYLPWIREGATGNV------YKECTVNGTWKTEENSSSV----WRN 120

  Fly   279 YGPCYKPEIIRLMQQMGSKDFDAYIDIARRT--RTLEIVGLCLSLFALIVSLLIFCTFRSLRNNR 341
            ...|......:..::          ::.|::  |.|.|||..||..:|.:::||....|.|...|
Zfish   121 QSECENHYFFKSEEE----------EVFRQSVLRVLSIVGYSLSFSSLCLAVLIMSLLRKLHCTR 175

  Fly   342 TKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTP---------------YLCE 391
            ..||.||||:.:.:.|..:|          ||.....:.|   |.|               ::|:
Zfish   176 NYIHINLFVSFMFRAIAVIT----------KEVILQVAYS---NLPRDEVGWNSYTKSAISFICK 227

  Fly   392 ASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYM 456
            ||.|.|||.....:.|:.:|.::||.::..||......||.:..:||..|:|....|.....:|.
Zfish   228 ASKVSLEYFVGCNYFWLLVEAVFLHTLLFTAVLTRKTLLKKYIFIGWGTPLLFVIPWTVAKTLYE 292

  Fly   457 DTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAI 521
            :.|   | |..|:...:||:.||....:::.||..:.|||:|:.||:..|....:......||.:
Zfish   293 NKS---C-WMNNIRWIWWIIRGPITLSVIVIFCIFLKIIRLLLSKLKADQVKFTDYRYSLARATL 353

  Fly   522 VLLPLLGITNLLHQL-------APLKTATNFAVWSYGTHF-LTSFQGFFIALIYCFLNGEVRAVL 578
            ||:||||:..::..|       ...:.|.||      .|. |:||||..:|::|||.||||:|.|
Zfish   354 VLIPLLGVHQIVFTLIIDESVEGSNRYARNF------VHLTLSSFQGLIVAVLYCFANGEVQAEL 412

  Fly   579 LKSLATQLSVRG------------HPE--W-----APKRASMYSGAYNTAPDTDAVQP 617
            .|  ..||.|..            ||:  |     :|:....::.. |...|.|..||
Zfish   413 KK--RWQLLVSSSSFEVHSCFSDIHPKHLWKFSQKSPRPHPQHTDT-NEEGDQDTSQP 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	18/66 (27%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433	83/281 (30%)
glp2r	XP_009304634.1	HRM	58..127	CDD:280888	21/79 (27%)
glp2r	XP_009304634.1	7tm_2	142..397	CDD:278432	82/277 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010